Clinical characteristics and outcomes of patients with 2009 influenza A(H1N1) virus infection with respiratory failure requiring mechanical ventilation

Nin, Nicolás; Soto, Luis; Hurtado, Javier; Lorente, José A.; Buroni, María; Arancibia, Francisco; Ugarte, Sebastián; Bagnulo, Homero; Cardinal, Pablo; Bugedo, Guillermo; Echevarría, E. Martín; Deicas, Alberto; Ortega, Carlos; Frutos‐Vivar, Fernando; Esteban, Andrés

doi:10.1016/j.jcrc.2010.05.031

Cited by 63 publications

(53 citation statements)

References 11 publications

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“…Nin et al 9 reported that only 7% of patients diagnosed with H1N1 infection and admitted to the ICU were >65 years of age. Other studies that have reported the patient age to be 27-44 years support this finding 6,7,11,12,15,16 .…”

Section: Discussionmentioning

confidence: 99%

“…The majority of the patients with H1N1 infection had a risk factor such as a co-morbidity or were pregnant 5,6,8,9,12,[14][15][16][17] . In the current study, 60.9% of cases had an accompanying risk factor, which is a similar finding in previously mentioned studies.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies of H1N1 infected patients with acute respiratory symptoms have shown infiltration rates of 31.8%-100% based on pulmonary radiographs 8,9,24 . In the current study, although all the patients were admitted to ICU with respiratory problems, 60.9% were determined to have unilateral or bilateral infiltrations.…”

Section: African Health Sciencesmentioning

confidence: 99%

“…Although early symptoms similar to seasonal influenza were observed, cases of H1N1 infection progressed to viral pneumonia, respiratory failure, hypoxia, and organ failure resulting in death [6][7][8] . Some cases were treated in the ICU, and mortality was reported to be 5%-50% [7][8][9][10][11][12] . This retrospective study describes the demographic characteristics, clinical features, and outcome of adult patients with severe H1N1 virus infection who were treated in the ICU for respiratory failure from November 2009 to February 2010.…”

Section: Introductionmentioning

confidence: 99%

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A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009–2010 pandemic

Nermin¹,

İşçimen²,

Zeynep³

et al. 2015

Afr H. Sci.

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Background: H1N1 influenza A virus infections were first reported in April 2009 and spread rapidly, resulting in mortality worldwide. The aim of this study was to evaluate patients with H1N1 infection treated in the intensive care unit (ICU) in Bursa, Turkey. Methods: Demographic characteristics, clinical features, and outcome relating to H1N1 infection were retrospectively analysed in patients treated in the ICU. Results: Twenty-three cases of H1N1 infection were treated in the ICU. The mean age of patients was 37 years range: (17-82). Fifteen patients were female (65.2%). The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 19 range: (5-39). The most common symptoms were dyspnea (73.9%), fever (69.6%), and cough (60.9%). Mechanical ventilation was required for all patients. Oseltamivir and antibiotics were administered to all patients. Six (26.1%) patients died. APACHE II scores were higher in the deceased 28.5 range: vs. 14 range: in survivors; p = 0.013). Conclusion: When compared to the literature, the demographic, epidemiological, and clinical characteristics were similar in the cases we encountered. The mortality rate was high despite the use of appropriate treatment. We believe that the high mortality is related to higher APACHE II scores. The H1N1 virus should be considered in community acquired pneumonia, especially in younger patients presenting with severe pneumonia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: African Health Sciencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009–2010 pandemic

Nermin¹,

İşçimen²,

Zeynep³

et al. 2015

Afr H. Sci.

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“…The success rate was very different between the studies, ranging from 23% to 76%, which highlights that several factors probably influenced the different patient outcomes. [78][79][80][81][82] Estenssoro et al 78 studied 337 mechanically ventilated patients with ARF due to H1N1 pneumonia. Sixty-four received NIV, and despite the relative low success rate, NIV was associated with better outcomes, possibly because the attending physicians selected NIV for the less hypoxemic patients.…”

Section: Risky Business Pandemic Diseasesmentioning

confidence: 99%

Behind a Mask: Tricks, Pitfalls, and Prejudices for Noninvasive Ventilation

Nava

2013

Respir Care

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It is difficult to exactly date the beginning of mechanical ventilation, but there are no doubts that noninvasive ventilation (NIV) was the first method of ventilatory support in clinical practice. The technique had a sudden increase in popularity, so that it is now considered, according to criteria of evidence-based medicine, the first-line treatment for an episode of acute respiratory failure in 4 pathologies (the Fabulous Four): COPD exacerbation, cardiogenic pulmonary edema, pulmonary infiltrates in immunocompromised patients, and in the weaning of extubated COPD patients. The so-called emerging applications are those for which the evidence has not achieved level A, mainly because the number or sample size of the published studies does not allow conclusive meta-analysis. These emerging applications are the post-surgical period, palliation of dyspnea, asthma attack, obesity hypoventilation syndrome, and to prevent extubation failure. Potentially "risky business" uses include for respiratory failure from pandemic diseases and ARDS, where probably the "secret" for success is early use. Healthcare is rich in evidence-based innovations, yet even when such innovations are implemented successfully in one location, they often disseminate slowly, if at all, so their clinical use remains limited and heterogeneous. The low rate of NIV use in some hospitals relates to lack of knowledge about or experience with NIV, insufficient confidence in the technique, lack of NIV equipment, and inadequate funding. But NIV use has been increasing around the world, thanks partly to improved technologies. The skill and confidence of clinicians in NIV have improved with time and experience, but NIV is and should remain a team effort, rather than the property of a single local "champion," because, overall, NIV is beautiful!

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Investing in antibiotics to alleviate future catastrophic outcomes: What is the value of having an effective antibiotic to mitigate pandemic influenza?

et al. 2019

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Over 95% of post‐mortem samples from the 1918 pandemic, which caused 50 to 100 million deaths, showed bacterial infection complications. The introduction of antibiotics in the 1940s has since reduced the risk of bacterial infections, but growing resistance to antibiotics could increase the toll from future influenza pandemics if secondary bacterial infections are as serious as in 1918, or even if they are less severe. We develop a valuation model of the option to withhold wide use of an antibiotic until significant outbreaks such as pandemic influenza or foodborne diseases are identified. Using real options theory, we derive conditions under which withholding wide use is beneficial, and calculate the option value for influenza pandemic scenarios that lead to secondary infections with a resistant Staphylococcus aureus strain. We find that the value of withholding an effective novel oral antibiotic can be positive and significant unless the pandemic is mild and causes few secondary infections with the resistant strain or if most patients can be treated intravenously. Although the option value is sensitive to parameter uncertainty, our results suggest that further analysis on a case‐by‐case basis could guide investment in novel agents as well as strategies on how to use them.

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Clinical characteristics and outcomes of patients with 2009 influenza A(H1N1) virus infection with respiratory failure requiring mechanical ventilation

Cited by 63 publications

References 11 publications

A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009–2010 pandemic

A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009–2010 pandemic

Behind a Mask: Tricks, Pitfalls, and Prejudices for Noninvasive Ventilation

Investing in antibiotics to alleviate future catastrophic outcomes: What is the value of having an effective antibiotic to mitigate pandemic influenza?

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