Clinical Characteristics and Prognostic Factors in Bone Metastases from Lung Cancer

Zhang, Li; Gong, Zhe-Xuan

doi:10.12659/msm.902971

Cited by 97 publications

(94 citation statements)

References 22 publications

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“…Therefore, ALP has been extensively used to screen patients for bone metastasis. Some studies have shown that the baseline ALP level and changes in the ALP level can predict treatment effects and survival in bony metastatic cancers . After analyzing 168 lung cancer patients, Zhang et al .…”

Section: Discussionmentioning

confidence: 99%

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The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non‐small cell lung cancer after surgery

Zhang

Yue

et al. 2019

Thoracic Cancer

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Background To assess the potential prognostic value of the albumin to alkaline phosphatase ratio (AAPR) in patients with non‐small cell lung cancer (NSCLC) after surgery. Methods The log‐rank and Kaplan‐Meier analyses were performed to detect differences in survival levels between different groups. A model of Cox proportional hazards was used to perform univariate and multivariate survival analyses. Comparisons of receiver operating characteristic (ROC) curves and the likelihood ratio test (LRT) were also utilized to compare the prognostic abilities of different systems for overall survival (OS) prediction. Results The optimal cut‐off value of the preoperative AAPR was 0.64. A decreased AAPR was associated with several clinicopathological and clinicolaboratory variables related to cancer progression. The preoperative AAPR of patients was positively correlated with the poor prognosis of NSCLC. In multivariate analyses, the preoperative AAPR was identified as an independent prognostic factor for disease‐free survival (DFS; P = 0.001) and overall survival (OS; P = 0.003). The LRT showed that the AAPR tumor‐node‐metastasis (TNM) system presented a significantly larger χ2 value (112.4 vs. 89.2, respectively, P < 0.01) and a relatively smaller Akaike information criterion (AIC) value (2955 vs. 2977, respectively, P < 0.01) than the TNM staging system. Conclusion Preoperative AAPR was a potentially valuable prognostic factor in NSCLC patients who underwent surgery. Our results further showed that the AAPR‐TNM system was superior to the current TNM staging system.

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Section: Discussionmentioning

confidence: 99%

“…After analyzing 168 lung cancer patients, Zhang et al . reported that the serum ALP level is a prognostic factor for bone metastases in lung cancer and that a higher serum ALP level is associated with shorter survival …”

Section: Discussionmentioning

confidence: 99%

The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non‐small cell lung cancer after surgery

Zhang

Yue

et al. 2019

Thoracic Cancer

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“…Lung cancer is the leading cause of cancer-related deaths worldwide, with 50-70% of patients suffering from bone metastasis [1][2][3][4][5] . Detrimental skeletal-related events are more common in end-stage patients and are associated with significant morbidity [6][7][8] .…”

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confidence: 99%

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Zou

Zhu

Lian

et al. 2019

Sci Rep

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Lung cancer is the leading cause of cancer-related deaths worldwide, with 50-70% of patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion in malignancy, such as lung cancer bone metastasis. In the present study, we demonstrated that reduced miR-192-5p and increased TRIM44 levels were associated with the proliferation, migration and invasion of lung cancer. Furthermore, the potential functions of miR-192-5p were explored in A549 and NCI-H1299 cells. We found that miR-192-5p upregulation suppressed tumour behaviours in lung cancer cells. To further investigate whether miR-192-5p is associated with TRIM44, we used TargetScan software to predict the binding site between miR-192-5p and TRIM44. Luciferase activity assays were performed to verify this prediction. In addition, the significant role of miR-192-5p in negatively regulating TRIM44 expression was manifested by our research group. our results suggest that miR-192-5p inhibited the proliferation, migration and invasion of lung cancer through TRIM44.

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“…24,25 It is commonly recognized to have high diagnosis specificity in bone metastasis and has been reported in certain bony metastasis malignancies. [26][27][28] Additionally, ALP was found to influence inflammation through regulation of purinergic signaling and induce an inhibitory immune response. 29 Besides, ALP can be generated and released into the blood directly by tumor cells and regulates tumor growth.…”

Section: Discussionmentioning

confidence: 99%

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

Zhang¹,

Yong²,

Ji³

et al. 2019

OTT

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Background: Pretreatment albumin/alkaline phosphatase ratio (AAPR) has been discussed about its prognostic value in several malignancies, whereas its role in cervical cancer remains unclear. In this study, we attempt to explore the prognostic significance of the AAPR in stage IB-IIA cervical cancer patients who underwent a radical hysterectomy. Patients and methods: A total of 230 cervical cancer patients were enrolled in this retrospective study. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis and multivariate analysis were performed to identify independent prognostic predictors of disease-free survival (DFS) and overall survival (OS). Results: The optimal cutoff value of the preoperative AAPR was 0.68. Patients with AAPR<0.68 showed obviously inferior OS and DFS than those with AAPR>0.68 according to Kaplan-Meier curves (DFS: P = 0.011; OS: P = 0.017). In multivariate analysis, the preoperative AAPR showed to be an independent predictive factor for disease-free survival (DFS: P = 0.015) and overall survival (OS: P = 0.019). Moreover, subgroup analysis revealed that the lower AAPR was correlated with worse prognosis in patients with histologic grade I-II; but in those with histologic grade III, there was no significant difference between the two groups. Conclusion: Preoperative AAPR was a potentially valuable prognostic index in stage IB-IIA cervical cancer patients. Further prospective studies are required to validate its prognostic value.

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Clinical Characteristics and Prognostic Factors in Bone Metastases from Lung Cancer

Cited by 97 publications

References 22 publications

The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non‐small cell lung cancer after surgery

The prognostic value of the preoperative albumin to alkaline phosphatase ratio in patients with non‐small cell lung cancer after surgery

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

<p>The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer</p>

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