Clinical Characteristics Associated with the Development of Cystoid Macular Edema in Patients with Cytomegalovirus Retinitis

Kwon, Hye Ji; Son, Gisung; Lee, Joo‐Yong; Kim, June-Gone; Kim, Yoon-Jeon

doi:10.3390/microorganisms9061114

Cited by 5 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cystoid macular oedema is one of the clinical manifestations of CMV retinitis [ 8 ]. CMV retinitis patients with cystoid macular oedema have poorer vision, longer virus duration, and poor prognosis [ 18 ]. Cystoid macular oedema usually develops before the injection of ganciclovir.…”

Section: Discussionmentioning

confidence: 99%

CMV retinitis and subsequent acute cystoid macular oedema after treatment with vitreous ganciclovir injection: a case report

Liu

Lü

et al. 2022

BMC Ophthalmol

View full text Add to dashboard Cite

Background To report a very rare acute cystoid macular oedema following ganciclovir injection in patients receiving allogeneic haematopoietic stem cell transplantation. Case presentation A 44-year-old male patient experienced vision loss in his left eye eight months after allogeneic stem cell transplantation. Ophthalmologic examination showed posterior retinopathy with retinal haemorrhage, a yellow necrotic border, and a vascular white sheath involved in the superior temporal retina but not the posterior pole. Cytomegalovirus DNA results in both plasma and ocular fluid were positive. All tests combined with the patient’s medical history suggested that his ocular disease was cytomegalovirus retinitis. Consequently, he received a weekly ganciclovir vitreous injection. The disease was visibly controlled, and the fundus condition improved after the first three treatments. However, the patient had severe vision loss in his left eye and acute cystic oedema in the macula, while the original lesion was stable two hours after the fourth treatment. The macular oedema subsided significantly on the first day. Over the next week, daily OCT findings indicated that the patient's macular oedema gradually subsided and resolved completely by the second week, and his left eye vision partially improved. Conclusion Macular oedema may occur in patients with cytomegalovirus retinitis, but it rarely occurs during treatment. In this case, the patient's macular oedema appeared and resolved quickly. Macular oedema in patients with cytomegalovirus retinitis receiving vitreous cavity injections of ganciclovir needs to be further studied and discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

CMV retinitis and subsequent acute cystoid macular oedema after treatment with vitreous ganciclovir injection: a case report

Liu

Lü

et al. 2022

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…After primary infection, CMV remains in the host cells in latent form. The risk of CMV recurrence is dependent on the level of incompetency of the immune system [35][36][37][38][39] , manifested as an impairment of T-cell immunity, including the presence and function of CMV-specific cytotoxic T lymphocytes. From the regression analysis, we found that the extent of fundus lesions, and the presence of vitreous haze were related to retinitis recurrence, among which the extent of fundus lesions has a significant association with the recurrence of CMVR.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China

Shi¹,

Kang²,

Feng³

et al. 2022

Int J Ophthalmol

View full text Add to dashboard Cite

AIM: To demonstrate the clinical features, the risk factors, the visual prognosis and the recurrence of cytomegalovirus (CMV) retinitis (CMVR) in HIV-negative patients. METHODS: HIV-negative patients with CMVR were involved in this study. Best corrected visual acuity (BCVA), intraocular pressure (IOP), CMV-DNA load in aqueous and/or serum samples, treatment, follow-up time, recurrence and complications were recorded. Ocular characteristics were evaluated by fundus photographs. Association between ocular factors and visual prognosis were analyzed by regression analysis. RESULTS: Twenty-five eyes of 16 patients were included. All 25 eyes underwent intravitreal injections of anti-viral agents. The mean logMAR BCVA improved from 0.94±0.98 (0.98-0.78) initially to 0.77±0.73 (0.82-0.68) at last visit, but not significantly. After antiviral treatment, the aqueous CMV DNA load significantly reduced to (3.42±1.47)×102 copies/mL (P=0.001), compared with (2.51±3.11)×105 copies/mL at baseline. Macular involvement (R2=0.475, P=0.049) and initial visual acuity (R2=0.475, P=0.017) were significantly associated with the poor visual prognosis (BCVA<20/400). The extent of retinal lesions (R2=0.064, P=0.04) was significant associated with the risk of recurrence of CMVR. CONCLUSION: Intravitreal injection of anti-viral agents offers a safe and effective treatment for CMVR. Macular involvement and initial visual acuity significantly associate with visual prognosis. The extent of retinal lesions is significantly associated with the recurrence of CMVR. These ocular factors can be used as predictive risk factors for long term visual prognosis in HIV-negative CMVR patients.

show abstract

“…Some researchers employ the term "oncomodulation" to explain HCMV's role in malignancies, even though human CMV is not an oncogenic virus. The fact that HCMV is frequently found in tumor tissues could be explained by the fact that it promotes tumor growth while not being an oncogenic virus (Kwon et al, 2021). Oncomodulation occurs when HCMV infects tumor cells and alters their aggressiveness (Touma et al, 2021).…”

Section: The High Presence Of Hcmv Pp71 Proteins Correlate With P63 E...mentioning

confidence: 99%

The High Presence of HCMV pp71 Proteins, Correlate with P63 Expression in Pancreatic Cancer Tumor Tissue

Abdul-Razzaq¹,

Jassim

Mahmood

2023

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Objective: The purpose of this retrospective investigation was (1) to screen the existence of HCMV in pancreatic cancer tissues in relation to the histopathological grading system of such tumor tissues. (2) To evaluate the expression of the (P63) tumor suppressor gene in these tissues. (3) To find out the impact of the coexistence of (HCMV) along with the p63 on the occurring histopathological alterations. Methods: The current retrospective cohort study included 35 paraffinized pancreatic tissues from the archives of major hospitals and numerous private histopathological laboratories from 2015 to 2020. (Twenty-five pancreatic carcinomatous tissues and 10 biopsies from seemingly normal pancreatic tissues were examined). Tissue slices from the desired tissue blocks were subjected to the immunohistochemistry (IHC) technique to detect Human Cytomegalovirus pp71 and tumor suppressor P63 proteins with aid of monoclonal primary antibodies. Results: The HCMV pp71 proteins were found in 92% (23 out of 25) of pancreatic tumor tissues, while it was in two (20%) of healthy pancreatic tissues. in comparison, the p63 proteins were found in 76% (19 out of 25) of tumor tissues and in four (40%) of their correlative healthy tissues. Conclusion: The increased expression of HCMV in malignant pancreatic tissue may indicate its primary or secondary role in the emergence of this type of cancer, whereupon HCMV inactivation may be useful in the treatment of this type of cancer. On the other hand, p63’s high levels of expression in malignant pancreatic tumors reflect either an oppressive function or an unfortunate mutation that prevents it from functioning.

show abstract

Clinical Characteristics Associated with the Development of Cystoid Macular Edema in Patients with Cytomegalovirus Retinitis

Cited by 5 publications

References 15 publications

CMV retinitis and subsequent acute cystoid macular oedema after treatment with vitreous ganciclovir injection: a case report

CMV retinitis and subsequent acute cystoid macular oedema after treatment with vitreous ganciclovir injection: a case report

Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China

The High Presence of HCMV pp71 Proteins, Correlate with P63 Expression in Pancreatic Cancer Tumor Tissue

Contact Info

Product

Resources

About