Clinical characteristics and survival of children with hepatoblastoma: Single centre experience

Krstovski, Nada; Janić, Dragana; Dokmanović, Lidija; Smoljanic, Zeljko; Vukanic, Dragan

doi:10.2298/sarh0812603k

Cited by 1 publication

(1 citation statement)

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“…To further explore the two surgical therapies, their combination with chemotherapy contributed significantly to the improvement of survival (44). Preoperative chemotherapy can help more children be suitable for hepatectomy (4,37,45), and postoperative chemotherapy can dramatically improve the survival rate, whether for hepatectomy or liver transplantation (32,33). Although the results and some other studies suggested whether receiving chemotherapy before or after surgery did not show significant influence on prognosis (46,47), the reason could not be attributed to chemotherapy hastily, and routine chemotherapy should be conducted according to treatment guidelines (48,49).…”

Section: Discussionmentioning

confidence: 99%

A single-center retrospective analysis of childhood hepatoblastoma in China

Xiang

et al. 2020

Gland Surg

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Background: This study aimed to investigate the critical factors associated with prognosis for children with hepatoblastoma (HB) in mainland China combined with the aspect of health economics and management.Methods: This study retrospectively reviewed children with HB in Renji Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine from January 2013 to December 2019. Descriptive analysis was used to describe the essential characteristics. Kaplan-Meier method and Cox proportional hazard models were used to estimate the survival rate and prognosis factors.Results: For the 87 children with HB, the average survival was 2,002.8 days (95% CI: 1,798.7-2,206.9 days), the 1-and 5-year survival rates were 87.7% and 78.9%, respectively. Undergoing surgery and sex were independent prognostic factors of childhood HB. Children with HB undergoing hepatectomy (HR: 0.039) or liver transplantation (HR: 0.142) had a better prognosis, while boys were associated with a poorer prognosis (HR: 3.614). The average medical expenses for childhood HB were 40,217.5±3,862.0 CNY and liver transplantation cost more than hepatectomy. Conclusions:The results had a comparable survival rate with other studies globally. Surgical therapy and sex are associated with the prognosis of children with HB. The economic burden of childhood HB deserves to be further explored.

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