Clinical Characteristics and Risk Factors of Recurrent Mooren’s Ulcer

Abstract

Purpose To investigate the clinical characteristics of Mooren's ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren's ulcer. Methods We reviewed the medical records of 95 patients (100 eyes) diagnosed with Mooren's ulcer from May 2005 to December 2014. The patients were classified into recurrent and nonrecurrent groups and followed up for 18 months. The difference between two groups was estimated. The patients in the recurrent group were subdivided according to the history of corneal infection and corneal perforation, respectively. The recurrent time in the subgroups was analyzed. Results Patients in the recurrent group were more likely to have a history of corneal infection and corneal perforation than that in the nonrecurrent groups. In patients with recurrent Mooren's ulcer, the median time to first recurrence was 130 days in the infection group, 480 days in noninfection group, and 195 days in the perforation group versus 480 days in nonperforation group. Conclusion Corneal infection and corneal perforation were associated with early recurrence of Mooren's ulcer. The tailored follow-up schedule should be used for patients with corneal infection and corneal perforation due to the high risk of recurrence.

Treatment of Mooren’s ulcer coexisting with a pterygium using an intrastromal lenticule obtained from small-incision lenticule extraction: case report and literature review

“…The average age at onset is about 50 years. 10 Mooren's ulcer is thought to be an organ-specific autoimmune disease because a cornea-associated antigen is found in patients' corneal stroma. However, the etiopathogenesis remains unclear.…”

“…1,10 Previous research has indicated that the risk factors for Mooren's ulcer include corneal infection, trauma, and surgery. 10 The ulcerations can develop unilaterally or bilaterally with a pseudopterygium or at the donor site after pterygium surgery. 7 The coexistence of Mooren's ulcer and a pterygium is extremely rare; only two cases have been reported to date.…”

Mooren’s ulcer

“…Зажившие истонченные участки остаются помутневшими. Иногда зажившая роговица представлена только десцеметовой оболочкой со слоем задней стромы, покрытой эпителием [13]. Острота зрения может быть снижена за счет неправильного астигматизма, обусловленного рубцеванием периферической зоны.…”

Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren’s ulcer

“…Mooren’s ulcer (MU) is an inflammatory chronic ulcerative keratitis that initially affects the periphery of the cornea, and later progresses circumferentially and centrally, ultimately ending in perforation. 1,2 It can be either unilateral or bilateral (50%), and the scleras are typically preserved. 2 Clinically, it presents with intense pain, photophobia, and epiphora.…”

“…1,2 It can be either unilateral or bilateral (50%), and the scleras are typically preserved. 2 Clinically, it presents with intense pain, photophobia, and epiphora. Although the etiology and pathogenesis are usually multifactorial and remain unclear, organ-specific autoimmunity seems to be the most accepted theory.…”