Clinical characteristics and coronary angiographic findings of patients with unstable angina, acute myocardial infarction, and survivors of sudden ischemic death occurring during and after sport

Ciampricotti, Renzo; Gamal, Mamdouh El; Relik, Theodorus H. F. M.; Taverne, Rob; Panis, Jan; Swart, Johannes de; Gelder, Berry van; Wely, Lucia Relik-van

doi:10.1016/0002-8703(90)90235-p

Cited by 37 publications

(15 citation statements)

References 65 publications

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“…Because thrombosis is responsible for many exertionrelated ischemic events (Giri et al 1999), the persistent increase in vWf:Ag may contribute to exertion-related events that occur following exercise (Ciampricotti et al 1990;Mittleman et al 1993). Currently, the American College of Sports Medicine recommends an AC to enhance venous return and prevent decreased cerebral and cardiac blood flow (Franklin et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, there is a hemostatic imbalance in the post-exercise period that may positively influence clot formation. Occlusive thrombi are more prevalent in exertion-related events (Giri et al 1999) and exertion triggers ischemic events during and after physical activity (Ciampricotti et al 1990;Mittleman et al 1993); therefore, decreasing potential for coagulation following exercise may have important clinical significance.…”

Section: Introductionmentioning

confidence: 99%

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Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down

et al. 2004

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The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake (VO2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen (vWf:Ag), tissue plasminogen activator (tPA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using repeated measures analysis of variance. No significant differences were found between VO2max tests for treadmill time, VO2max, respiratory exchange ratio, maximal heart rate, or maximal blood lactate concentration. vWf:Ag was significantly elevated (P <0.05)following PC [198.4 (18.3)% normal] versus AC [174.5 (15.6)% normal] and remained elevated 1-h post-exercise [179.4 (16.4)% normal for PC vs 158.6 (13.8)% normal for AC]. There were no differences between tests for tPA or PAI-1 activity, although tPA antigen was significantly elevated following PC versus AC (P <0.05). Following the cool-down, hematocrit was higher (P <0.05) for the PC test [48.90 (0.36)] compared with AC [47.43 (0.51)]. An AC reduces post-exercise vWf:Ag and tPA antigen without affecting tPA or PAI-1 activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down

et al. 2004

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“…Giri et al reported that patients with an exertion-related MI were more likely to have risk factors including male sex, hyperlipidemia, hypertension and current cigarette smoking (59 % versus 37 % in non exertion-related MI) but in a population of which had known coronary artery disease and older than that of our study (Giri et al 1999). There were 28 cigarette smokers in a population of 42 patients in one study on unstable angina, SMI and SSD related to sport (Ciampricotti et al, 1990). We find in our study, with a small number of patients, few risk factors in this population but often family history of coronary disease and 4/12 patients without risk factor.…”

Section: Which Athletes and Which Sports?mentioning

confidence: 46%

Peculiarities of Coronary Artery Disease in Athletes

Xavier¹,

Akoudad²,

Ouceyni³

et al. 2012

Recent Advances in Cardiovascular Risk Factors

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“…The observations by Airaksinen et al . and the greater increase in dispersion of repolarization during PTCA to the left anterior descending artery in this study might be of clinical relevance for the development of sustained arrhythmias, since there seems to be a preponderance of atherosclerosis of the left anterior descending artery in young victims of sudden death [33, 34].…”

Section: Discussionmentioning

confidence: 99%

Changes in ventricular repolarization during percutaneous transluminal coronary angioplasty in humans assessed by QT interval, QT dispersion and T vector loop morphology

Nowinski

Jensen²,

Lundahl

et al. 2000

Journal of Internal Medicine

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Abstract. Nowinski K, Jensen S, Lundahl G, Bergfeldt L (Karolinska Hospital, Stockholm, Norrlands University Hospital, Umea Ê and Ortivus AB, Ta Èby, Sweden). Changes in ventricular repolarization during percutaneous transluminal coronary angioplasty in humans assessed by QT interval, QT dispersion and T vector loop morphology. J Intern Med 2000; 248: 126±136.Objectives. Based on clinical, epidemiological, and experimental data, transient cardiac ischaemia is one of the major triggering factors of malignant ventricular arrhythmia. According to animal studies, increased dispersion of repolarization is of pathophysiological relevance in this context. Therefore we explored the impact of myocardial ischaemia during single vessel coronary angioplasty on the change in ventricular repolarization, measured by QT and JT intervals and their dispersion in the 12-lead electrocardiogram. We also assessed a novel method, the 3-dimensional T vector loop, to find out whether it was sensitive to changes in ventricular repolarization during ischaemia, and whether there was any correlation with changes in the dispersion of the QT and/or JT intervals. Design. This study was prospective with consecutive patients. Only patients in sinus rhythm and without bundle branch block were included. Setting. All coronary angioplasties were performed at Norrlands University Hospital, Umea Ê. The analysis of the material was performed at the Karolinska Hospital, Stockholm. Subjects. Twenty-nine consecutive patients went through 30 elective one-vessel percutaneous transluminal coronary angioplasty (PTCA) procedures. PTCA was performed in 10 stenoses of the left anterior descending, 10 of the left circumflex, and 10 of the right coronary artery. Interventions. A 12-lead electrocardiogram was recorded continuously as part of routine monitoring of the patient during PTCA and the T vector loop was calculated from the simultaneously recorded. X, Y, Z leads. Main outcome measures. Repolarization was assessed by the QRS, QT and JT intervals as well as by the T vector loop parameters (Tarea, Tavplan, and Teigenv) before and at the end of the first occlusion during PTCA. Results. PTCA, with an average occlusion time of 171 6 60 s (mean 6 SD), induced ischaemia on the 12-lead electrocardiogram in 73% of cases. The overall response for the 30 procedures was a significantly increased dispersion of ventricular repolarization, both corrected and uncorrected for heart rate. QT dispersion increased by, on average, 19% from 74 6 35 to 88 6 36 ms, QT c dispersion by 27% from 71 6 39 to 90 6 42 ms, and JTc dispersion by 19% from 78 6 32 to 94 6 43 ms (P , 0.05). The T vector loop became more circular and bulgy during occlusion (all three parameters changed by between 33% and 59%). There was a significant correlation between changes in one of the T vector loop parameters (Teigenv), and changes in JT and QT dispersion in the left anterior descending group. Conclusions. Transient ischaemia during PTCA induced significant changes in ventricular repolarization, especial...

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Clinical characteristics and coronary angiographic findings of patients with unstable angina, acute myocardial infarction, and survivors of sudden ischemic death occurring during and after sport

Cited by 37 publications

References 65 publications

Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down

Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down

Peculiarities of Coronary Artery Disease in Athletes

Changes in ventricular repolarization during percutaneous transluminal coronary angioplasty in humans assessed by QT interval, QT dispersion and T vector loop morphology

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