Clinical characteristics and long-term prognosis of ischemic and non-ischemic cardiomyopathy

Abstract

Objectives The different etiology of HF has different prognostic risk factors. Prognosis assessment of ICM and NICM has important clinical value. This study is aimed to explore the predicting factors for ICM and NICM. Methods 1082 HFrEF patients were retrospectively enrolled from Jan. 01, 2016 to Dec. 31, 2017. On Jan. 31, 2019, 873 patients were enrolled for analysis excluding incomplete, unfollowed, and unexplained data. The patients were divided into ischemic and non-ischemic group. The differences in clinical characteristics and long-term prognosis between the two groups were analyzed, and multivariate Cox analysis was used to predict the respective all-cause mortality, SCD and rehospitalization of CHF. Results 873 patients aged 64(53,73) were divided into two groups: ICM (403, 46.16%) and NICM. At the end, 203 died (111 in ICM, 54.68%), of whom 87 had SCD (53 in ICM, 60.92%) and 269 had rehospitalization for HF(134 in ICM, 49.81%). Independent risk factors affecting all-cause mortality in ICM: DM, previous hospitalization of HF, age, eGFR, LVEF; for SCD: PVB, eGFR, Hb, revascularization; for readmission of HF: low T3 syndrome, PVB, DM, previous hospitalization of HF, eGFR. Otherwise; factors affecting all-cause mortality in NICM: NYHA III-IV, paroxysmal AF/AFL, previous hospitalization of HF, β-blocker; for SCD: low T3 syndrome, PVB, nitrates, sodium, β-blocker; for rehospitalization of HF: paroxysmal AF/AFL, previous admission of HF, LVEF. Conclusions Both all-cause mortality and SCD in ICM is higher than that in NICM. Different etiologies of CHF have different risk factors affecting the prognosis.

The predictive role of systemic immune-inflammation index in non-ischemic cardiomyopathy

“…21 Similar to the results of previous studies, our study showed a significant relationship between a high BNP value and mortality. 24 However, the difficulty of access to this parameter and its high cost limits its use in clinical practice. In addition, BNP values may be affected by differences in age, gender, body weight, and laboratory kits.…”

Clinical Significance of Chitotriosidase in Outpatients with Advanced Heart Failure

“…Many studies have shown that IHF has a worse prognosis than NIHF and the parameters such as advanced age, poor NYHA functional class and impaired renal functions are associated with the severity and prognosis of HF 34 35. In particular, lower LVEF is a major risk factor for cardiac and all-cause mortality 36.…”

Changes in extracellular matrix in failing human non-ischemic and ischemic hearts with mechanical unloading

“…Ischemic cardiomyopathy (ICM) results from coronary artery disease (CAD) and myocardial infarction (MI) while non-ischemic cardiomyopathy (NICM) has a variety of etiologies including genetic, viral, toxic and idiopathic. Earlier epidemiological surveys and large-scale clinical trials suggested that the prognosis of ICM patients is worse than NICM patients [2,3], yet the guideline-directed therapy for systolic dysfunction remains the same regardless of etiology. [4] Thus, a better understanding of disease mechanisms and developing etiology-specific therapeutic strategies are critical to improve patient care.…”