Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicine

Endo, Ryoma; Sugimoto, Seiichiro; Shirosaki, Koji; Kato, Hirochika; Wada, Mitsuru; Kanai, Takanori; Sato, Toshiro

doi:10.1016/j.reth.2023.06.001

Cited by 2 publications

(2 citation statements)

References 121 publications

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“…In 2021, Sato et al found that transplanting ileal organoids into the colon of SBS rats can generate Small intestinalized colon (SIC) [111]. SIC can perform small intestine functions, reshape lymphatic vessel structures, and maintain muscular tissue regulated by nerve circuits and autonomous nervous control [38].…”

Section: The Status and Challenges Of Intestinal Organoids Transplant...mentioning

confidence: 99%

“…Currently, intestinal organoids are widely used in fields such as Crohn's disease, colorectal cancer (CRC) disease modeling, drug screening, microbiota studies, and biomolecular delivery [35][36][37]. Additionally, in recent years, the development of regenerative medicine based on organoids as a new treatment for ulcerative colitis (UC) and short bowel syndrome (SBS) has become a focal point of interest [38][39][40].…”

Section: Introductionmentioning

confidence: 99%

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Current applications of intestinal organoids: a review

Xiang,

Wang,

2024

Stem Cell Res Ther

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In the past decade, intestinal organoid technology has paved the way for reproducing tissue or organ morphogenesis during intestinal physiological processes in vitro and studying the pathogenesis of various intestinal diseases. Intestinal organoids are favored in drug screening due to their ability for high-throughput in vitro cultivation and their closer resemblance to patient genetic characteristics. Furthermore, as disease models, intestinal organoids find wide applications in screening diagnostic markers, identifying therapeutic targets, and exploring epigenetic mechanisms of diseases. Additionally, as a transplantable cellular system, organoids have played a significant role in the reconstruction of damaged epithelium in conditions such as ulcerative colitis and short bowel syndrome, as well as in intestinal material exchange and metabolic function restoration. The rise of interdisciplinary approaches, including organoid-on-chip technology, genome editing techniques, and microfluidics, has greatly accelerated the development of organoids. In this review, VOSviewer software is used to visualize hot co-cited journal and keywords trends of intestinal organoid firstly. Subsequently, we have summarized the current applications of intestinal organoid technology in disease modeling, drug screening, and regenerative medicine. This will deepen our understanding of intestinal organoids and further explore the physiological mechanisms of the intestine and drug development for intestinal diseases.

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Section: The Status and Challenges Of Intestinal Organoids Transplant...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current applications of intestinal organoids: a review

Xiang,

Wang,

2024

Stem Cell Res Ther

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Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering

Hu,

Zhu,

Cui

et al. 2024

Adv Healthcare Materials

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Organoids, with their capacity to mimic the structures and functions of human organs, have gained significant attention for simulating human pathophysiology and have been extensively investigated in the recent past. Additionally, 3D bioprinting, as an emerging bio‐additive manufacturing technology, offers the potential for constructing heterogeneous cellular microenvironments, thereby promoting advancements in organoid research. In this review, the latest developments in 3D bioprinting technologies aimed at enhancing organoid engineering are introduced. The commonly used bioprinting methods and materials for organoids, with a particular emphasis on the potential advantages of combining 3D bioprinting with organoids are summarized. These advantages include achieving high cell concentrations to form large cellular aggregates, precise deposition of building blocks to create organoids with complex structures and functions, and automation and high throughput to ensure reproducibility and standardization in organoid culture. Furthermore, this review provides an overview of relevant studies from recent years and discusses the current limitations and prospects for future development.

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Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicine

Cited by 2 publications

References 121 publications

Current applications of intestinal organoids: a review

Current applications of intestinal organoids: a review

Integrating 3D Bioprinting and Organoids to Better Recapitulate the Complexity of Cellular Microenvironments for Tissue Engineering

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