Clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 infection at Toulouse University hospital (France). Results from the Covid-clinic-Toul cohort

Abstract

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide from epicenter of Wuhan, China since December 2019. The aim of our study was to describe the clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 pneumonia at the Toulouse university hospital, France. Patients and methods We selected the patients included from March 7, 2020 to April 20, 2020 in the retrolective Covid-clinic-Toul cohort that follows all hospitalized patients with SARS-CoV-2 infection at the Toulouse Hospital. Cases were confirmed by real-time reverse transcriptase polymerase chain reaction. We report demographics, clinical, biological and radiological features, as well as unfavorable outcome at Day 14 after admission (admission in an intensive care unit, mechanical ventilation, death). Results Among 263 hospitalized patients, the median age was 65 years and 155 (58.9%) were males. Two hundred and twenty-seven patients (86.3%) had at least one comorbidity. The median time from first symptom to hospital admission was 7.0 days (interquartile range: 4–10). On day 14 after admission, 111 patients (42.2%) had been transferred to intensive care unit (ICU), including 50 (19.0%) on Day 1; 61 (23.1%) needed mechanical ventilation and 19 patients (7.2%) had died. Patients admitted to ICU at Day 1 of admission ( n = 50) were more frequently men (66.0% vs 57.3%), smokers (25.0% vs 7.1%), with obesity (42.0% vs 24.7%) and had a higher mean level of C-reactive protein (median: 110.9 mg/L vs 46.2 mg/L). Conclusion This cohort provides epidemiological data on SARS-CoV-2 in hospitalized patients in a University hospital in the South of France.

Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry

“…Recent studies have shown that a renin-angiotensin system imbalance due to COVID-19 can exacerbate the inflammatory state and result in a more severe clinical course of the disease (Lanza et al, 2020;Sanchis-Gomar et al, 2020). Whereas in previous studies obesity was a risk factor for mortality (Docherty et al, 2020;Goyal et al, 2020;Jourdes et al, 2020;Matsunaga et al, 2020;Simonnet et al, 2020), this was not observed in our sample. This may be due to a limitation of the study, in that obesity was not directly measured by weight or body mass index, but rather was gathered from medical records, which may have ed to underreporting.…”

“…The overall mortality was 22.0%, which is similar to that found in studies in Spain and Italy (Borobia et al, 2020;Giacomelli et al, 2020), but higher than in studies in the US, Asia, France, Iran, Japan, Russia, Turkey, and the Democratic Republic of the Congo (Chen et al, 2020;Goyal et al, 2020;Jourdes et al, 2020;Matsunaga et al, 2020;Munblit et al, 2020;Myers et al, 2020;Nachega et al, 2020;Nikpouraghdam et al, 2020;Quisi et al, 2020;Richardson et al, 2020;Yu et al, 2020).…”

Clinical status of consulting COVID-19 cases and fatal outcome in a Cameroon regional hospital

“…The present study reveals a delay in seeking care after the onset of first symptoms and consultation ranging from 0.0 days to 45.0 days with a mean of 7.2 days. Despite a difference in time period and target population, other studies conducted in France and China have found a similar mean duration of approximately 7 days [ 3 , 5 , 26 ]. Data were not collected to investigate reasons for the choice of delays to seeking care after the onset of symptoms, as in other published studies.…”

Change of critical COVID-19 disease in time

“…In the study of Jourdes et al has been reported that 42. 2% of the patients in the inpatient service were transferred to the intensive care unit (10). In COVID-19 disease, patients who need intensive care follow-up are usually over 60 years old and with additional disease (11).…”