Clinical Case of Palmoplantar Keratoderma Type Unna-Thost

Pashinyan, A G; Гургеновна, Пашинян Альбина; Ilyenko, L.I.; И, Ильенко Л.; Akopyan, A. N; Н, Акопян А.

doi:10.18821/1560-9588-2017-20-3-143-145

Russ. J. Skin & Ven. Dis.

2017

DOI: 10.18821/1560-9588-2017-20-3-143-145

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Clinical Case of Palmoplantar Keratoderma Type Unna-Thost

A G Pashinyan

Пашинян Альбина Гургеновна²,

L.I. Ilyenko

et al.

Abstract: Palmar-plantar keratoderma is a heterogeneous group of hereditary dermatosis, which can be independent diseases or combined with various congenital malformations, most of ectodermal origin. Approaches to differential diagnosis and clinical features of each form of this pathology are described. Keratoderma, Unna Toast genodermatosis belongs to the group, which is characterized by hyperkeratosis on the palms and soles without migration to other skin areas.

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Cited by 3 publications

References 14 publications

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Detoxifying Ability of Peat Humic Acids to Petroleum Products in the Soil Ecosystem

Dmitrieva¹,

Gertsen²,

Dremova³

2022

JCPRM

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The stimulating effect of humic acids on the growth of the biomass of the test object was established. А series of positive effects on the biomass of seedlings was proposed. The correlation dependence of the effect of toxicants on the cockweed on its composition was revealed. It was shown that the light ends of oil has a minimal toxic effect on cockweed due to increased volatility, in contrast to petroleum. The detoxifying ability of peat humic acids was established separately and together with oil-degrading microorganisms of the genus Rhodococcus on the inert substrate by the method of biotesting. Humic acids had a stimulating effect on the test object regardless of their genesis. The maximum stimulating effect on the test object was exhibited by humic acids isolated from fen peats. The biomass of cockweed seedlings on contaminated soil in the presence of humic acids and microorganisms of the genus Rhodococcus in all variants of experiments with model toxicants was higher compared to the variant without treatment with humic acids. The detoxification coefficients of humic acids were calculated separately and together with oil-degrading microorganisms of the genus Rhodococcus in the relation to hexadecane: the humic acids of sphagnum high-moor peat and sphagnum transitional peat showed the maximum detoxifying effect: 70−75%. Combined use of humic acids and microorganisms Rh. erythropolis S67, Rh. erythropolis X5 increased the detoxifying effect of humic acids by 4−22%. The values of the detoxification coefficients vary in the range of 59−85%, depending on the genesis of humic acids and the selected strain of microorganisms. The values of the detoxification coefficients of humic acids together with moil-degrading microorganisms of the genus Rhodococcus exceed the indicators of control and experimental options using only humic acids due to the ability of Rhodococcus to produce biologically active surfactants capable of more emulsification and biodegradation of oil hydrocarbons in the environment.

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Detoxifying Ability of Peat Humic Acids to Petroleum Products in the Soil Ecosystem

Dmitrieva¹,

Gertsen²,

Dremova³

2022

JCPRM

View full text Add to dashboard Cite

show abstract

Hereditary keratoderma. Clinical case: Unna–Toast keratoderma and Buschke–Fischer–Brauer keratoderma

Grabovskaya

Teplyuk

Kolesova

et al. 2022

Russian Journal of Skin and Venereal Diseases

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Palmoplantar keratoderma is a heterogeneous group of diseases, both hereditary and acquired, affecting, as a rule, the skin of the palms and soles in the form of focal or diffuse hyperkeratotic layers. Hereditary forms are characterized by a defect in the genes encoding certain structural components of keratinocytes, which leads to the corresponding clinical manifestations. The actual method of genomic sequencing has made it possible to identify the localization of defects in certain genes for specific types of hereditary palmoplantar keratoderma, however, despite the big step in diagnosis, therapy still remains complex and can only reduce the manifestations of the disease and improve the quality of life, and not cure it completely. The authors demonstrate a clinical case of UnnaToast keratoderma in a young patient with a long history of treatment of the disease, who showed a pronounced positive dynamics from the skin process against the background of the use of local agents, as well as the use of such a physiotherapeutic method as local PUVA therapy. In addition, the article provides a clinical case of hereditary keratoderma BuschkeFischerBrauer as an example of an accidentally diagnosed disease at a dermatologists appointment.

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Hereditary keratoderma of Unna-Tost in a patient with atopic dermatitis

Teplyuk,

Tavitova,

Pishulina

et al. 2023

Russian Journal of Skin and Venereal Diseases

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Unna-Toast's keratoderma is a disease belonging to the group of genodermatoses with an autosomal dominant type of inheritance and characterized by hyperkeratosis on the palms and soles. This nosology can manifest itself at any age as an independent process, but more often it debuts at 12 years of age, in some cases combined with various congenital malformations of ectodermal origin. The prevalence of this disease ranks second among hereditary dyskeratoses, however, it is rare in the practice of a dermatologist and there are no static data on the disease. The article presents a clinical observation of Unna-Toast's keratoderma that first appeared against the background of atopic dermatitis. The clinical picture is represented by smooth yellow horny layers located on the palms and soles, with a sharply defined border and an erythematous corolla along the periphery. Other areas of the skin are represented by lichenification foci with small-lamellar peeling, excoriations and serous-hemorrhagic crusts on the surface. This clinical case confirms the possibility of manifestation of hereditary hyperkeratosis against the background of aggressive atopic dermatitis. Unna-Tost's keratoderma is of high interest in the practice of a dermatologist and requires a detailed description of the available clinical cases, due to the rare occurrence of this nosology in the population.

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Clinical Case of Palmoplantar Keratoderma Type Unna-Thost

Cited by 3 publications

References 14 publications

Detoxifying Ability of Peat Humic Acids to Petroleum Products in the Soil Ecosystem

Detoxifying Ability of Peat Humic Acids to Petroleum Products in the Soil Ecosystem

Hereditary keratoderma. Clinical case: Unna–Toast keratoderma and Buschke–Fischer–Brauer keratoderma

Hereditary keratoderma of Unna-Tost in a patient with atopic dermatitis

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