Clinical characteristics and prognostic factors of pulmonary MALT lymphoma

Borie, Raphaël; Wislez, Marie; Thabut, Gabriel; Antoine, Martine; Rabbat, Antoine; Lj, Couderc; Monnet, I.; Nunès, Hilario; Blanc, François-Xavier; Mal, H.; Bergeron, Anne; Dusser, Daniel; Israël‐Biet, Dominique; Crestani, Bruno; Cadranel, Jacquès

doi:10.1183/09031936.00039309

Cited by 178 publications

(211 citation statements)

References 38 publications

Supporting

Mentioning

195

Contrasting

Unclassified

Order By: Relevance

“…It occurs between the ages of 50 and 80 years, with male predominance; our patient was a 52-year-old male. In the largest clinical series, which included 63 patients with primary pulmonary extranodal MZL, the median age was 60 years and 36% of cases were asymptomatic at time of diagnosis (10). If the patient has symptoms, such as cough, chest pain, or dyspnea, early diagnosis may be possible.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Extranodal Marginal Zone Lymphoma: An Atypical Radiological Pattern

Kabalak¹,

Öz²,

Kankaya³

et al. 2017

Respir Case Rep

View full text Add to dashboard Cite

Primary pulmonary extranodal marginal zone lymphoma (PPEMZL) arising from the mucosa-associated lymphoid tissue of the bronchus is a very rare disorder. It appears in the form of a slowly progressing localized mass or consolidation. Clinical presentation may include non-specific pulmonary symptoms, such as chronic cough, or dyspnea, but it is more often diagnosed incidentally. Computed tomography (CT) the thorax revealed that the present patient had a giant cystic lesion, parenchymal nodules, and consolidation area. The patient was symptomatic and diagnosed as marginal zone lymphoma by immunohistochemical study of the transthoracic biopsy specimen. This patient is thought to be the first diagnosed as PPEMZL from a cystic lesion.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Extranodal Marginal Zone Lymphoma: An Atypical Radiological Pattern

Kabalak¹,

Öz²,

Kankaya³

et al. 2017

Respir Case Rep

View full text Add to dashboard Cite

show abstract

“…Primary pulmonary lymphomas About half of the patients with primary pulmonary MALT lymphoma are asymptomatic at presentation, and nearly half of these cases are identified accidentally on the basis of abnormal radiological findings [41]. The pulmonary symptoms are nonspecific, like cough, dyspnoea, chest pain and occasional haemoptysis, but are more common than constitutional symptoms, such as weight loss, fever, night sweats or fatigue.…”

Section: Specific Entitiesmentioning

confidence: 99%

Lymphoproliferative lung disorders: clinicopathological aspects

Poletti¹,

Ravaglia²,

Tomassetti³

et al. 2013

Eur Respir Rev

View full text Add to dashboard Cite

Lymphoproliferative disorders are rarely observed as primary lesions in the lung, representing only 0.3% of all primary pulmonary malignancies, ,1% of all the cases of non-Hodgkin lymphoma and 3-4% of all the extra nodal manifestations of non-Hodgkin lymphoma. The earliest comprehensive studies of pulmonary lymphomas were those of SALTZSTEIN [1] and PAPIOANNOU and WATSON [2], which were published in the 1960s. These investigators made important observations: low-grade neoplasms were more frequent than higher grade lymphomas (reticulum cell sarcomas) and both tumours had better clinical outcomes than their nodal-based counterparts. The authors also concluded that the majority of neoplasms with a low-grade cytological appearance should be considered as reactive proliferations, introducing the term ''pseudolymphoma''. This hypothesis showed significant weak points and, approximately 20 years later, ADDIS et al. [3] concluded that ''most if not all the cases of pseudo-lymphoma can be classified, when re-evaluated, as malignant lymphoma''. Knowledge of these entities expanded rapidly after the advent of new investigative tools such as immunohistochemistry and molecular biology techniques. The World Health Organization (WHO) classification of lymphoid neoplasm recently emphasised the importance of clinical features [4]. Table 1 provides an overall classification of lymphoproliferative disorders, which are described as: reactive/nonneoplastic lymphoid lesions, malignant parenchymal lymphoproliferative lesions (primary or secondary) and post-transplant lymphoproliferative disorders. Pathological aspectsReactive pulmonary lymphoid diseases Three rare forms of benign hyperplasia of pulmonary lymphoid tissue, namely follicular bronchiolitis, pulmonary nodular lymphoid hyperplasia and lymphocytic interstitial pneumonia, are regarded as part of the spectrum of lymphoid hyperplasia of the bronchus-associated lymphoid tissue (table 1) [5,6]. Follicular bronchiolitis is characterised by lymphoid follicular hyperplasia, often with reactive germinal centres, in the walls of bronchioles with narrowing of the lumen. Pulmonary nodular lymphoid hyperplasia (pulmonary pseudo-lymphoma) is a distinct form of reactive lymphoid proliferation with links to the family of IgG4-related sclerosing diseases, characterised by a dense nodular infiltration of mature, polyclonal lymphocytes and plasma cells, which are well-circumscribed and mainly sub-pleural, with some dense fibrosis between

show abstract

“…(7) A study published in 2009 demonstrated the presence of autoimmune disease in 10 of 63 cases of pulmonary MALT lymphoma analyzed. (8) The association between HIV infection and pulmonary MALT lymphoma is unclear, few cases having been reported. (4) The diagnosis is usually difficult and timeconsuming because most individuals are asymptomatic, being diagnosed on the basis of incidental findings on chest X-rays.…”

mentioning

confidence: 99%

“…A recent study reported a five-year survival rate of 90% and a ten-year survival rate of 72%. (8) The most effective treatment has yet to be defined. Various therapeutic regimens have been proposed, including radiotherapy, surgery, chemotherapy, and clinical observation.…”

mentioning

confidence: 99%

“…(6) It has been estimated that the risk of developing a lymphoma, especially a marginal zone lymphoma, is higher in patients with Sjögren's syndrome than in the general Rio de Janeiro -Rio de Janeiro, Brazil disseminated disease. (8) The approach to the case reported here was close observation, a decision that was based on the fact that the patient was clinically stable and was HIV-positive. As previously stated, pulmonary MALT lymphoma is a rare disease, although it is the most common form of primary pulmonary lymphoma.…”

mentioning

confidence: 99%

See 1 more Smart Citation