Clinical Characteristics, Associated Factors, and Predicting COVID-19 Mortality Risk: A Retrospective Study in Wuhan, China

Yu, Caizheng; Lei, Qing; Li, Wenkai; Wang, Xiong; Liu, Wei; Fan, Xionglin; Li, Wengang

doi:10.1016/j.amepre.2020.05.002

Cited by 134 publications

(163 citation statements)

References 35 publications

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“…This is an important finding that should prompt attention to the possibility for more severe disease or a prolonged hospital course should patients report fatigue on presentation. With regards to increased mortality, older age, male gender, and immunosuppressed patients were predictors - similar to what is known in the general population and for a variety of other illnesses ( 25 , 26 ).…”

Section: Discussionsupporting

confidence: 59%

“…Although myalgia is commonly associated with generalized inflammation and cytokine response, a meta-analysis showed that myalgia is not relate with severity or mortality ( 24 ). With regards of anosmia/ageusia, a systematic review that included 42 studies showed an inverse relation with severity and hospitalization, suggesting that anosmia/ageusia are more frequently associated with mild-to-moderate COVID-19 ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…Among patients with gastrointestinal symptoms, obesity and male gender were associated with a higher rate of ICU admission and need for mechanical ventilation. Studies, including one meta-analysis, have shown obesity and male gender are associated with more severe disease and poorer outcomes in general population ( 25 , 26 ). Fatigue was also an independent factor associated with more ICU admission among patients ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

“…Studies, including one meta-analysis, have shown obesity and male gender are associated with more severe disease and poorer outcomes in general population ( 25 , 26 ). Fatigue was also an independent factor associated with more ICU admission among patients ( 25 ). Our study demonstrated that fatigue was also associated with more severe disease (i.e., ICU admission).…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal Manifestations and Associated Health Outcomes of COVID-19: A Brazilian Experience From the Largest South American Public Hospital

Proença

McCarty

Sagae

et al. 2020

Clinics

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Gastrointestinal Manifestations and Associated Health Outcomes of COVID-19: A Brazilian Experience From the Largest South American Public Hospital

Proença

McCarty

Sagae

et al. 2020

Clinics

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“…Almost all studies are primarily focused on the description of the epidemiologic, clinical, biological, and radiological characteristics of patients with confirmed coronavirus disease (COVID-19). 1,2 However, only a few studies, mainly case reports, have addressed the importance of the follow-up of recovered patients. 3,4 To date, the clinical and virologic course of SARS-CoV-2 infection remains to be investigated.…”

mentioning

confidence: 99%

Predictive Factors for a New Positive Nasopharyngeal Swab Among Patients Recovered From COVID-19

Landi

Carfì

Benvenuto

et al. 2021

American Journal of Preventive Medicine

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on behalf of Gemelli Against COVID-19 Post-Acute Care Team Introduction: As an emerging infectious disease, the clinical and virologic course of COVID-19 requires better investigation. The aim of this study is to identify the potential risk factors associated with persistent positive nasopharyngeal swab real-time reverse transcription-polymerase chain reaction tests in a large sample of patients who recovered from COVID-19. Methods: After the acute phase of SARS-CoV-2 epidemic infection, the Fondazione Policlinico A. Gemelli IRCSS of Rome established a post-acute care service for patients discharged from the hospital and recovered from COVID-19. Between April 21 and May 21, 2020, a total of 137 individuals who officially recovered from COVID-19 were enrolled in this study. All patients were tested for the SARS-CoV-2 virus with nucleic acid RT-PCR tests. Analysis was conducted in June 2020. Results: Of the 131 patients who repeated the nasopharyngeal swab, 22 patients (16.7%) tested positive again. Some symptoms such as fatigue (51%), dyspnea (44%), and coughing (17%) were still present in a significant percentage of the patients, with no difference between patients with a negative test and those who tested positive. The likelihood of testing positive for SARS-CoV-2 infection was significantly higher among participants with persistent sore throat (prevalence ratio=6.50, 95% CI=1.38, 30.6) and symptoms of rhinitis (prevalence ratio=3.72, 95% CI=1.10, 12.5). Conclusions: This study is the first to provide a given rate of patients (16.7%) who test positive on RT-PCR test for SARS-CoV-2 nucleic acid after recovering from COVID-19. These findings suggest that a significant proportion of patients who have recovered from COVID-19 still could be potential carriers of the virus. In particular, if patients continue to have symptoms related to COVID-19, such as sore throat and rhinitis, it is reasonable to be cautious by avoiding close contact, wearing a face mask, and possibly repeating a nasopharyngeal swab.

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The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis

Luo

et al. 2020

Clinical Cardiology

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Backgroud The association between underlying comorbidities and cardiac injury and the prognosis in coronavirus disease 2019 (COVID‐19) patients was assessed in this study. Hypothesis The underlying comorbidities and cardiac injury may be associated with the prognosis in COVID‐19 patients. Methods A systematic search was conducted in PubMed, EMBASE, Web of science, and The Cochrane library from December 2019 to July 2020. The odds ratio (OR) and 95% confidence intervals (95% CI) were used to estimate the probability of comorbidities and cardiac injury in COVID‐19 patients with or without severe type, or in survivors vs nonsurvivors of COVID‐19 patients. Results A total of 124 studies were included in this analysis. A higher risk for severity was observed in COVID‐19 patients with comorbidities. The pooled result in patients with hypertension (OR 2.57, 95% CI: 2.12‐3.11), diabetes (OR 2.54, 95% CI: 1.89‐3.41), cardiovascular diseases (OR 3.86, 95% CI: 2.70‐5.52), chronic obstractive pulmonary disease (OR 2.71, 95% CI: 1.98‐3.70), chronic kidney disease (OR 2.20, 95% CI: 1.27‐3.80), and cancer (OR 2.42, 95% CI: 1.81‐3.22) respectively. All the comorbidities presented a higher risk of mortality. Moreover, the prevalence of acute cardiac injury is higher in severe group than in nonsevere group, and acute cardiac injury is associated with an increased risk for in‐hospital mortality. Conclusion Comorbidities and acute cardiac injury are closely associated with poor prognosis in COVID‐19 patients. It is necessary to continuously monitor related clinical indicators of organs injury and concern comorbidities in COVID‐19 patients.

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Clinical Characteristics, Associated Factors, and Predicting COVID-19 Mortality Risk: A Retrospective Study in Wuhan, China

Cited by 134 publications

References 35 publications

Gastrointestinal Manifestations and Associated Health Outcomes of COVID-19: A Brazilian Experience From the Largest South American Public Hospital

Gastrointestinal Manifestations and Associated Health Outcomes of COVID-19: A Brazilian Experience From the Largest South American Public Hospital

Predictive Factors for a New Positive Nasopharyngeal Swab Among Patients Recovered From COVID-19

The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis

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