Clinical characteristics and outcomes of patients with severe acute respiratory infections (SARI): results from the Egyptian surveillance study 2010–2014

Hatem, Ashraf; Mohamed, Sherif; Elhassan, Usama E. Abu; Ismael, Eman A. M.; Rizk, Magda; Elkholy, Amany; El-Harras, Mohamed

doi:10.4081/mrm.2019.12

Cited by 3 publications

(3 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a large Egyptian surveillance study that addressed the epidemiological patterns of severe ARI due to viruses and atypical bacteria in both children and adult population conducted over a 4 year-period Hatem et al reported that no coronavirus was detected among their studied group [47].…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies in Egypt showed that prevalence of Adenovirus infection ranged from 4.5% to 16.7% [19,20,37,47]. Kajon et al [46] investigated 165 respiratory Adenovirus in Argentina, Chile and Uruguay, they reported that the highest prevalence 48.3% was in the age group 0-5 months followed by the age group 6-11 months 34.2% while the least prevalence was in the age group 2-5 years 4.7% with a higher exposure of males 67.5.2% than females 32.5%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human coronavirus OC43 and other respiratory viruses from acute respiratory infections of Egyptian children

Naga

Elsawaf

Elzalabany

et al. 2020

AMicr

View full text Add to dashboard Cite

Respiratory infections have a significant impact on health worldwide. Viruses are major causes of acute respiratory infections among children. Limited information regarding its prevalence in Egypt is available. This study investigated prevalence of 10 respiratory viruses; Adenovirus, influenza A, B, respiratory syncytial virus (RSV), Parainfluenza virus (PIV)type 1-4, enterovirus, and human coronavirus OC43 (HCoV-OC43) among children in Alexandria, Egypt presenting with acute lower respiratory tract infections. The study was conducted on children <14 years of age selected from ElShatby Pediatric Hospital, Alexandria University, Egypt. One hundred children presenting during winter season with influenza-like illness were eligible for the study. Oropharyngeal swabs were collected and subjected to viral RNA and DNA extraction followed by polymerase chain reaction. Viral infections were detected in 44% of cases. Adenovirus was the most common, it was found in 19% of the patients. Prevalence of PIV (3 and 4) and enterovirus was 7% each. Prevalence of RSV and HCoV-OC43 was 5% and 3% respectively. Two percentage were Influenza A positive and 1% positive for influenza B. Mixed viral infection was observed in 7%.To the best of our knowledge, this is the first report of the isolation of HCoV-OC43 from respiratory infections in Alexandria, Egypt.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Human coronavirus OC43 and other respiratory viruses from acute respiratory infections of Egyptian children

Naga

Elsawaf

Elzalabany

et al. 2020

AMicr

View full text Add to dashboard Cite

show abstract

“…Studies from Egypt indicated that viruses were the main causes of SARI in children < 16 years in the pre-pandemic phase with RSV and Adenovirus the being most common viruses and Influenza less common 29 , 30 . The same pattern was found in this study where influenza came third cause of SARI during the late phase of the pandemic.…”

Section: Discussionmentioning

confidence: 99%

Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022

Kandeel,

Fahim,

Deghedy

et al. 2023

Sci Rep

View full text Add to dashboard Cite

In late 2022, severe acute respiratory infections (SARI) surveillance reported an abrupt increase in non-COVID-19 infections among children after three years of drastic reductions. Signals of increased absenteeism due to respiratory symptoms among primary and preparatory school children were detected by Event-Based Surveillance. We conducted a hospital-based survey of children who were admitted with SARI to identify the causative pathogen(s) and estimate the burden of infection. A survey was conducted among children < 16 years in 21 referral hospitals in the three governorates with the highest SARI rates. Patients’ demographics, clinical symptoms, and severity were collected from medical records using a line list. Patients were swabbed and tested for a panel of 33 respiratory pathogens by RT-PCR at the Central Laboratory in Cairo. Descriptive data analysis was performed for demographic data. Patients’ characteristics were compared by causative agents’ clinical picture and severity using Chi2 with a p < 0.05 significance. Overall, 317 patients were enrolled, 58.3% were ≤ 1 year of age, 61.5% were males. Of 229 (72.7%) of positively tested patients, viruses caused 92.1% including RSV 63.8%, Rhinovirus 10.0%, Influenza 9.2%, Adenovirus 5.2%, and 1.3% co-infected with two viruses. Bacteria caused 3.5% of cases and 4.4% had mixed viral-bacterial infections. Rhinovirus was the most common cause of death among children with SARI, followed by RSV (8.7% and 1.4%), whereas influenza and Adenovirus did not result in any deaths. Patients with viral-bacterial infections are more likely to be admitted to ICU and die at the hospital than bacterial or viral infections (60% and 20% vs. 31.8% and 1.9% vs. 12.5% and 12.5%, p < 0.001). Viruses particularly RSV are the leading cause of SARI causing significant health problem among children < 16 years in Egypt. Bacterial on top of viral infection can worsen disease courses and outcomes. Studies are required to estimate the SARI burden accurately among Egyptian children and a comprehensive approach tailored to Egypt is necessary to reduce its burden.

show abstract

Antioxidants as adjuvant therapy in the treatment of community-acquired pneumonia

Youssef,

Elmokadem,

Samy

et al. 2024

Futur J Pharm Sci

View full text Add to dashboard Cite

Background Community-acquired pneumonia remains a major health concern, characterized by significant morbidity and mortality. The underlying pathophysiology of community-acquired pneumonia involves substantial oxidative stress and inflammation, which contribute to lung tissue damage and impaired immune function. Main body Variations in oxidative metabolism contribute to the inflammatory cascade which triggers pneumonia to commence and evolve, whereas oxidative stress as well as inflammatory processes is strongly related. Understanding the underlying immunological dysregulation and unbalanced redox that heighten vulnerability to a variety of illnesses has improved over the past several decades attributable to research. One of the key strategies for addressing oxidative stress is to lower the reactive oxygen species creation in the mitochondrion which is one of the main sites of their generation by using antioxidants, where they prevent oxidants from transferring electrons to other molecules. Consequently, antioxidants either directly or indirectly reduce the risk of damage and preserve the redox equilibrium. Therefore, antioxidants, due to their ability to neutralize reactive oxygen species and modulate inflammatory processes, have been explored as potential adjuvant therapies to enhance the treatment outcomes of community-acquired pneumonia. Where recent research has explored the potential of antioxidants as adjuvant therapy in the treatment of community-acquired pneumonia, aiming to mitigate these detrimental effects. Antioxidants such as N-acetylcystein, vitamin C, vitamin E, astaxanthin, and zinc have shown promising results in both preclinical and clinical studies. Conclusion Outcomes of several in vitro as well as in vivo antioxidant studies have demonstrated the antioxidants' promising potential as an adjunct pneumonia therapy. For an assessment of its effectiveness in this therapeutic context, more research involving humans will be required.

show abstract

Clinical characteristics and outcomes of patients with severe acute respiratory infections (SARI): results from the Egyptian surveillance study 2010–2014

Cited by 3 publications

References 1 publication

Human coronavirus OC43 and other respiratory viruses from acute respiratory infections of Egyptian children

Human coronavirus OC43 and other respiratory viruses from acute respiratory infections of Egyptian children

Multicenter study to describe viral etiologies, clinical profiles, and outcomes of hospitalized children with severe acute respiratory infections, Egypt 2022

Antioxidants as adjuvant therapy in the treatment of community-acquired pneumonia

Contact Info

Product

Resources

About