Clinical characteristics and prognosis of pulmonary inflammatory myofibroblastic tumor: An over 10‐year retrospective analysis

Zhang, Na; Zeng, Qi; Chen, Chenghao; Yu, Jie; Yan, Dong; Xu, Changcheng; Liu, Dingyi; Zhang, Qian; Zhang, Xu

doi:10.1002/ped4.12218

Cited by 16 publications

(19 citation statements)

References 18 publications

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“…For tumors with the maximum diameter of over 5 cm, more rounds of treatment and multiple ablation points are required for curative ablation. The treatment period for our patient was 6 months long and no distant metastasis occurred during the treatment, which was consistent with previous reports showing that IMT has of low degree of malignance and most patients have a good prognosis (27). For our patient, although the diameter of the tumor was over 5 cm, he was successfully treated with MWA monotherapy and has no evidence of recurrence nearly 3 years since the last treatment according to the follow-up chest enhancement CT images, laboratory examination, and clinical manifestations.…”

Section: Discussionsupporting

confidence: 91%

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Microwave ablation for the management of pulmonary inflammatory myofibroblastic tumor: a case report and literature review

Zhang¹,

Zheng²,

Meng³

et al. 2021

Transl Cancer Res TCR

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Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor. Although IMT generally exhibits benign biological behavior, some IMT patients may develop local recurrence or even distant metastasis. Surgery is the most common therapeutic approach. However, additional treatment options are necessary for those who are unable to undergo surgical treatments. Microwave ablation (MWA) is a developing treatment option for unresectable lung cancer. Compared with radiofrequency ablation (RFA), MWA possesses many advantages including larger ablation zones, shorter heating times, and less susceptibility to heat sink. Herein, we reported the case of an 80-year-old male patient who presented with a mass in the right lower pulmonary lobe and right pleural effusion. The maximum diameter of the mass was 53.76 mm, and the patient's main complaint was fatigue for 2 months. Blood test showed severe anemia (hemoglobin: 79 g/L) and hypoproteinemia (albumin: 27.7 g/L). After undergoing blood transfusion, supplementation of albumin, thoracical puncturing and piping, the patient's nutritional condition was improved (hemoglobin, 95 g/L; serum albumin, 29.9 g/L). The pathological diagnosis was pulmonary IMT by percutaneous lung biopsy. The patient was successfully treated with three rounds of percutaneous MWA and has no evidence of recurrence nearly 3 years later. This case has expanded the therapeutic options for elderly patients with pulmonary IMT. Percutaneous MWA monotherapy might serve as an emerging treatment strategy for medically inoperable patients.

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Section: Discussionsupporting

confidence: 91%

“…Previously, conventional surgery (thoracotomy or video-assisted thoracoscopic surgery) was the main therapeutic strategy for pulmonary IMT ( 5 , 6 , 26 , 27 ). Complete resection probably results in cure ( 7 , 8 ).…”

Section: Discussionmentioning

confidence: 99%

Microwave ablation for the management of pulmonary inflammatory myofibroblastic tumor: a case report and literature review

Zhang¹,

Zheng²,

Meng³

et al. 2021

Transl Cancer Res TCR

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“…Characterized by its rare local recurrence and metastasis, IMT is considered moderately malignant and has favorable prognosis (17)(18)(19). In the initial surgery, complete excision of tumors with clear surgical margins can prevent recurrence (9).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumors in Children: A Clinical Retrospective Study on 19 Cases

Qian

et al. 2021

Front. Pediatr.

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Background: Inflammatory myofibroblastic tumor (IMFT) is a rare neoplasm mainly affecting children and young adults. We conducted a retrospective study to evaluate the clinical features and treatment alternatives of childhood inflammatory myofibroblastic tumors.Methods: A total of 19 patients who were pathologically diagnosed with IMT between December 2008 and October 2018 were included. Collected data were demographic information, main complaints, tumor characteristics, treatment, pathological results, immunohistochemical analysis, and prognosis.Results: The male/female ratio was 13:6. The mean age at disease onset was 44.9 ± 33.9 months (range 4 to 111 months). The mean tumor size was 6.5 ± 4.0 cm (range 1.2 to 17.0 cm). The most common site was the abdomen (13/19). The most commonly used detection tool was CT. Eleven patients (57.9%) had aggressive tumor growth, including eight receiving extensive resection and three receiving palliative resection due to high local invasiveness and postoperative chemotherapy. Eight cases whose tumors were completely enveloped received complete resection. Immunohistochemistry was performed for 17 patients and ALK positivity was found in 11 patients. Despite three children lost to follow-up, sixteen patients were followed up for 6 to 132 months (average 63.9 months, median 66 months). Of which, twelve children survived with no evidence of IMT, and four cases (21%) showed local recurrences (two of them died). No distant metastasis was detected.Conclusions: IMT is rare in children with various locations, mostly appearing in the abdomen. Whether the tumor could be completely removed, the location and the invasiveness of surrounding tissues might be highly prognosis-related.

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“…IMT is a mesenchymal neoplasm, first described by B ahadori and L iebow [ 4 ] in 1973, that accounts for 0.04–1% of all lung neoplasms [ 5 ]. The tumour presents with intermediate biological potential, occurring at any anatomic site, with a predilection for the lung, soft tissue and viscera of children and young adults below 40 years old, in both genders [ 3 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual diagnosis in a patient presenting with fever and bilateral lung infiltrates

Petta¹,

Zetos²,

Bisirtzoglou³

et al. 2021

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Clinical characteristics and prognosis of pulmonary inflammatory myofibroblastic tumor: An over 10‐year retrospective analysis

Abstract: Beijing Hospital Administration pediatric discipline collaborative development center pediatrics special project (XTZD20180105)

Cited by 16 publications

References 18 publications

Microwave ablation for the management of pulmonary inflammatory myofibroblastic tumor: a case report and literature review

Microwave ablation for the management of pulmonary inflammatory myofibroblastic tumor: a case report and literature review

Inflammatory Myofibroblastic Tumors in Children: A Clinical Retrospective Study on 19 Cases

Unusual diagnosis in a patient presenting with fever and bilateral lung infiltrates

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