Clinical challenges of SARS‑CoV‑2 variants (Review)

Cojocaru, Cristian; Cojocaru, Elena; Turcanu, Adina; Zaharia, Dragoş

doi:10.3892/etm.2022.11343

Cited by 19 publications

(25 citation statements)

References 67 publications

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“…The importance of applying molecular screens is that they can detect the presence of virus or its remnants [5] at any stage of the disease, because these screens have been shown to detect high, medium and low viral loads, unlike serological tests because performance is influenced by symptomatology, days of infection, or virus lineage and they are not confirmatory tests for the disease [13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

Comparación de dos métodos isotérmicos para la detección de SARS-COV-2 en Callao, Perú

et al. 2023

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Objetivo: Comparar las técnicas de cribado molecular isotérmico CPA y RT-LAMP, frente a la prueba de referencia, la reacción en cadena de la polimerasa cuantitativa de transcripción inversa (RT-qPCR), y determinar su concordancia. Materiales y métodos: Estudio comparativo de casos y controles emparejados. Para la evaluación del método CPA se utilizaron 70 casos y 130 controles, mientras que para la RT-LAMP se utilizaron 30 casos y 70 controles. Se calcularon la sensibilidad y la especificidad de ambas pruebas. Posteriormente, se calculó el índice Kappa corregido por sesgo mediante un nuevo muestreo. Resultados: Ambas técnicas presentan valores adecuados y equivalentes de sensibilidad (RT-LAMP: 82,8 %, CPA: 83 %) y especificidad (RT-LAMP y CPA: 91,5 %), así como una alta concordancia (88 %), y un índice Kappa (0,72). Conclusiones: Ambas técnicas de cribado molecular isotérmico son adecuadas para el cribado del SARS-CoV-2, con una sensibilidad y especificidad similares.

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Section: Discussionmentioning

confidence: 99%

Comparación de dos métodos isotérmicos para la detección de SARS-COV-2 en Callao, Perú

et al. 2023

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“…Different SARS‑CoV‑2 variants linked with increased transmissibility and immune evasion have altered the clinical presentation and hospitalization rate of acute coronavirus disease 2019 (COVID‐19) 2 …”

Section: Introductionmentioning

confidence: 99%

“…Different SARS-CoV-2 variants linked with increased transmissibility and immune evasion have altered the clinical presentation and hospitalization rate of acute coronavirus disease 2019 (COVID-19). 2 Fever, a dry cough, and exhaustion were typical symptoms of COVID-19 in children, while seizures were a rare sign in COVID-19 patients. 3 A few studies have described seizures in children with the Omicron variant.…”

mentioning

confidence: 98%

The diversity in the clinical features of children hospitalized with COVID‐19 during the nonvariant, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variant periods of SARS CoV‐2: Caution for neurological symptoms in Omicron variant

Şahin

Karadağ‐Öncel

Buyuksen

et al. 2023

Journal of Medical Virology

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Since the COVID-19 pandemic began, various severe acute respiratory syndrome coronavirus 2 variants have been identified with different characteristics than the nonvariant strain. We retrospectively evaluated the demographic and clinical differences in the cohort of hospitalized COVID-19 children (1 month-18 years old) between March 11, 2020, and September 31, 2022, by the time the variants identified in our country predominate. Bonferroni post hoc analysis was performed to compare the differences between the periods. Of the 283 children in this study, 142 (50.2%) were females. The median age was 36 (interquartile range [IQR]: 7-132) months. Sixty-three (22.2%) patients were hospitalized in the nonvariant period, 24 (8.5%) in the Alpha period, 93 (32.9%) in the Delta period, and 103 (36.4%) in the Omicron period. Fever was the most common symptom in all groups, with no statistically significant differences (p = 0.25). In the Omicron period, respiratory and gastrointestinal symptoms decreased, and neurological symptoms increased significantly compared to other periods: [respiratory symptoms; nonvariant (65.1%) vs. Omicron (41.7%), (p = 0.024)], [gastrointestinal symptoms; Delta (41.9%) vs. Omicron (22.3%), (p = 0.018), [neurological symptoms; Delta (14.5%) vs. Omicron (31.1%), (p = 0.03]. Altered mental status and seizures were more common during the Omicron period compared to the pre-Omicron (nonvariant, Alpha, and Delta) period (p = 0.017 and p = 0.005, respectively). Although the main symptoms in children with COVID-19 were fever and respiratory symptoms, an increase in severe neurological manifestations was seen throughout the Omicron variant period.

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“…Currently, the Omicron variant has become the most dominant SARS‐CoV‐2 strain disseminating globally. This variant contains >60 substitutions, deletions and insertions mutations, including 39 on S protein, of which 15 occur in the receptor‐binding domain (RBD) which confer a considerable increase in morbidity 23,24 . Multiple Omicron mutations reported to be identical in the Alpha and Delta variants resulted in increasing transmissibility rate of +105% compared with Delta variant 25 .…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants

Ali

Rashid

Ali

et al. 2023

Eur J Clin Investigation

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BackgroundThe pandemic of coronavirus disease 2019 (COVID‐19) has a broad spectrum of clinical manifestations. The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) undergoes continuous evolution, resulting in the emergence of several variants. Each variant has a different severity and mortality rate.Materials and MethodsIn this study, 1174 COVID‐19 patients were studied for mortality and severity over three SARS‐CoV‐2 predominating variant periods in 2021 and 2022 in Sulaimani Province, Iraq. In each period, a representative, variant virus was subjected to phylogenetic and molecular and clinical analysis.ResultsPhylogenetic analysis revealed three SARS‐CoV‐2 variants, belonging to: Delta B.1.617.2, Omicron BA.1.17.2, and Omicron BA.5.6. The Delta variants showed more severe symptoms and a lower PCR‐Ct value than Omicron variants regardless of gender, and only 4.3% of the cases were asymptomatic. The mortality rate was lower with Omicron (.5% for BA.5.2 and 1.3% for BA.1.17.2) compared with Delta variants (2.5%). The higher mortality rate with Delta variants was in males (2.84%), while that with Omicron BA1.17.2 and BA.5.2 was in females, 1.05% and .0%, respectively. Age group (≥70) years had the highest mortality rate; however, it was (.0%) in the age group (30–49) years with Omicron variants, compared with (.96%) in Delta variants.ConclusionsThere has been a surge in COVID‐19 infection in the city due to the predominant lineages of SARS‐CoV‐2, B.1.617, Omicron BA.1.17.2 and Omicron BA.5.6, respectively. A higher PCR‐Ct value and severity of the Delta variant over Omicron BA.1.17.2 and/or BA.5.2 variants were significantly correlated with a higher death rate in the same order.

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Clinical challenges of SARS‑CoV‑2 variants (Review)

Cited by 19 publications

References 67 publications

Comparación de dos métodos isotérmicos para la detección de SARS-COV-2 en Callao, Perú

Comparación de dos métodos isotérmicos para la detección de SARS-COV-2 en Callao, Perú

The diversity in the clinical features of children hospitalized with COVID‐19 during the nonvariant, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variant periods of SARS CoV‐2: Caution for neurological symptoms in Omicron variant

Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants

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