Clinical characteristics associated with bone mineral density improvement after 1-year alendronate/vitamin d3 or calcitriol treatment

Liao, Er-Yuan; Zhang, Zhenlin; Xia, Weibo; Lin, Hua; Cheng, Qun; Wang, Li; Hao, Yongqiang; Chen, Decai; Tang, Hai; Peng, Yongde; Li, You; He, Li; Hu, Zhao-Heng; Song, Chunli; Wei, Fang; Wang, Jue; Zhang, Lei

doi:10.1097/md.0000000000011694

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…The efficacy of calcitriol and calcium/Vitamin-D (caltrate) in the treatment of osteoporosis has been confirmed by many studies. 6 , 7 , 13 Calcitriol is the most active drug among the metabolites of active Vitamin-D. In a Chinese randomized control study (RCT), Zhang ZL et al 14 showed that calcitriol can improve bone metabolism factor levels in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study

Li,

Lin,

Lin

et al. 2023

Pak J Med Sci

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Objective: To explore the efficacy of Danshen injection combined with calcitriol and calcium/Vitamin-D in the treatment of osteoporotic fractures. Methods: This was a case–control study. We retrospectively reviewed clinical data of 91 patients with osteoporotic fractures who received treatment in Rui’an People’s Hospital from February 2021 to July 2022. The data were divided into a control group with 44 records of patients who received treatment with calcitriol and calcium/Vitamin-D, and a study group with 47 patients who received Danshen injection combined with calcitriol and calcium/Vitamin-D. The control group individuals were coordinated with the patients in terms of their age and gender. Treatment effects, inflammatory response levels, and bone metabolic status levels were comparable between the two groups before and after the treatment. Results: The total efficacy of the treatment in the study group was better than that in the control group (P<0.05). After the treatment, levels of serum inflammatory factors in both groups decreased compared to those before the treatment, and the study group displayed lower levels than the control group (P<0.05). After the treatment, the bone metabolism status of both groups improved, and the improvement effect of the study group was better (P<0.05). The incidences of adverse reactions were similar in both groups (P>0.05). Conclusions: Danshen injection combined with calcitriol and calcium/Vitamin-D for the treatment of osteoporotic fractures can effectively reduce inflammation, regulate bone metabolism, and improve fracture treatment efficacy with a favorable safety profile. doi: https://doi.org/10.12669/pjms.40.3.8513 How to cite this: Li H, Lin D, Lin H, Liu M, Lu G. Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study. Pak J Med Sci. 2024;40(3):291-296. doi: https://doi.org/10.12669/pjms.40.3.8513 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study

Li,

Lin,

Lin

et al. 2023

Pak J Med Sci

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“…Tendo isso em visto, sabe-se que o cálcio e a vitamina D trabalham sinergicamente no osso. Em contrapartida, outros estudos indicam que ainda é controverso se a insuficiência de vitamina Dn com ou sem baixa ingestão de cálcio na dietan pode afetar adversamente a resposta da DMO em pacientes com osteoporose na pós-menopausa (LIAO, EY et al, 2018b).…”

Section: Discussionunclassified

A relação entre deficiência de vitamina D e osteoporose em mulheres na pós-menopausa

Morais

Ayres²,

Andrade³

et al. 2020

BJHR

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RESUMO INTRODUÇÃO: No período pós-menopausa ocorrem alterações hormonais que modificam a homeostase do organismo feminino, podem causar a redução da densidade óssea, com consequente osteoporose. METODOLOGIA: Trata-se de uma revisão narrativa, com busca de estudos nas bases de dados MEDLINE, SciELO e LILACS. Para pesquisa utilizou-se os descritores "vitamin d", "postmenopausal" e "osteoporosis". Foram incluídas publicações do anos de 2015 a 2020, nos idiomas português, inglês e espanhol, e disponibilização do texto completo. RESULTADOS: Os artigos analisados foram publicados em periódicos internacionais. Foram selecionados estudos de revisão, ensaios clínicos, estudos transversais, estudos retrospectivos, estudos prospectivos, estudos de coorte e metanálises. DISCUSSÃO: A osteoporose é considerada um problema de saúde pública, principalmente, devido ao envelhecimento da população. Associado a isso, a vitamina D ganhou destaque no cenário da saúde atual, uma vez que mulheres com osteoporose, geralmente, apresentam deficiência dessa vitamina. Tal condição merece atenção, uma vez que mulheres na pós-menopausa com osteoporose e com níveis insuficientes de vitamina D reduzem a fixação de cálcio nos ossos e o transporte de cálcio no retículo sarcoplasmático. CONCLUSÃO: A vitamina D, além do potencial efeito terapêutico em pacientes menopausadas, apresenta-se como forma de prevenção da osteoporose e suas consequências.

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“…Targeted therapy for bone metastasis aims to reduce or delay the occurrence of bone-associated events, including pathological fracture and bone pain, therefore improving the quality of life of patients and extending their survival time. Advances in the therapeutic options for the treatment of bone disease include the use of bisphosphonates (64), denosumab (65) or RANKL-antibodies that target osteoclastogenesis, which have significantly reduced the complications of bone metastasis and offered good clinical effects (66–68). However, the overall survival time of patients with bone metastases has not significantly improved with these treatments (69).…”

Section: Cancer To the Bone: A Fatal Attractionmentioning

confidence: 99%

Role of tumor‑derived exosomes in bone metastasis (Review)

Liu

et al. 2019

Oncol Lett

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Tight coupling between bone resorption and formation is essential for bone remodeling. Disruption of this equilibrium can lead to skeletal disorders. Osseous metastatic disease is a severe consequence of tumor cell dissemination from numerous primary cancer sites, including the prostate, lungs and breasts. Metastatic disease is one of the most common causes of mortality in patients with cancer. Rapid advances in the therapeutic options for bone disease, including the use of bisphosphonates, have achieved effective clinical effects. However, the overall survival time of patients with bone metastatic has not significantly improved. Exosomes, which originate from tumor tissue and preferentially the bone, provide a reasonable way to understand the mechanism of neoplastic bone metastasis. Recently, several studies have indicated that tumor-derived exosomes are involved in cancer progression. However, the potential role that exosomes serve in the pathological communication between tumor and bone cells within the skeletal microenvironment remains an emerging field. The present review reports some recent findings on the detrimental roles of exosomes in bone metastasis. In addition, since exosomes are involved in metabolic organ cross-talk, this review highlights the involvement of cancer-derived exosomes in the regulation of skeletal metastatic diseases. Lastly, the potential promising clinical applications and emerging therapeutic opportunities targeting exosomes are discussed as novel strategies for cancer therapy.

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Clinical characteristics associated with bone mineral density improvement after 1-year alendronate/vitamin d3 or calcitriol treatment

Abstract: Supplemental Digital Content is available in the text

Cited by 9 publications

References 41 publications

Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study

Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study

A relação entre deficiência de vitamina D e osteoporose em mulheres na pós-menopausa

Role of tumor‑derived exosomes in bone metastasis (Review)

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