Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients &gt; 50 Years in Korea

Shi, Hye Jin; Nham, Eliel; Kim, Bomi; Joo, Eun-Jeong; Cheong, Hae Suk; Hong, Shin Hee; Hyun, Miri; Kim, Hyun ah; Jang, Shin Yi; Rhee, Ji-Young; Kim, Jung Ok; Kim, Eui Chong; Cho, Hyun Kyu; Wi, Yu Mi; Cheon, Shinhye; Kim, So Hyun; Lim, Seungjin; Seok, Hyeri; Jung, Sook-In; Eom, Joong Sik; Peck, Kyong Ran

doi:10.3346/jkms.2022.37.e175

Cited by 11 publications

(14 citation statements)

References 21 publications

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“…In addition, the ratio of direct deaths caused by COVID-19 tended to decrease in phase II, where most patients died due to severe comorbidities. This observation is equivalent to that reported in several official releases of epidemiological data and clinical reports (4,15,17,20,(22)(23)(24)(25)(26).…”

Section: Discussionsupporting

confidence: 86%

Age distribution and disease severity of COVID-19 patients continued to change in a time-dependent manner from May 2021 to April 2022 in the regional core hospital in Japan

Kawaura

Kishi

Yamamoto

et al. 2023

DD&T

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SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, coronavirus disease 2019, mortality, infectivityThe present retrospective study aimed to examine the real-world data regarding time-dependent changes in the age distribution of patients with coronavirus disease 2019 (COVID-19) as well as the severity and infectivity in a regional core hospital in Japan. Patients with COVID-19 who visited the fever outpatient branch in Takagi Hospital during phase I (May 1 to December 31, 2021), and during phase II (January 1 to April 30, 2022) were evaluated. The age distribution of outpatients and the characteristics of inpatients aged > 75 years were compared between phases I and II. The age distribution of outpatients shifted from the older generation in phase I to the younger generation in phase II (p < 0.01). Disease severity might be reduced in a time-dependent manner with a decrease in the hospitalization rate (phase I: 145/368 (39.4%); phase II: 104/1496 (7.0%); p < 0.01) and mortality rate (phase I: 10/368 (2.7%); phase II: 7/1496 (0.5%); p < 0.01). The number of patients increased in phase II (374.0/month) compared to that in phase I (36.8/month). Regarding the older inpatients, the disease severity of COVID-19 and hospitalization days were reduced in phase II compared to those in phase I (p < 0.01, each). In conclusion, the present study suggests a change in the age distribution of patients with COVID-19, a decrease in toxicity, and an increase in infectivity of severe acute respiratory syndrome coronavirus 2 in a time-dependent manner.

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Section: Discussionsupporting

confidence: 86%

Age distribution and disease severity of COVID-19 patients continued to change in a time-dependent manner from May 2021 to April 2022 in the regional core hospital in Japan

Kawaura

Kishi

Yamamoto

et al. 2023

DD&T

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“…In the present study, only 21.2% of the admitted patients and 24.39% of the deceased had comorbidities which were less than those reported in large cohorts studies carried out in other countries such as Austria ( 13 ), Denmark (11)and Germany ( 14 ). Also, we found no differences in age nor in frequency of comorbidity between the discharged and deceased patients.…”

Section: Discussioncontrasting

confidence: 84%

Demographic and clinical characteristics and outcomes of COVID-19 patients admitted to a university hospital in the west of Iran: a retrospective study in the third wave

Jesmani¹,

Bozorgomid²,

Shadmani³

et al. 2023

Vacunas

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“…Moreover, in more than 9000 medical cases with Omicron VG in Ontario, a significant decrease in the risk of death was observed in Omicron cases compared with Delta cases, and that higher risk of death was associated with Delta surges 62 . It has also been reported in the United Kingdom that Omicron led to milder disease than the Delta variant, with a shorter period of illness and fewer hospitalizations among vaccinated individuals, 63 in addition to that younger people infected with Delta (VG) even though fully vaccinated were not at risk of death 64 . Present results are also in line with another finding from South Africa and England, since they all have demonstrated substantial decreases in risk associated with Omicron 65,66 …”

Section: Discussionmentioning

confidence: 77%

Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants

Ali

Rashid

Ali

et al. 2023

Eur J Clin Investigation

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BackgroundThe pandemic of coronavirus disease 2019 (COVID‐19) has a broad spectrum of clinical manifestations. The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) undergoes continuous evolution, resulting in the emergence of several variants. Each variant has a different severity and mortality rate.Materials and MethodsIn this study, 1174 COVID‐19 patients were studied for mortality and severity over three SARS‐CoV‐2 predominating variant periods in 2021 and 2022 in Sulaimani Province, Iraq. In each period, a representative, variant virus was subjected to phylogenetic and molecular and clinical analysis.ResultsPhylogenetic analysis revealed three SARS‐CoV‐2 variants, belonging to: Delta B.1.617.2, Omicron BA.1.17.2, and Omicron BA.5.6. The Delta variants showed more severe symptoms and a lower PCR‐Ct value than Omicron variants regardless of gender, and only 4.3% of the cases were asymptomatic. The mortality rate was lower with Omicron (.5% for BA.5.2 and 1.3% for BA.1.17.2) compared with Delta variants (2.5%). The higher mortality rate with Delta variants was in males (2.84%), while that with Omicron BA1.17.2 and BA.5.2 was in females, 1.05% and .0%, respectively. Age group (≥70) years had the highest mortality rate; however, it was (.0%) in the age group (30–49) years with Omicron variants, compared with (.96%) in Delta variants.ConclusionsThere has been a surge in COVID‐19 infection in the city due to the predominant lineages of SARS‐CoV‐2, B.1.617, Omicron BA.1.17.2 and Omicron BA.5.6, respectively. A higher PCR‐Ct value and severity of the Delta variant over Omicron BA.1.17.2 and/or BA.5.2 variants were significantly correlated with a higher death rate in the same order.

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Clinical Characteristics and Risk Factors for Mortality in Critical Coronavirus Disease 2019 Patients 50 Years of Age or Younger During the Delta Wave: Comparison With Patients > 50 Years in Korea

Cited by 11 publications

References 21 publications

Age distribution and disease severity of COVID-19 patients continued to change in a time-dependent manner from May 2021 to April 2022 in the regional core hospital in Japan

Age distribution and disease severity of COVID-19 patients continued to change in a time-dependent manner from May 2021 to April 2022 in the regional core hospital in Japan

Demographic and clinical characteristics and outcomes of COVID-19 patients admitted to a university hospital in the west of Iran: a retrospective study in the third wave

Clinical outcomes and phylogenetic analysis in reflection with three predominant clades of SARS‐CoV‐2 variants

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