Clinical characteristics and risk of second primary lung cancer after cervical cancer: A population-based study

Qian, Chengyuan; Liu, Hong; Yan, Feng; Meng, Shenglan; Wang, Dong; Nie, Min; Xu, Mingfang

doi:10.1371/journal.pone.0231807

Cited by 7 publications

(7 citation statements)

References 26 publications

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“…Lung metastasis was a unique common risk and prognostic factor. To uncover clinical-specific or common risk and prognostic factors for different metastatic sites among the cervical cancer population, we collected and compared clinical factors that were associated with cervical cancer with distant metastases, based on previous studies using the SEER database [ 5 , 6 , 8 , 9 , 11 ]. Late tumor stage was considered as a common potential risk factor for different metastatic sites.…”

Section: Resultsmentioning

confidence: 99%

“…Cervical cancer patients that presented both liver and lung metastases had a poor prognosis. It was not surprising that patients with multiple organ metastases had worse outcomes than single-site metastasis, which has been confirmed in many metastatic malignant tumors [ 6 , 11 ]. Considering that cervical cancer patients with different metastatic organs might benefit from individual treatment strategies [ 28 ], there are still scarce clinical risk and prognostic factors to predict the location and survival of different metastases.…”

Section: Discussionmentioning

confidence: 99%

“…The liver is a hematogenous metastatic site, following lung and bone, in cervical cancer patients [ 6 ]. Hepatic metastasis was also positively associated with worse overall survival [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study

Liu

et al. 2021

BMC Cancer

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Background Cervical cancer is one of the most frequent malignancies in women, particularly metastasis resulting in a poor prognosis. However, the clinical characteristics of cervical cancer patients with advanced liver metastasis have not been well investigated. We aimed to evaluate the incidence, clinical risk and prognostic factors for hepatic metastasis in cervical cancer patients. Materials and methods The clinical features of patients diagnosed with cervical cancer were collected from the Surveillance, Epidemiology and End Result (SEER) public cancer database between 2010 and 2015. Multivariate logistic and Cox regression models were performed to identify potential risk and prognostic factors for liver metastasis in patients with cervical cancer. Results A total of 431 patients (2.32%) developed liver metastasis in our analysis. The following characteristics were significantly associated with the development of liver metastasis: black ethnicity, uninsured status, higher tumor stage, poorer differentiated grade, non-squamous histology, non-surgery of primary site, patients with any additional lung, bone, and brain metastasis. Multivariate Cox regression showed that patients with additional lung metastasis, without radiotherapy, and without chemotherapy were negatively correlated with overall survival. Concurrent chemotherapy and radiotherapy was a favorable prognostic factor to improve overall survival, and chemotherapy showed to increase cause-specific survival. Additional lung metastasis was an independent characteristic for both risk and prognostic factors for hepatic metastasis in patients with cervical cancer. Conclusion Our results found several potential clinical features that may be used to assess the risk and prognosis of liver metastasis in patients with cervical cancer. These associated factors may provide clinical indications for the early identification and treatment of cervical cancer patients with hepatic metastasis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study

Liu

et al. 2021

BMC Cancer

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“…Better survival outcomes in patients diagnosed with cervical cancer have been reported due to advancements in the detection and treatment of the disease. However, with the growing number of cervical cancer survivors, primary second cancers in these patients pose a new challenge [ 10 ]. Compared to the general population, there is an increased incidence of a second primary malignancy in patients diagnosed and treated for cervical cancer [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Second Malignancies Following Primary Cervical Cancer Diagnosis: Analysis of the SEER Database

Akinyemi¹,

Abodunrin²,

Andine³

et al. 2022

Cureus

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IntroductionWhile mortality following primary cervical cancers (PCCs) continues to decline due to advancements in screening and treatment, a small subset of women who developed PCCs will develop second malignancies after their initial diagnosis. Little is known about these women. ObjectiveThis study aims to determine the common second malignancies among patients with primary cervical cancers and the factors associated with improved overall survival. MethodologyWe conducted a retrospective analysis of all PCCs in the SEER database between 1975 and 2016. We identified a subset of patients who subsequently developed secondary malignancies after a primary cervical cancer diagnosis. We then determined the factors associated with a prolonged latency interval, defined as the time between the PCC diagnosis and a subsequent secondary malignancy diagnosis. In a sub-analysis, we also determined the commonest secondary malignancies following a PCC diagnosis. ResultsA total of 1,494 patients with cervical cancers developed a second malignancy during the study period. The mean age at diagnosis of the PCCs was 56.0 ± 14.0 years. The mean latency interval between PCC and a subsequent secondary malignancy was 9.6 ± 9.3 years. Cytoreductive surgery (odds ratio (OR) = 1.40; 95% confidence interval (CI) = 1.05-1.86) and radiotherapy (OR = 1.52; 95% CI = 1.14-2.03) during the PCC are associated with a prolonged latency interval.Patients who received chemotherapy (OR = 0.23; 95% CI = 0.16-0.33) or those of Hispanic ethnicity (OR = 0.63; 95% CI = 0.44-0.90) were more likely to develop second malignancies within 10 years after a PCC diagnosis. The most common second malignancies were abdominal malignancies with rectal cancers (12.2%), pancreatic cancers (10.1%), stomach cancers (9.2%), cecum cancers (8.4%), and sigmoid colon cancers (8.3%). ConclusionThere is a significant association between Hispanic ethnicity and a shorter latency interval among patients with PCC. The findings from this study may help optimize screening for secondary cancers among cervical cancer survivors.

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“…Cervical cancer metastasis occurs mainly via the lymphatic route ( 10 ). The most common sites of distant metastases are the lungs, bones, and liver, in order of priority ( 11 ). It is rare for cervical cancer to spread to the central nervous system, and very little research has been conducted on this subject ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Cervical Cancer Imaging Features Associated With ADRB1 as a Risk Factor for Cerebral Neurovascular Metastases

Zheng

Xu²,

Wu³

2022

Front. Neurol.

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Bioinformatics tools are used to create a clinical prediction model for cervical cancer metastasis and to investigate the neurovascular-related genes that are involved in brain metastasis of cervical cancer. One hundred eighteen patients with cervical cancer were divided into two groups based on the presence or absence of metastases, and the clinical data and imaging findings of the two groups were compared retrospectively. The nomogram-based model was successfully constructed by taking into account four clinical characteristics (age, stage, N, and T) as well as one imaging characteristic (original_glszm_GrayLevelVariance Rad-score). In patients with cervical cancer, headaches and vomiting were more often reported in the brain metastasis group than in the other metastasis groups. According to the TCGA data, mRNA differential gene expression analysis of patients with cervical cancer revealed an increase in the expression of neurovascular-related gene Adrenoceptor Beta 1 (ADRB1) in the brain metastasis group. An analysis of the correlation between imaging features and ADRB1 expression revealed that ADRB1 expression was significantly higher in the low Rad-score group compared with the high Rad-score group (P = 0.025). Therefore, ADRB1 expression in cervical cancer was correlated with imaging features and was associated as a risk factor for cerebral neurovascular metastases. This study developed a nomogram prediction model for cervical cancer metastasis using age, stage, N, T and original_glszm_GrayLevelVariance. As a risk factor associated with the development of cerebral neurovascular metastases of cervical cancer, ADRB1 expression was significantly higher in brain metastases from cervical cancer.

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Clinical characteristics and risk of second primary lung cancer after cervical cancer: A population-based study

Cited by 7 publications

References 26 publications

Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study

Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study

Second Malignancies Following Primary Cervical Cancer Diagnosis: Analysis of the SEER Database

Cervical Cancer Imaging Features Associated With ADRB1 as a Risk Factor for Cerebral Neurovascular Metastases

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