Clinical cardiomyoplasty: Review of the ten-year United States experience

Magovern, George J.; Simpson, Kathleen A.

doi:10.1016/0003-4975(95)01005-x

Cited by 83 publications

(34 citation statements)

References 12 publications

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“…In analogy, we have used in this study two-dimensional electrophoresis, mass spectrometry and immunoblotting to determine the differential expression of the fast skeletal muscle proteome following chronic lowfrequency stimulation. Our findings might further our understanding of the molecular and cellular effects of fibre conditioning, and therefore may help in the improved design of stimulation protocols used in biomedical applications such as dynamic cardiomyoplasty [3,4]. In contrast to studying individual proteins by conventional biochemical techniques, the proteomics method allows a more comprehensive survey of a great variety of different muscle protein species using one experimental approach.…”

Section: Introductionmentioning

confidence: 99%

“…Chronic low-frequency stimulation of fast-twitch skeletal muscles is an experimental technique that has been extensively used to enhance our basic understanding of the physiological properties of transforming muscle fibres [1,2] and to develop improved biomedical treatments that exploit muscle plasticity [3,4]. The detailed analysis of fibre transition processes on the molecular and cellular level has established skeletal muscles as a class of tissue that can quickly adapt to changed functional demands [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation

Donoghue

Doran

Dowling

et al. 2005

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Physiological and biochemical responses of skeletal muscle fibres to enhanced neuromuscular activity under conditions of maximum activation can be studied experimentally by chronic low-frequency stimulation of fast muscles. Stimulation-induced changes in the expression pattern of the rabbit fast skeletal muscle proteome were evaluated by two-dimensional gel electrophoresis and compared to the altered isoform expression profile of established transformation markers such as the Ca 2+ -ATPase, calsequestrin and the myosin heavy chain. Sixteen muscle proteins exhibited a marked change in their expression level. This included albumin with a 4-fold increase in abundance. In contrast, glycolytic enzymes, such as enolase and aldolase, showed a decreased expression. Concomitant changes were observed with marker elements of the contractile apparatus. While the fast isoforms of troponin T and myosin light chain 2 were drastically down-regulated, their slow counterparts exhibited increased expression. Interestingly, mitochondrial creatine kinase expression increased while the cytosolic isoform of this key muscle enzyme decreased. The expression of the small heat shock protein HSP-B5/aB-crystallin and the oxygen carrier protein myoglobin were both increased 2-fold following stimulation. The observed changes indicate that the conversion into fatigue-resistant red fibres depends on: (i) the optimum utilization of free fatty acids via albumin transportation, (ii) a rearrangement of the creatine kinase isozyme pattern for enhanced mitochondrial activity, (iii) an increased availability of oxygen for aerobic metabolism via myoglobin transport, (iv) the conversion of the contractile apparatus to isoforms with slower twitch characteristics and (v) the up-regulation of chaperone-like proteins for stabilising myofibrillar components during the fast-to-slow transition process. D

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation

Donoghue

Doran

Dowling

et al. 2005

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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“…The LDM was then trained by increasing electrical stimulation by a myocardial burst stimulator to condition the previously fatigable, type II, skeletal muscle fiber into a nonfatigable, type I, contractile tissue. A review of the 10-year experience in the USA reported over a decade ago (1996) demonstrated a significant increase in LV ejection fraction (25 vs 30%) and LV Stroke Work Index (LVSWI; 26.1 vs 34.3 g/m/beat) after 6 months [13]. Although DC did not translate into a measurable survival benefit when studied in patients with end stage heart disease, this concept has inspired several investigators to look at similar methods of structural support or physiologic augmentation that are still under investigation.…”

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confidence: 99%

Surgical management of congestive heart failure: translational research to clinical application – the future is bright!

Chedrawy

Prasad

Massad

2008

Expert Review of Cardiovascular Therapy

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“…As limitações dos programas de TX, dificultando-os na maioria das vezes em caráter de urgência, envidam que sejam procuradas alternativas para o TX (2) ou ainda pontes para transplante, incluindo pontes farmacológicas, apesar das limitações (3) , dispositivos mecânicos de assistência cardiocirculatória (4,5) , cardiomioplastia (6,7) , valvuloplastia mitral (8) e ventriculectomia parcial Frota Filho J D, Lucchese F A, Blacher C, Leães P E, Halperin C, Lúcio E A, Pereira W, Sales M, Lunkenheimer P P, Redmann K, Vargas L E, Stuermer R, Lobo R, Moreira F, Bueno A P, Jung L A -Ventriculectomia parcial esquerda: ponte para transplante? Rev Bras Cir Cardiovasc 2000; 15 (4): 320-7.…”

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Ventriculectomia parcial esquerda: ponte para transplante?

Filho¹,

Lucchese²,

Blacher³

et al. 2000

Rev Bras Cir Cardiovasc

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(1) . As limitações dos programas de TX, dificultando-os na maioria das vezes em caráter de urgência, envidam que sejam procuradas alternativas para o TX (2) ou ainda pontes para transplante, incluindo pontes farmacológicas, apesar das limitações (3) , dispositivos mecânicos de assistência cardiocirculatória (4,5) , cardiomioplastia (6,7) , valvuloplastia mitral (8) e ventriculectomia parcial Frota Filho J D, Lucchese F A, Blacher C, Leães P E, Halperin C, Lúcio E A, Pereira W, Sales M, Lunkenheimer P P, Redmann K, Vargas L E, Stuermer R, Lobo R, Moreira F, Bueno A P, Jung L A -Ventriculectomia parcial esquerda: ponte para transplante? Rev Bras Cir Cardiovasc 2000; 15 (4): 320-7. RESUMO: Objetivo: Analisar os resultados e a viabilidade da ventriculectomia parcial esquerda (VPE) como ponte para transplante cardíaco (TX).Delineamento: Estudo de coorte histórica e prospectivo. Casuística e Métodos: Cinquenta e três pacientes (pts) foram submetidos a VPE em um período de 5 anos. Destes, 7 pts com contra-indicação inicial ao TX, idades variando de 37 a 64 anos, 5 homens e 2 mulheres, com miocardiopatia dilatada, foram subseqüentemente relistados e transplantados. Foram analisados a fração de ejeção (FE), o diâmetro diastólico final do ventrículo esquerdo (DDFVE), a CF da NYHA, o consumo máximo de oxigênio (VO 2 máx) e os escores de qualidade de vida (QV) antes da VPE, aos 3 e 6 meses, e pré-transplante.Resultados: Os valores expressos a seguir referem-se, respectivamente, àqueles obtidos antes da VPE, aos 3 e 6 meses e antes do TX. Variação da CF da NYHA: 3,71±0,49, 2,57±1,13 (p=0,011), 3,0±1,29 e 3, 86±0,38. Evolução da FE: 25,17±6,15, 35,5±8,41 (p=0,013), 32,33±7,12 e 26,17±3,76. Variação do DDFVE: 79,16±10,85, 67,66±9,2, 65,83±9,57 e 64,25±8,99. O VO 2 máx era de 8,12±3,47 antes da VPE e de 13,2±7,75 aos 6 meses (p=0,068). Variação dos escores de QV: 4,29±1,25, 3,0±1,41 (p=0,050), 3,29±1,8 e 4,57±1,13. Foram transplantados 7/53 pts (13,20%). A sobrevida, até a data do transplante, variou de 7 a 37 meses (18,71±11,78 meses). O seguimento foi de 100%.Conclusão: A curto prazo melhoraram a CF da NYHA, a QV, o VO 2 máx, o DDFVE e a FE dos pts. Estes resultados sugerem a possibilidade da indicação da VPE como ponte para TX. Entretanto, a mortalidade elevada no primeiro semestre pós-operatório limita a sua indicação rotineira como ponte para TX. Estudos futuros poderão validar ou não esta possibilidade.

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Clinical cardiomyoplasty: Review of the ten-year United States experience

Cited by 83 publications

References 12 publications

Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation

Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation

Surgical management of congestive heart failure: translational research to clinical application – the future is bright!

Ventriculectomia parcial esquerda: ponte para transplante?

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