Clinical characteristics and outcomes in renal transplant recipients with renal cell carcinoma in the native kidney

Abstract

Background/AimsWe investigated the incidence and clinical characteristics of renal cell carcinoma (RCC) in the native kidney of renal transplant recipients.MethodsBetween 1991 and 2010, 1,425 patients underwent kidney transplantation at our institution. We retrospectively evaluated the clinical features and outcomes in renal transplant patients with RCC in the native kidney after renal transplantation.ResultsThe patients included three males and two females with a mean age of 63 years (range, 52 to 74). The incidence of RCC was 0.35%. The median interval between renal transplantation and RCC occurrence was 16.2 years (range, 9 to 20). All of our patients with RCC had developed renal cysts either before (n = 3) or after (n = 2) renal transplantation. The mean duration of dialysis was 12 months (range, 2 to 39). Of the five patients, four underwent dialysis treatment for less than 8 months. All the RCCs were low grade at the time of diagnosis. Four patients underwent radical nephrectomy, and one patient refused the operation. The four patients who underwent radical nephrectomy showed no evidence of local recurrence or distant metastasis during the median follow-up of 2.9 years. However, the patient who did not undergo surgery developed spinal metastasis from the RCC 6 years later.ConclusionsThis study suggests that the follow-up period is an important factor for the development of RCC in renal transplant recipients, and more vigorous screening with a longer follow-up period is required in renal transplant recipients.

Papillary renal cell carcinoma with sarcomatoid differentiation in a native kidney of transplant recipient: A case report and review of literature

“…The most common variant in a transplant recipient is clear cell, but the incidence of papillary type is more common than in nontransplant. [ 14 ] True incidence and prognosis of RCC with SD in a transplant recipient is still not known. In a large series of RCC of 101 patient in nontransplant patients, SD was found in about 8%.…”

Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report

“…Many authors claimed the importance of screenings for several neoplastic entities in the transplanted population [24][25][26][27], recommending vigorous surveillance programs with long-term follow-up, as malignancies can develop even after more than 10 years from the transplant. Even if importance of screening programs is undoubted in such a context, still, precise guidelines are not yet available, as the medical community has not reached a full consensus.…”

Erythrocyte glucose-6-phosphate dehydrogenase activity and risk of gestational diabetes

“…The subjects were diagnosed as GDM if at least two of the four OGTT values were reached or exceeded the above-mentioned values [15]. If only one of four values was impaired, the subjects were classified as impaired glucose tolerance (IGT) [16,17]. Subjects with normal OGTT values were considered in normal glucose tolerance (NGT) group.…”