Clinical characteristics and late effects in CNS tumours of childhood: Do not forget long term follow-up of the low grade tumours

Ehrstedt, Christoffer; Kristiansen, Ingela; Ahlsten, Gunnar; Casar‐Borota, Olivera; Dahl, Margareta; Libard, Sylwia; Strömberg, Bo

doi:10.1016/j.ejpn.2016.04.009

Cited by 27 publications

(35 citation statements)

References 24 publications

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“…The most common long‐term neurologic deficits observed in our study were similar to those reported in other studies, such as visual and motor deficits . For all patients, we found that long PSIs were associated with a higher incidence of long‐term ataxia and dysmetria, and long PSIs were associated with ear and vestibular dysfunction specifically in patients with brainstem LGG.…”

Section: Discussionsupporting

confidence: 90%

“…We also used increments of 3 months for PSI intervals, which were similarly reported by others. 24,27 Our study included a higher proportion of patients with supratentorial LGG, which was similarly reported by other population-based studies of LGG. A relatively low incidence of spinal cord LGGs has been reported in other studies as well.…”

Section: Discussionsupporting

confidence: 65%

“…The most common long-term neurologic deficits observed in our study were similar to those reported in other studies, such as visual and motor deficits. [22][23][24] For all patients, we found that long PSIs were associated with a higher incidence of long-term ataxia and dysmetria, and LGGs, of whom 83% experienced morbidity and 35% required orthopedic interventions for severe kyphoscoliosis at long-term follow-up. 25 Of the 15 patients with spinal cord tumors in our study, 13 (87%) had scoliosis and seven (47%) required rod placement, but their neurologic deficits did not significantly worsen over time, regardless of PSI length.…”

Section: Discussionmentioning

confidence: 81%

“…The strengths of our study include the presence of similar demographic data in our study as those in other large population‐based studies. We also used increments of 3 months for PSI intervals, which were similarly reported by others . Our study included a higher proportion of patients with supratentorial LGG, which was similarly reported by other population‐based studies of LGG.…”

Section: Discussionmentioning

confidence: 86%

See 3 more Smart Citations

Neurologic impairments from pediatric low‐grade glioma by tumor location and timing of diagnosis

Sadighi

Curtis

Zabrowksi

et al. 2018

Pediatric Blood & Cancer

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 86%

See 2 more Smart Citations

Neurologic impairments from pediatric low‐grade glioma by tumor location and timing of diagnosis

Sadighi

Curtis

Zabrowksi

et al. 2018

Pediatric Blood & Cancer

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“…Although data on LEATs have extensively been reported in the literature, studies on large series remain rare 2,4,[9][10][11][12][13] and focused mainly on clinical and survival aspects rather than on epilepsy. 40 Our nationwide retrospective study enrolled 339 patients, including both adults and children.…”

Section: Discussionmentioning

confidence: 99%

Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study

Giulioni

Marucci²,

Pelliccia³

et al. 2017

Epilepsia

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Occupational outcomes after high‐grade or low‐grade brain tumors in childhood: A Swedish, nationwide, registry‐based study

et al. 2022

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Background Survivors of pediatric brain tumors are at high risk of late complications that may affect their daily life in both short‐ and long‐term perspectives. Methods In this nationwide registry‐based study we explored the occupational outcomes, including employment, sickness or activity compensation and parental leave, in 452 individuals in Sweden, born 1988–1996, and diagnosed with a brain tumor before their 15th birthday. Their results were compared with 2188 matched controls. Results There were significant differences between cases and controls for all assessed variables. The cases had benefitted from sickness or activity compensation 11 times more often than controls (CI 7.90–15.83; p < 0.001) between 2005 and 2016. Controls were almost three times more likely to have an employment (OR 0.36; CI 0.28–0.47; p < 0.001) and nearly twice as likely to have been on parental leave (OR 0.56; CI 0.39–0.80; p = 0.002). Although cases treated for high‐grade tumors typically fared worse than those treated for low‐grade tumors, significant differences for all assessed variables were also observed for cases treated for a low‐grade tumor compared with controls. Conclusions Our findings emphasize the need for follow‐up programs for all brain tumor diagnoses, not only those known to be at most risk. This is evident, for example, from the high number of cases who received sickness or activity compensation.

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Clinical characteristics and late effects in CNS tumours of childhood: Do not forget long term follow-up of the low grade tumours

Cited by 27 publications

References 24 publications

Neurologic impairments from pediatric low‐grade glioma by tumor location and timing of diagnosis

Neurologic impairments from pediatric low‐grade glioma by tumor location and timing of diagnosis

Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study

Occupational outcomes after high‐grade or low‐grade brain tumors in childhood: A Swedish, nationwide, registry‐based study

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