Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea

Chung, Sung Pil; Park, Sang Un; Cheon, Jae Hee; Kim, Eun Ran; Byeon, Jeong Sik; Ye, Byong Duk; Keum, Bora; Shim, Ki Nam; Jung, Sung Ae; Kim, Jin Oh; Jeon, Seong Ran; Song, Hyun Joo; Moon, Jeong Seop; Chang, Dong Kyung

doi:10.1007/s10620-015-3595-y

Cited by 33 publications

(53 citation statements)

References 19 publications

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“…Systemic corticosteroids may help but most patients develop corticosteroid dependent (1). Chung et al (2) found a response rate of corticosteroid was approximately 25%. To be able to wean corticosteroid, we attempted to use azathioprine as a maintenance immunomodulator that is frequently used in IBD.…”

Section: Discussionmentioning

confidence: 97%

“…Cryptogenic multifocal ulcerous stenosing enteritis is a rare idiopathic cause of ulceration and stricture of small bowel, which can be presented with acute or chronic GI bleeding, symptoms of bowel obstruction, abdominal pain, anemia, hypoalbuminemia, and perforation (1)(2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the treatment for this condition is not well-established and the prognosis also remains uncertain. Some reports also noted poor prognosis with frequent recurrence (2). We herein report a girl who had a longstanding history of iron deficiency anemia (IDA) and later was noted to have protein-losing enteropathy.…”

Section: Introductionmentioning

confidence: 86%

See 2 more Smart Citations

A rare cause of multiple small bowel ulcers and strictures in a 10-year-old child

Kijmassuwan¹,

Tanpowpong²,

Molagool³

et al. 2018

Turk J Gastroenterol

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A rare cause of multiple small bowel ulcers and strictures in a 10-year-old child

Kijmassuwan¹,

Tanpowpong²,

Molagool³

et al. 2018

Turk J Gastroenterol

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show abstract

“…In this issue of Digestive Diseases and Sciences [1], Chung and colleagues from South Korea describe a multicenter case series of ''cryptogenic multifocal ulcerous stenosing enteritis'' or CMUSE, defined using modern endoscopic methods for small intestinal mucosal evaluation and followed up for an extended period. Through these observations, the authors provide novel information regarding the long-term natural history of CMUSE, a specific syndrome initially described more than a half-century ago largely, although not entirely, in the French literature [2][3][4][5][6].…”

Section: Background and Significancementioning

confidence: 99%

Small Intestinal Multifocal Stenosing Ulceration

Freeman

2015

Dig Dis Sci

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“…At present, CMUSE is diagnosed mainly based on clinical and macroscopic imaging features of the small intestine. However, CMUSE is frequently misdiagnosed as other ulcerative small bowel diseases, such as Crohn’s disease (CD) or nonsteroidal anti-inflammatory drugs (NSAIDs)-induced enteropathy, because of similar clinical symptoms and nonspecific laboratory findings[3,4]. …”

Section: Introductionmentioning

confidence: 99%

Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior

Hwang

Kim

et al. 2017

WJG

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AIMTo investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior.METHODSTwenty pathologically and clinically confirmed CMUSE patients (males:females = 8:12; mean age: 40.4 years) between March 2002 and August 2015 from seven academic centers in South Korea were retrospectively reviewed. We evaluated small bowel series (SBS; n = 25), computed tomography (CT) enterography (n = 21), magnetic resonance (MR) enterography (n = 2), and abdominopelvic CT (n = 18) images, focusing on enteric and perienteric manifestations. Any change in radiologic features during follow-up period was recorded. We evaluated clinical data including presenting symptoms, laboratory finding and presence of relapse from electronic medical records. Histopathologic findings were also evaluated.RESULTSThe main symptoms were abdominal pain (n = 12) and anemia (n = 10). All patients showed small bowel strictures (n = 52, mean: 2.6 per patient) on initial CT/MR, located in the ileum (n = 47) or jejunum (n = 5). Strictures showed short-length (mean: 10.44 mm) and circumferential bowel wall thickening (mean: 5.56 mm) with layered enhancement (n = 48) that were also noted on initial SBS (n = 36) with shallow ulcers (n = 10). Some ulcerative lesions or wall thickening progressed into strictures on follow-up SBS/CT, and some strictures revealed recurrent ulceration on follow-up SBS. There were no penetrating disease features like fistula or abscess and no gastrointestinal tract involvement except the small bowel. Nine patients experienced disease recurrence (median relapse-free period: 32 mo) even post-operatively. Histopathologic features of surgically resected specimens were characterized as multiple superficial ulcerations confined to mucosa or submucosa and multiple strictures.CONCLUSIONUnder characteristic radiologic findings with multiple short-segmental strictures and/or shallow ulcers of the small intestine, CMUSE should be considered when assessing patients with recurrent abdominal pain and anemia.

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Clinical Characteristics and Treatment Outcomes of Cryptogenic Multifocal Ulcerous Stenosing Enteritis in Korea

Abstract: CMUSE is difficult to diagnose and is an easily relapsing disease. Female patients might have a better prognosis than male patients in terms of the relapse-free time.

Cited by 33 publications

References 19 publications

A rare cause of multiple small bowel ulcers and strictures in a 10-year-old child

A rare cause of multiple small bowel ulcers and strictures in a 10-year-old child

Small Intestinal Multifocal Stenosing Ulceration

Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior

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