Clinical Characteristics and Factors Associated with Poor Outcomes in Hospitalized Patients with Novel Coronavirus Infection COVID-19

Boytsov, S. А.; Палеев, Ф. Н.; Ezhov, M.; Комаров, А. Л.; Pevsner, D V; Gruzdev, K A; Barinova, I V; Suvorov, А. Yu.; Алексеева, И. А.

doi:10.18087/cardio.2021.2.n1532

Cited by 25 publications

(10 citation statements)

References 18 publications

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“…Повышенный уровень тропонинов у больных с COVID-19, свидетельствующий об остром повреждении миокарда, был связан с более тяжелым течением заболевания и повышением смертности от вирусного заболевания в 4 раза [12]. В российский популяции больных с COVID-19 высокочувствительный тропонин Т (вчTnT) >25,7 мг / л также был предиктором неблагоприятного исхода [13]. Метаанализ 4-х исследований у 341 пациента с COVID-19 показал различия показателей вчTnI у тяжелых пациентов по сравнению со средне-лёгкими [14].…”

Section: биомаркеры имеющие доказательную базуunclassified

“…К кардиальным биомаркерам прежде всего относится вчTnI/T. В ретроспективных исследованиях и метаанализах было показано, что концентрации вчTn, NT-proBNP и КФК МВ были значительно выше у пациентов с тяжелыми формами COVID-19 [12,13,43]. Ввиду наличия достаточной доказательной базы данных, очевидно, что на сегодняшний день вчTnI является оптимальным биомаркером миокардиального повреждения по сравнению с КФК-MB, миоглобином и NT-proBNP вследствие его высокой чувствительности при оценке динамики состояния и повреждения миокарда.…”

Section: растворимая изоформа -Sst2unclassified

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Serum biomarkers of cardiovascular complications in COVID-19

et al. 2021

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The coronavirus disease 2019 (COVID-19) affects not only the respiratory system, but also the cardiovascular system in 20-28% of cases, causing endothelial dysfunction, vasculitis, hyper- and hypocoagulation, myocarditis, endothelial dysfunction and other adverse effects. The presence of cardiovascular risk factors and diseases has been shown to worsen the disease severity and increase mortality from COVID-19. Recent studies have also found that elevations in some serum cardiovascular biomarkers can stratify the disease severity, in particular rates of hospitalizations to an internal medicine or intensive care unit, intubation, and mortality. They can be divided into markers of damage (TnT/I, creatine phosphokinase (CPK) and CPK-MB, myoglobin, NT-proBNP), coagulation (prothrombin time, fibrinogen and D-dimer), as well as prospective biomarkers for which the available evidence base is limited but there is a pathophysiological rationale (homocysteine and sST2). This review presents studies on the use of above serum biomarkers to stratify the risk of death in patients with COVID-19.

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Section: биомаркеры имеющие доказательную базуunclassified

Section: растворимая изоформа -Sst2unclassified

Serum biomarkers of cardiovascular complications in COVID-19

et al. 2021

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“…Patients in the other group (TICU), in addition to standard supportive care, were administered Methylprednisolone (0.5mg/kg per day), continuously for a minimum of 5 days, the maximum duration of treatment was left to the physician's discretion. Serial measurements on days 0, 1, 3, and 7 following methylprednisolone administration included Ferritin, Interleukin 6, C-Reactive Protein, D-dimer, and blood glucose levels, and compared with the patients on standard supportive care [11]. In addition, the date of admission, the 28-day mortality, the total number of days stayed in the hospital (Hospital Length of Stay, hLOS ), the total number of days stayed in the intensive care unit (iLOS), and the total number of days intubated were extracted from the electronic medical records of the hospitals patient information system.…”

Section: Variablesmentioning

confidence: 99%

Methylprednisolone Treatment Versus Standard Supportive Care for Adult Covid19 Mechanically Ventilated, Acute Respiratory Distress Syndrome Patients

Rahman

Nair

Din

et al. 2021

Preprint

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A myriad of symptoms presented by severely ill mechanically ventilated Covid19 patients has added pressure on the caregivers to explore therapeutic options. Systemic steroids have been reported to therapeutically benefit patients with elevated inflammatory markers, during the severe acute respiratory syndrome, and the Middle East respiratory syndrome outbreak. Covid19 disease is characterized by inflammation of the respiratory system and acute respiratory distress syndrome. Given the lack of specific treatment for Covid19, the aim of the current study was to evaluate the therapeutic benefit of methylprednisolone as an add-on treatment for mechanically ventilated hospitalized COVID19 patients with severe covid pneumonia. Data was collected retrospectively from the electronic patient medical records, and inter-rater reliability was determined to limit selection bias. Descriptive and inferential statistical methods were used to analyze the data. The variables were cross-tabulated with the clinical outcome and the Chi-Square test used to determine association between the outcomes and other independent variables. Patients. Sixty-one percent (43/70) of the Covid19 ARDS patients received standard supportive care, and the remainder were administered. methylprednisolone (40 mg daily to 40 mg q 6 hours). A 28-day all-cause mortality rate, in the methylprednisolone group was 18% (5/27, p < 0.01) significantly lower, compared to the group receiving standard supportive care (51%, 22/43). The median number of days, for the hospital length of stay (18 days), ICU-length of stay (9.5 days), and the number of days intubated (6 days) for the methylprednisolone treated group was significantly lower (p < 0.01), when compared with the standard supportive care group. Methylprednisolone treatment also reduced the C-reactive protein levels, compared to the standard care group on day 7. Our results strengthen the evidence for the role of steroids in reducing mortality, ICU LOS, and ventilator days in mechanically ventilated Covid 19 patients with respiratory distress syndrome.

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“…В России проведен ряд крупных исследований, включая создание регистров по оценке связи COVID-19 и ряда хронических заболеваний. Проанали зи рованы предикторы развития осложнений среди пациентов, перенесших COVID-19, которые указывают о неблагоприятных исходах среди лиц, имеющих одно и более ХНИЗ [8][9][10][11][12].…”

Section: результаты и обсуждениеunclassified

“…Очевидно, что карантинные меры оказали позитивное влияние на заболеваемость среди лиц с ХНИЗ. Тем не менее, по данным российских исследований коморбидность различных ССЗ и СД 2 типа оказалась неблагоприятным ФР, способствующим развитию летального исхода [10,11].…”

Section: результаты и обсуждениеunclassified

Behavioral risk factors and clinical course of cardiovascular diseases and other noncommunicable diseases during quarantine in various regions of Russia

et al. 2021

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Aim. To assess the behavioral risk factors and the clinical course of cardiovascular diseases (CVDs) and other noncommunicable diseases (NCDs) during quarantine in various regions of Russia.Material and methods. This multicenter cohort cross-sectional study included 205 men and women from 6 Russian cities. Further, 4 of them (Saransk, Nizhny Novgorod, Penza, Ulyanovsk) were combined into one group — the Volga region. The study included men and women aged 30-69 years with one or more NCDs (hypertension, coronary artery disease with or without myocardial infarction, type 2 diabetes, chronic obstructive pulmonary disease/asthma and cancer in patients receiving chemotherapy and/or radiation therapy) who were self-isolated during coronavirus disease 2019 (COVID-19) pandemic. For all patients, a questionnaire was used, which included socio-demographic parameters, behavioral risk factors, status of the underlying disease, incidence of COVID-19 and its complications. Self-assessment of the state of health was carried out using the European Quality of Life Questionnaire.Results. In every third Muscovite, the intensity of physical activity decreased, and in the groups of patients from Omsk and the Volga region, it was 45% and 43%, respectively. An increase in meal frequency and an impairment of eating habits in Moscow and Omsk was noted in 18,2% and 18,7% of participants, while in Volga region subjects, these parameters were 2 times higher (42,4%). At the same time, no significant changes of alcohol consumption and smoking was revealed in the cohorts. Hypertensive crises during a pandemic were noted in all three subgroups, but more of them were recorded in the Volga region — in every third patient (p< 0,05 compared to Moscow), in the Omsk group — in every fourth patient, and among Muscovites — no more than 5%. Clinical deterioration in patients with angina was noted in 15% of cases, while the smallest number was noted in Omsk subjects (5,3%), three times less than in other subgroups. Changes in intensity and regimen of hypoglycemic therapy were noted in patients from Omsk, while 30% of them (p< 0,05 compared with the Volga region) increased the doses of medications taken. Chronic obstructive pulmonary disease was registered in the group with the largest number of Volga region patients — 14,1% (p< 0,05 compared to Omsk), while 17% of patients in this group increased the dose of drugs. Any cancer was recorded in 13,6% of Muscovites, while in the other two groups — about 5%. The largest number of patients from the Volga region noted a health decline over the past year (30,8%), while every fifth patient from Omsk (19,6%) and 13,6% of Muscovites reported health changes.Conclusion. During quarantine and self-isolation, changes in dietary habits and physical activity decline were noted among patients with NCDs, while alcohol consumption and smoking remained practically unchanged. The change in clinical status was characterized by an increase in hypertensive crisis incidence, an increase in doses of antihypertensive and hypoglycemic medication. Depending on the region, the health decline was noted by 13-31% of patients with NCDs.

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Clinical Characteristics and Factors Associated with Poor Outcomes in Hospitalized Patients with Novel Coronavirus Infection COVID-19

Cited by 25 publications

References 18 publications

Serum biomarkers of cardiovascular complications in COVID-19

Serum biomarkers of cardiovascular complications in COVID-19

Methylprednisolone Treatment Versus Standard Supportive Care for Adult Covid19 Mechanically Ventilated, Acute Respiratory Distress Syndrome Patients

Behavioral risk factors and clinical course of cardiovascular diseases and other noncommunicable diseases during quarantine in various regions of Russia

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