Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

Abstract

Background: An outbreak of pneumonia associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city and then to other city. It is very urgent to delineate the epidemiological and clinical characteristics of these affected patients. Methods: To investigate the epidemiological characteristics of the COVID-19, we describe a case series of 459 patients with con rmed COVID-19 in WZ of China from January 27 to February 12, 2020. Results: The median age of all patients was 48.0 years, and 46.8% were females. 37.5% of patients had a history of residence in Wuhan. Fever (72.1%) and cough (43.6%) were the most frequent symptoms. In addition, three kinds of unconventional cases were observed, in which included 4.4% con rmed virus carrier who were asymptomatic, 7.8% con rmed patients who had no link to Wuhan city but contact with individuals from Wuhan without any symptoms at the time of contact, and 10.7% con rmed patients who had no link to Wuhan city nor a history of intimate contact with patients or individuals from Wuhan without any symptoms, respectively. Conclusion: Our ndings presented the possibility of asymptomatic carriers affected with SARS-CoV-2, and this phenomenon suggested that chances of uncontrollable transmission in the larger population might be higher than formerly estimated, and transmission by these three kinds of unconventional patients in WZ may be one of the characteristics of infection in other Chinese cities outside the Wuhan epidemic area.

Novel coronavirus infection and pregnancy

“…In addition, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), two notable strains of the coronavirus family, are both known to be responsible for severe complications during pregnancy, including the need for endotracheal intubation, admission to an intensive care unit (ICU), renal failure and death 7,8 . In general, both studies reported that the clinical characteristics of the pregnant women with COVID-19 pneumonia were similar to those of non-pregnant adult patients who developed COVID-19 pneumonia [2][3][4] . Chen et al 9 reported the clinical characteristics of nine pregnant women with laboratory-confirmed COVID-19 in the third trimester, which comprised mainly fever and cough.…”

Effective strategies to prevent coronavirus disease-2019 (COVID-19) outbreak in hospital

“…As of 23 rd February 2020, 26 cases (16 imported and 10 indigenous) of COVID-19 had been diagnosed in Taiwan [2]. Notably, hospital-associated transmission of the COVID-19 to health-care workers and hospitalized patients has been reported [3]. Furthermore, Zou et al revealed that similar viral loads are seen in asymptomatic and symptomatic patients, indicating the transmission potential of asymptomatic patients [4].…”

Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2

“…The outbreak of an epidemical pneumonia with initially unknown reasons in December 2019 in Wuhan, China was ultimately found to be caused by a new virus, the "2019 novel Coronavirus" (2019-nCoV) or SARS-CoV-2 formally named by the World Committee on Virus Classification, [1][2][3] and the disease caused by this virus was named as COVID-19 by the World Health Organization. 4 , 5 This virus has a characteristic crown representing the spike peplomers on the viral envelope, with strong infectivity and general suscepti-bility to people of all ages and across the globe.…”