Clinical Cerenkov Luminescence Imaging of<sup>18</sup>F-FDG

Thorek, Daniel L.J.; Riedl, Christopher C.; Grimm, Jan

doi:10.2967/jnumed.113.127266

Cited by 157 publications

(153 citation statements)

References 15 publications

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“…Like other optical imaging techniques, tissue penetrating limitation and low sensitivity for deep targets are the intrinsic limitations of CLI 25,32 . 39,40 . Compared to PET imaging, CLI can be performed with a relatively low cost imaging system.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to PET imaging, CLI can be performed with a relatively low cost imaging system. Recently, Thorek et al demonstrated that significantly high sensitivity could be achieved with CLI as low amounts of 18 F-FDG accumulated (about 2Ci) in the nodes of patients 39,40 . In vitro testing indicated that CLI signal from 0.01 Ci 90Y was detectable in solution 25,32,33 .…”

Section: Discussionmentioning

confidence: 99%

“…3D tomography of CLI has been intensively studied in several groups 28,[34][35][36][37] , and the applications of CLI for endoscopic imaging and intraoperative imaging have been successfully demonstrated in mice as well 30,38 . In addition, Spinelli and Thorek et al have demonstrated that CLI imaging could be applied to human subjects, thus the technology also has potential for clinical applications 39,40 .…”

Section: Introductionmentioning

confidence: 99%

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Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Zhang

Kuo

Moore

et al. 2014

JoVE

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Brown adipose tissue (BAT), widely known as a "good fat" plays pivotal roles for thermogenesis in mammals. This special tissue is closely related to metabolism and energy expenditure, and its dysfunction is one important contributor for obesity and diabetes. Contrary to previous belief, recent PET/CT imaging studies indicated the BAT depots are still present in human adults. PET imaging clearly shows that BAT has considerably high uptake of 18 F-FDG under certain conditions. In this video report, we demonstrate that Cerenkov luminescence imaging (CLI) with 18 F-FDG can be used to optically image BAT in small animals. BAT activation is observed after intraperitoneal injection of norepinephrine (NE) and cold treatment, and depression of BAT is induced by long anesthesia. Using multiple-filter Cerenkov luminescence imaging, spectral unmixing and 3D imaging reconstruction are demonstrated. Our results suggest that CLI with 18 F-FDG is a practical technique for imaging BAT in small animals, and this technique can be used as a cheap, fast, and alternative imaging tool for BAT research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Zhang

Kuo

Moore

et al. 2014

JoVE

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“…The CL of isotopes traditionally used for PET imaging is poor, and the re-use of established PET tracers for CLI is therefore limited. Although frequencies produced in pure CL are heavily attenuated, limiting penetration depth and sensitivity 79,[81][82][83] , it is possible to shift the effective frequency of CLI-probe emission toward the NIR through the incorporation of fluorophores into CLI probes. Herein, characteristic ultraviolet-blue CR is absorbed by a fluorophore and re-emitted at lower NIR-visible frequencies, enhancing tissue penetration and facilitating detection, and therefore increasing the utility of CL in the clinic.…”

Section: Pet/spect-oimentioning

confidence: 99%

Multiplexed imaging for diagnosis and therapy

et al. 2017

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Complex molecular and metabolic phenotypes depict cancers as a constellation of different diseases with common themes. Precision imaging of such phenotypes requires flexible and tuneable modalities capable of identifying phenotypic fingerprints by using a restricted number of parameters whilst ensuring sensitivity to dynamic biological regulation. Common phenotypes can be detected by in vivo imaging technologies, and effectively define the emerging standards for disease classification and patient stratification in radiology. However, for the imaging data to accurately represent a complex fingerprint, the individual imaging parameters need to be measured and analysed in relation to their wider spatial and molecular context. In this respect, targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment, and lead to the expansion of rational-design elements for the combination of imaging experiments. In this Review, we evaluate criteria for conducting multiplexed imaging, and discuss its opportunities for improving patient diagnosis and the monitoring of therapy.

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“…Since Cerenkov imaging uses light emission caused by β-particles travelling through a medium, detection of these signals seems to be the most straightforward technique to include an optical imaging readout in a nuclear medicine setting. This technique can be applied to known PET tracers such as 18 F-FDG [6]. While the low photon flux (amount of emitted light) and the unfavourable wavelength (the peak of the emitted light lies in the wavelength area with maximal tissue absorbance, <400 nm) are major limiting factors, the technique has nevertheless already been successfully applied in both preclinical and clinical settings.…”

Section: Optical Imaging As An Add-on To Nuclear Imagingmentioning

confidence: 99%