Clinical characteristics and outcome in dogs with small cell T‐cell intestinal lymphoma

Couto, K. M.; Moore, Peter F.; Zwingenberger, Allison L.; Willcox, Jennifer L.; Skorupski, Katherine A

doi:10.1111/vco.12384

Cited by 29 publications

(21 citation statements)

References 36 publications

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“…In addition, an immunohistochemistry (IHC) or PCR for antigen receptor rearrangements (PARR) was not performed in our population. Recently, two studies described low-grade lymphoma in dogs that underwent endoscopic evaluation for gastrointestinal signs [ 34 , 35 ]. In our cases, it was not possible to rule out that in the NRE group there were included also low-grade lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Immunosuppressant-Responsive Enteropathy and Non-Responsive Enteropathy in Dogs: Prognostic Factors, Short- and Long-Term Follow Up

Benvenuti

Pierini

Bottero³

et al. 2021

Animals

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A multicentre prospective study was performed to assess whether clinical, hematobiochemical, endoscopic and histopathological parameters were associated with mortality, clinical response and relapse of disease in short- and long-term follow-up of a total of 165 dogs with chronic inflammatory enteropathy, of which 150 had immunosuppressant responsive enteropathy (IRE), and 15 had non-responsive enteropathy (NRE) dogs. Clinical severity (CCECAI) was evaluated from presentation (T0) to 18 months (T18) from diagnosis. T0 body condition score (BCS), selected haematological parameters and endoscopic and histopathological scores were evaluated. Presence/absence of histopathological duodenal lesions was recorded. Responders were evaluated using CCECAI at T1. Relapse was evaluated from T3 to T18. Long-term responders included dogs who responded at T1 and showed no relapse. Dogs were divided into responders/non-responders, survivors/non-survivors and relapsed/non-relapsed. At T1, 15/165 dogs (9%) were considered NRE. Sixteen dogs (11%) were considered relapsed at T3, 8% at T6 and 10% at T12, and none of 96 dogs relapsed at T18. NREs showed significantly lower BCS than IREs. Non-survivors showed a significantly lower serum albumin concentration and BCS than survivors. Non-responders, relapsed or non-survivors had higher presence of lacteal dilatation compared to long-term responders. Dogs with IRE showed a good clinical course with a low relapse rate, with only a few dogs in the NRE group. Reduction of BCS, albumin and lacteal dilatation at diagnosis may be considered negative prognostic factors for response, mortality and long-term disease remission.

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Section: Discussionmentioning

confidence: 99%

Immunosuppressant-Responsive Enteropathy and Non-Responsive Enteropathy in Dogs: Prognostic Factors, Short- and Long-Term Follow Up

Benvenuti

Pierini

Bottero³

et al. 2021

Animals

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“…Sixteen percent of dogs with multicentric lymphoma have hypocobalaminemia, and this finding is associated with a poor outcome . A higher rate of hypocobalaminemia (40% and 71%) is seen in dogs with low‐grade (lymphocytic) GI lymphoma . It is presumed that the hypocobalaminemia in dogs with lymphoma is a consequence of the ileal infiltration with neoplastic lymphocytes hypothetically resulting in a disruption of the receptor‐mediated GI uptake of cobalamin …”

Section: Conditions Associated With a Suboptimal Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

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Disorders of cobalamin (vitamin B 12 ) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with serum folate concentration, is routinely performed as a diagnostic test in clinical practice. While the detection of hypocobalaminemia has therapeutic implications, interpretation of cobalamin status in dogs can be challenging. The aim of this review is to define hypocobalaminemia and cobalamin deficiency, normocobalaminemia, and hypercobalaminemia in dogs, describe known cobalamin deficiency states, breed predispositions in dogs, discuss the different biomarkers of importance for evaluating cobalamin status in dogs, and discuss the management of dogs with hypocobalaminemia. K E Y W O R D S cobalamin deficiency, cubam receptor, folate, homocysteine, hypercobalaminemia, hypocobalaminemia, methylmalonic acid, vitamin B 12

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“…4 However, lymphoma, the most common primary intestinal neoplasia in dogs, predominately affects the duodenum (85% of dogs) compared to the ileum (55% of dogs). 36 However, this only applies to small cell lymphoma and does not include other types of intestinal lymphoma or neoplasia. Additionally, histopathologic diagnosis and severity were not evaluated as risk factors in our study, which might have affected the outcome.…”

Section: Discussionmentioning

confidence: 99%

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein‐losing enteropathy

Economu

Chang

Priestnall

et al. 2021

Veterinary Internal Medicne

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Background The effect of assisted enteral feeding on treatment outcome in dogs with protein‐losing enteropathy (PLE) is unknown. Objectives To determine if dogs with inflammatory PLE that had an enteral feeding tube placed had better outcome vs dogs with inflammatory PLE without a feeding tube. Animals Fifty‐seven dogs with inflammatory PLE. Methods A retrospective study at a UK referral hospital identified dogs with inflammatory PLE using a standard diagnostic criterion. Positive outcome was defined as survival greater than 6 months or death unrelated to PLE and negative outcome as death related to PLE within 6 months of diagnosis. Several variables were assessed to identify factors for positive outcome using logistic regression. Results Thirty‐five (61%) and 22 (39%) dogs had a positive and negative outcome at 6 months, respectively. Of the 21 dogs that had a feeding tube placed within 5 days of gastrointestinal biopsy, 16 (76%) had a positive outcome and 5 (24%) had a negative outcome. Dogs treated with dietary treatment alone (P = .002) and dogs with an enteral feeding tube (P = .006) were significantly associated with a positive outcome. When stratified by treatment, assisted enteral feeding was significantly associated with a positive outcome in dogs treated with concurrent immunosuppressive treatment (P = .006), but there was insufficient data to evaluate dogs treated with dietary treatment alone. Conclusions and Clinical Importance Assisted enteral feeding in dogs with inflammatory PLE could be associated with improved treatment outcome, especially in those receiving immunosuppressive treatment, and should be considered in the treatment plan of these dogs.

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Clinical characteristics and outcome in dogs with small cell T‐cell intestinal lymphoma

Cited by 29 publications

References 36 publications

Immunosuppressant-Responsive Enteropathy and Non-Responsive Enteropathy in Dogs: Prognostic Factors, Short- and Long-Term Follow Up

Immunosuppressant-Responsive Enteropathy and Non-Responsive Enteropathy in Dogs: Prognostic Factors, Short- and Long-Term Follow Up

Review of cobalamin status and disorders of cobalamin metabolism in dogs

The effect of assisted enteral feeding on treatment outcome in dogs with inflammatory protein‐losing enteropathy

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