Clinical Characteristics and Predictors of In-Hospital Mortality among Older Patients with Acute Heart Failure

Matteis, Giuseppe De; Covino, Marcello; Burzo, Maria Livia; Polla, Davide Antonio Della; Franceschi, Francesco; Mebazaa, Alexandre; Gambassi, Giovanni

doi:10.3390/jcm11020439

Cited by 9 publications

(3 citation statements)

References 40 publications

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“…In-hospital mortality rates for acute heart failure range from 4% to 13%, and the mortality rate within one year after discharge is approximately 25% to 30%. Additionally, there is a significant readmission rate, with over 45% of patients requiring readmission following their initial discharge [6][7].…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Istaroxime in Patients With Acute Heart Failure: A Meta-Analysis of Randomized Controlled Trials

Khan¹,

Rawat²,

Khan³

et al. 2023

Cureus

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The aim of this study was to assess the efficacy and safety of istaroxime in patients with heart failure. Following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines, a search was conducted on the EMBASE and Medline databases to identify articles related to the safety and efficacy of istaroxime in patients with heart failure. The search covered the period from inception to May 31st, 2023, without any restrictions on the year of publication. The search strategy utilized relevant terms such as "istaroxime," "heart failure", "efficacy," and other related terms, along with their corresponding Medical Subject Headings (MeSH) terms. The outcomes assessed in this meta-analysis included the change in left ventricular ejection fraction (LVEF), E to A ratio (a marker of left ventricle function), cardiac index in L/min/m2, systolic blood pressure (SBP) in mmHg, left ventricular end-systolic volume (LVESV) in ml, and left ventricular end-diastolic volume (LVDSV) in ml. For safety analysis, gastrointestinal events and cardiovascular events were assessed. A total of three randomized controlled trials (RCTs) were included in this meta-analysis encompassing 211 patients with heart failure. Pooled analysis showed that istaroxime was effective in increasing LVEF (MD: 1.

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Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Istaroxime in Patients With Acute Heart Failure: A Meta-Analysis of Randomized Controlled Trials

Khan¹,

Rawat²,

Khan³

et al. 2023

Cureus

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“…In our country, studies such as Escobar et al focused on hospitalized patients of internal medicine and showed in-hospital mortality at 9.5%; these percentages may significantly increase when a geriatric population is being considered—potentially as high as 11% mortality [ 7 ]. In Spain, hospital mortality during admissions for acute HF is variable and constitutes a major problem from the point of view of public health and cost efficiency, putting a strain on healthcare expenditures [ 1 , 2 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Model of Biomedical and Contextual Factors Predicting In-Hospital Mortality due to Heart Failure

García-Torrecillas

Lea-Pereira

Alonso-Morillejo

et al. 2023

JPM

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Background: Among the clinical predictors of a heart failure (HF) prognosis, different personal factors have been established in previous research, mainly age, gender, anemia, renal insufficiency and diabetes, as well as mediators (pulmonary embolism, hypertension, chronic obstructive pulmonary disease (COPD), arrhythmias and dyslipidemia). We do not know the role played by contextual and individual factors in the prediction of in-hospital mortality. Methods: The present study has added hospital and management factors (year, type of hospital, length of stay, number of diagnoses and procedures, and readmissions) in predicting exitus to establish a structural predictive model. The project was approved by the Ethics Committee of the province of Almeria. Results: A total of 529,606 subjects participated, through databases of the Spanish National Health System. A predictive model was constructed using correlation analysis (SPSS 24.0) and structural equation models (SEM) analysis (AMOS 20.0) that met the appropriate statistical values (chi-square, usually fit indices and the root-mean-square error approximation) which met the criteria of statistical significance. Individual factors, such as age, gender and chronic obstructive pulmonary disease, were found to positively predict mortality risk. Isolated contextual factors (hospitals with a greater number of beds, especially, and also the number of procedures performed, which negatively predicted the risk of death. Conclusions: It was, therefore, possible to introduce contextual variables to explain the behavior of mortality in patients with HF. The size or level of large hospital complexes, as well as procedural effort, are key contextual variables in estimating the risk of mortality in HF.

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“…The vast majority of young patients deny history of chest pain prior to MI. 1 Approximately one to two percent of the adult population in developed countries has Heart failure, with the prevalence of more than 10 percent among persons age less than or equal to seventy years of age. However, in younger individual it is also prevalent.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Leading to ST Elevation Myocardial Infarction in Young Patients Presenting to a Tertiary Care Hospital, Islamabad Pakistan

Nawaz¹,

Bibi²,

Shah³

et al. 2022

PJMHS

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Objective: To determine the risk factors leading to ST Elevation Myocardial infarction in young patients presenting to a tertiary care hospital,Islamabad Pakistan Methodology: Prospective observational study was conducted at Pakistan Institute of Medical Sciences, Cardiology department, Islamabad, Pakistan for duration of 10 months. Study was conducted on sample size of 164 selected through non-probability consecutive sampling technique. Study included participants with age less than or equals to 45 and participants from both genders.However, participants with Age more than 45and those having non ST myocardial infarction were excluded. findings including Blood pressure, pulse, respiratory rate, cyanosis, S3, Killip class and JVP were noted. Data was entered and analyzed using statistical package for social sciences (SPSS). P value of < 0.05 was considered as significant. Results: Mean age of participant was found to be 25.3±4.3, mean BMI was found to be 25.8 ±0.81. Mean HB level was found to be 12.8±0.8 and mean respiratory rate was found to be 18. Risk factor HTN in association with gender was found to have significant difference between two with p value of 0.01 In study analysis it was seen that risk factor HTN in association with age was found to have significant difference between two with p value of 0.05.Smoking in association with age was found to have shown significant difference between two with p value of 0.02Family history of MI in association with age was found to have shown significant difference between two with p value of 0.04. Conclusion: Risk factors HTN ,Smoking and family history were found to be positively associated with ST elevation myocardial infarctionin young age.

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Clinical Characteristics and Predictors of In-Hospital Mortality among Older Patients with Acute Heart Failure

Cited by 9 publications

References 40 publications

Safety and Efficacy of Istaroxime in Patients With Acute Heart Failure: A Meta-Analysis of Randomized Controlled Trials

Safety and Efficacy of Istaroxime in Patients With Acute Heart Failure: A Meta-Analysis of Randomized Controlled Trials

Structural Model of Biomedical and Contextual Factors Predicting In-Hospital Mortality due to Heart Failure

Risk Factors Leading to ST Elevation Myocardial Infarction in Young Patients Presenting to a Tertiary Care Hospital, Islamabad Pakistan

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