Clinical Characteristics and Outcomes of Patients With COVID-19–Associated Acute Respiratory Distress Syndrome Who Underwent Lung Transplant

Abstract

IMPORTANCELung transplantation is a potentially lifesaving treatment for patients who are critically ill due to COVID-19-associated acute respiratory distress syndrome (ARDS), but there is limited information about the long-term outcome.OBJECTIVE To report the clinical characteristics and outcomes of patients who had COVID-19-associated ARDS and underwent a lung transplant at a single US hospital.

Gamma-glutamyltransferase is a strong predictor of secondary sclerosing cholangitis after lung transplantation for COVID-19 ARDS

“…In recent reports, it represented 7-29% of the transplant volume in institutions offering transplantation for ARDS. 2 , 3 , 4 …”

“…LTx for post-COVID-19 ARDS has shown promising short- and mid-term survival. 2 , 22 Several centers have reported liver damage with features of SSC-CIP as a late complication in these patients, but comprehensive data are still lacking. In this multicenter-study, we therefore aimed to i) analyze the incidence of SSC-CIP in patients after LTx for COVID-19 ARDS and to ii) explore predictive factors which could aid in patient selection and therefore avoid this severe complication.…”

Global scientific outputs of extracorporeal membrane oxygenation in COVID-19: A bibliometric overview

“…These findings suggest that the need for intensive care and ECMO in pediatric patients also increased due to the increase in the number of pediatric patients in the course of the pandemic and the development of MIS-C. Further, it is a normal result that dexamethasone is a trending topic, its use has become widespread after the effectiveness of steroid treatment in COVID-19 has been demonstrated. 29 Various data on the development of COVID-19 in immunosuppressed lung transplant patients and lung transplantation due to COVID-19-related respiratory failure have been published in the literatüre 30 , 31 . ECMO, which acts as a bridge until transplantation, is frequently used, especially in patients undergoing lung transplantation for COVID-19.…”

New Organ Transport Support Technology is a Game Changer

“…A recently published single‐center case series from Northwestern University in Chicago described the clinical characteristics, intraoperative procedures and postoperative complications of a cohort of 30 lung transplant recipients who had COVID‐19–associated ARDS 2 . The patients had severe lung damage, and the cohort was characterized by a high incidence of pulmonary necrosis, bronchiectasis, ventilator‐associated pneumonia caused by multidrug‐resistant pathogens and pulmonary hypertension with concomitant right ventricular dysfunction.…”