Clinical characteristics and outcome of mucormycosis: A multi-center retrospective analysis in Saudi Arabia over 11 years

Abanamy, Reem; Alsaud, Abdulrahman; Alabdulali, Rawan; Alsobaie, Mohammed; Alalwan, Bassam; Aljohani, Sameera; Alshieban, Saeed; Turkistani, Hanan; Almohaizeie, Abdullah; Bosaeed, Mohammad; Alrabiah, Fahad

doi:10.1016/j.ijregi.2022.07.004

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…In Iran and India, DM has been consistently identified as the most frequently reported risk factor in patients with MCM, while in Europe and USA, HM has emerged as the most common underlying disease [ 4 , 31 , 32 , 33 , 34 , 35 ]. A recent 11-year multi-center study conducted in Saudi Arabia showed comparable proportions of DM and HMs among the patient population diagnosed with MCM (48% and 42.4%, respectively) [ 36 ]. In our study, almost two-thirds of our patients had an HM and one-third had DM.…”

Section: Discussionmentioning

confidence: 99%

“…Whether MCM was caused by a direct trauma from the SCD remains uncertain. Interestingly, two studies from Saudi Arabia showed that the most common site of infection was cutaneous MCM [ 36 , 67 ]. Elzein et al showed a notable occurrence of cutaneous MCM associated with significant trauma, particularly from motor vehicle collisions (38.9%) [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

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Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon

Allaw,

Zakhour,

Nahhal

et al. 2023

JoF

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Mucormycosis (MCM) is a serious invasive fungal disease (IFD) that is associated with high mortality, particularly in immunocompromised patients. A global surge in MCM cases was reported with the COVID-19 pandemic. We analyzed all recorded cases of MCM at the American University of Beirut Medical Center (AUBMC), a tertiary care center in Lebanon, over 14 years. We aimed to identify the incidence, seasonal variation, clinical characteristics of the patients, and predictors of mortality. We conducted a retrospective chart review between 1 January 2008 and 1 January 2023. All patients with proven or probable MCM were included in the study. Proven or probable MCM was defined by positive histopathology and/or positive cultures. A total of 43 patients were identified as having MCM. Their median age was 53 years, and the majority were males (58.1%). Most of the cases were diagnosed in the autumn season. In total, 67.4% of the patients had hematological malignancies (HMs), and 34.9% had uncontrolled diabetes mellitus (DM). The most common site of involvement was rhino-orbital-cerebral MCM (ROCM) (74%). The annual cases of MCM per 100,000 patient days increased markedly during the years of the COVID-19 pandemic (from 0 to 4.4 cases/100,000 patient days to 7.5 cases/100,000 during 2020 and 2021). Liposomal amphotericin (Ampho) B was used as a first-line agent in most of the patients (86%). The median duration of total in-hospital antifungal therapy was 21 days and 51.2% of the patients received step-down therapy with azoles. Surgical debridement and isolated ROCM were significantly associated with survival (p-value: 0.02 and <0.001, respectively). All-cause mortality was 46.7%, with chronic renal disease being significantly associated with mortality (p-value < 0.05). The incidence of MCM has been increasing at our institution, particularly since the COVID-19 pandemic. Early diagnosis, treatment, and surgical debridement improve patient outcomes and overall survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon

Allaw,

Zakhour,

Nahhal

et al. 2023

JoF

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“…The burden of mucormycosis is increasing worldwide, and there has been a transition in the epidemiology of mucormycosis in recent years with the emergence of new risk factors and causative agents. However, in our Saudi population, the discovered cases and the overall prevalence were low [5]. Herein, we present a case of mucormycosis infection aiming to illustrate the clinical characteristics and management strategy and to add the case to the literature.…”

Section: Introductionmentioning

confidence: 96%

Unmasking the Deadly Fungus: A Case Report of Rhino-Orbital-Cerebral Mucormycosis in a Diabetic Patient With Unusual Presentation

Aljoaid¹,

Khayat²,

Alkhotani³

2023

Cureus

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Mucormycosis (zygomycosis) is a rare, rapidly progressive fungal infection that is opportunistic and usually affects immunocompromised individuals, most commonly patients with diabetes mellitus. It is a fatal infection that requires high clinical suspicion and early disease identification. The global burden of mucormycosis is unknown as it is a rare disease. However, the burden of mucormycosis is increasing worldwide, with the emergence of new risk factors and causative agents. In the Saudi population, the discovered cases and the overall prevalence were low. Herein, we present a case of mucormycosis infection aiming to illustrate the clinical characteristics and the management strategy, besides adding another case to the literature.

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Invasive mucormycosis in a tertiary care hospital in the western region of Saudi Arabia: 11-year retrospective chart review from 2009 to 2019

Almarhabi

Al-Asmari

Munshi

et al. 2022

Journal of Infection and Public Health

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Clinical characteristics and outcome of mucormycosis: A multi-center retrospective analysis in Saudi Arabia over 11 years

Cited by 5 publications

References 23 publications

Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon

Mucormycosis: A 14-Year Retrospective Study from a Tertiary Care Center in Lebanon

Unmasking the Deadly Fungus: A Case Report of Rhino-Orbital-Cerebral Mucormycosis in a Diabetic Patient With Unusual Presentation

Invasive mucormycosis in a tertiary care hospital in the western region of Saudi Arabia: 11-year retrospective chart review from 2009 to 2019

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