Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study)

Hartmann, Katrin; Liese, Johannes G.; Kemmling, Daniel; Prifert, Christiane; Weißbrich, Benedikt; Thilakarathne, Pushpike; Diels, Joris; Weber, Karin; Streng, Andrea

doi:10.1093/infdis/jiac137

Cited by 23 publications

(27 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the recently published INSPIRE Study, for the period 2015-2018, RSV was shown to increase the burden of hospitalized children (≤ 5 years) in Germany, particularly among preterm infants and those < 6 months old [11]. In contrast to our CLRS, however, the authors analyzed not only intensive care unit (ICU) admissions, but also hospital length of stay on general wards and ICUs, supplemental oxygen demand and medication usage.…”

Section: Discussionmentioning

confidence: 99%

High burden of RSV hospitalizations in Germany 2021–2022

et al. 2022

View full text Add to dashboard Cite

Background Public health measures implemented to mitigate the effects of the COVID-19 pandemic disrupted the worldwide transmission of endemic respiratory viruses such as RSV, as well as other typical, seasonal, and viral respiratory pathogens. Methods From October 18, 2021 to March 31, 2022, RSV cases admitted to German pediatric hospitals were monitored via a newly established, national, Clinician-Led Reporting System (CLRS) that recorded patient age and type of respiratory support. A subanalysis of the first 4 months of the monitoring period was additionally performed. ResultsIn October 2021, a total of 471 hospitalized pediatric RSV cases per day were documented by 67 reporting hospitals. By January 2022, this number dropped to three cases at 11 hospitals (median of reporting hospitals: 37 (11%)). During these months, the median of hospitalized children on general wards and intensive care units was 133 and 15, respectively. In the subanalysis conducted to examine the period October to January, an average of 3.6 ± 2.2 patients per hospital per day were hospitalized on general wards (median 4 cases; range 0.3-8 cases), whereas 0.4 ± 2.2 patients were on intensive care units (median 0.3 cases; range 0-0.9 cases), with 11.5% receiving respiratory support. The majority of patients were under 2 years old. ConclusionThe overall burden of out-of-season RSV cases was extraordinarily high in Germany in 2021-2022. The newly established CLRS may help evaluate and, therefore, better allocate local and national pediatric care resources.

show abstract

Section: Discussionmentioning

confidence: 99%

High burden of RSV hospitalizations in Germany 2021–2022

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In a third study that used data from laboratory testing, hospital admissions, and syndromic surveillance in England, Bardsley et al (2022) reported that the burden of laboratory-confirmed RSV cases shifted from children of <1 year pre-COVID-19 to 1-4 years in summer of 2021 (17). In general, results from this and other research in different settings, countries, and time periods (6,7,9,(23)(24)(25)(26) have demonstrated that the highest hospitalization burden levels are commonly observed among children <1 years of age. The COVID-19 impact on shifts in hospitalization burden among children requires further study.…”

Section: Discussionmentioning

confidence: 78%

“…Additionally, routinely collected data on healthcare outcomes, such as length of stay, have the potential to be used to inform healthcare prevention strategies. For example, Hartmann et al (2022) found that pneumonia, oxygen need, and preterm birth were predictors for prolonged hospital stays (25).…”

Section: Discussionmentioning

confidence: 99%

Quantifying changes in respiratory syncytial virus—associated hospitalizations among children in Texas during COVID-19 pandemic using records from 2006 to 2021

Uwak

Johnson²,

Mustapha³

et al. 2023

Front. Pediatr.

View full text Add to dashboard Cite

AimTo quantify changes on RSV- associated hospitalizations during COVID-19 pandemic, among children four years of age or younger at the state and county levels of Texas using routinely acquired hospital admission records.MethodsWe used the Texas Public Use Data Files (PUDF) of the Department of State Human Services (DSHS) to obtain hospital admissions and healthcare outcomes from 2006 to 2021. We used the 2006–2019 period to estimate a long-term temporal trend and predict expected values for 2020–2021. Actual and predicted values were used to quantify changes in seasonal trends of the number of hospital admissions and mean length of hospital stay. Additionally, we calculated hospitalization rates and assessed their similarity to rates reported in the RSV Hospitalization Surveillance Network (RSV-NET).ResultsAn unusually low number of hospitalizations in 2020 was followed by an unusual peak in the third quarter of 2021. Hospital admissions in 2021 were approximately twice those in a typical year. The mean length of hospital stay typically followed a seasonal trend before COVID-19, but increased by a factor of ∼6.5 during the pandemic. Spatial distribution of hospitalization rates revealed localized healthcare infrastructure overburdens during COVID-19. RSV associated hospitalization rates were, on average, two times higher than those of RSV-NET.ConclusionHospital admission data can be used to estimate long-term temporal and spatial trends and quantify changes during events that exacerbate healthcare systems, such as pandemics. Using the mean difference between hospital rates calculated with hospital admissions and hospital rates obtained from RSV-NET, we speculate that state-level hospitalization rates for 2022 could be at least twice those observed in the two previous years, and the highest in the last 17 years.

show abstract

“…Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) in young children worldwide, 1–3 with bronchiolitis being the most common clinical manifestation of RSV‐related LRTI in infants 4–9 . Compared with influenza, RSV causes up to 16 times more hospital stays and emergency room visits in children younger than 5 years 1 .…”

Section: Introductionmentioning

confidence: 99%

“…A study in seven European countries showed that children born 2 months before the peak of the RSV season were more likely to be hospitalized due to RSV in the first year of life 16 . Compared with term infants, preterm infants are at increased risk for RSV‐related LRTI and a severe course of RSV disease, including higher RSV hospitalization and intensive care unit (ICU) admission rates and longer hospital length of stay (LOS) 5,17–19 . In addition to prematurity, chronic conditions, such as congenital heart disease (CHD), are associated with a more severe course of RSV infection 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Inpatient burden of respiratory syncytial virus in children ≤2 years of age in Germany: A retrospective analysis of nationwide hospitalization data, 2019–2022

Wick,

Poshtiban,

Kramer

et al. 2023

Influenza Resp Viruses

View full text Add to dashboard Cite

BackgroundRespiratory syncytial virus (RSV) causes respiratory tract disease in seasonal waves, primarily in infants and young children. This study aims to quantify the number of RSV‐related hospitalizations in children ≤2 years of age and to determine corresponding resource use and costs in Germany.MethodsWe retrospectively analyzed population‐wide hospital data from the Institute for the Hospital Remuneration System (InEK) from 2019 to 2022. RSV cases were identified using the RSV‐specific 10th revision of the International Classification of Diseases (ICD‐10) codes J12.1, J20.5, and J21.0. The RSV‐associated proportion of all hospitalizations caused by severe acute respiratory infections (SARIs), clinical manifestations, length of stay (LOS), intensive care unit (ICU) admissions, ventilation rates, and hospitalization costs were retrieved.ResultsWe identified 98,220 hospitalizations (26,052, 15,407, 31,362, and 25,399 in 2019, 2020, 2021, and 2022, respectively) with a principal RSV diagnosis in children aged ≤2 years in Germany. The majority of RSV hospitalizations (73,178) occurred in infants (<1 year), with annual incidence rates ranging from 14.9 to 28.6 per 1000 population. Fifty‐eight percent of all SARI hospitalizations in this age group were attributable to RSV. In children aged ≤2 years, mean LOS was 4.5 days, 6.1% of cases were admitted to ICU, and 5.3% of cases were ventilated. Mean hospitalization costs per case ranged from €3001 to €3961 over the study period.ConclusionsRSV causes substantial disease burden and is a leading cause of SARI‐related hospital admissions of children ≤2 years of age in Germany. Our results confirm the need to explore and evaluate strategies to prevent RSV in infants and young children.

show abstract

Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study)

Cited by 23 publications

References 44 publications

High burden of RSV hospitalizations in Germany 2021–2022

High burden of RSV hospitalizations in Germany 2021–2022

Quantifying changes in respiratory syncytial virus—associated hospitalizations among children in Texas during COVID-19 pandemic using records from 2006 to 2021

Inpatient burden of respiratory syncytial virus in children ≤2 years of age in Germany: A retrospective analysis of nationwide hospitalization data, 2019–2022

Contact Info

Product

Resources

About