Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study

Abstract

Background Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina. Methods Multicenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU). Results A total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16–2.81), hypertension (OR 3.21; 95%CI 2.08–4.95), obesity (OR 2.38; 95%CI 1.51–3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20–9.92) and lymphopenia (OR 3.21; 95%CI 2.08–4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63–4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97–5.16) and lymphopenia (OR 2.65; 95%CI 1.64–4.27). Conclusions This cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.

Age Dependent Epidemic Modeling of COVID-19 Outbreak in Kuwait, France, and Cameroon

“…For example, on the site of Johns Hopkins University dedicated to COVID-19 [ 1 ], data clearly shows this influence on the case fatality rate corresponding to the cumulative deaths recorded 5 months after the beginning of the outbreak (12 May 2020) vs. the median age of many countries in 2017 ( Figure 1 ). This first observation has been confirmed by many studies in different countries [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ] such as in France ( Figure 2 ), and we will confirm in this paper that the age of the patients suffering from COVID-19 is a good predictor of severity.…”

Evaluating the characteristics of patients with SARS-CoV-2 infection admitted during COVID-19 peaks: A single-center study

“…Other frequent clinical complications reported by Zhong [ 48 ] included dyspnea, fatigue, and muscle aches [ 48 ]. In Cordova et al's study [ 52 ], fever, cough, and dyspnea and in Bernheim et al's study [ 53 ], fever, cough, muscle pain, and fatigue were the most prevalent symptoms. Dizziness and sore throat were among the uncommon symptoms of COVID-19 in all peaks, which corroborates the study of Sharifi-Razavi et al [ 54 ].…”

“…The most common radiological finding in all peaks was grand glass, as similarly reported by Cordova et al and Borges al. [ 52 , 59 ]. After GGO, consolidation had the highest prevalence (14.6%) in the third peak.…”

Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become one of the largest known pandemic in human history affecting more than 233 million people across the globe [ 1 ]. Although the majority of individuals experience mild symptoms, approximately 5–15% develop respiratory failure and require invasive mechanical ventilation (IMV) [ 2 – 6 ]. Earlier reports of patients with coronavirus disease 2019 (COVID-19) on IMV described poor outcomes, with mortality rates as high as 45–74%, and 50% of patients requiring prolonged IMV (> 2 weeks) [ 4 , 7 – 11 ].…”