Clinical characteristics of 159 cases of acute toxic hepatitis

Abstract

The main cause of acute toxic hepatitis in the current study was the use of herbal medicines. The severity of liver injury at the time of admission was a major factor significantly associated with the hospitalization and recovery periods.

Heteroside-321 Hepatoregeneration Activity In Cases Of Hepatitis Inducted By Local Hyperthermia

“…Local liver hyperthermia (45 ° C -10 min) was followed by necrosis of some cells, blood disorder and the development of the inflammatory response, manifested as typical autotoxic hepatitis [21]. The level of disease development was determined by the content of the connective tissue and the abuse of detoxification function.…”

A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis

“…According to a recent retrospective research on 159 patients hospitalized for toxic hepatitis, 41.5% was caused by oriental medicine and 24.5% was by folk drugs such as Dictamnus, Perennial Artemisia, Ginseng, kudzu and Sanghwang Mushroom [3]. Efficacy and safety of all medicines should be secured including herb medicine and health supplements since overuse or misuse can lead to development of diseases.…”

“…However, there hasn't been many studies on pharmacokinetics, internal metabolism, proper usage and side effects of hovenia dulcis. In Korea, two cases of toxic hepatitis have been reported in adult patients after ingesting hovenia dulcis [3,6], but there has not yet been any report on toxic hepatitis in children.…”

“…In pathology, drug induced liver injury may appear as hepatic cell inflammation or cholestasis or a mixed condition of both [1,2]. In Korea, as many people are highly concerned about health and tend to engage in taking health supplements, toxic hepatitis accounts for much cases of acute hepatitis [3]. It was reported that adults showed a frequency of toxic hepatitis out of all cases of hepatitis in Korea ranging from 2% to 40%, while children showed approximately 15%, and oriental medicine was assumed to be the most common cause of toxic hepatitis [3,4].…”

“…In Korea, as many people are highly concerned about health and tend to engage in taking health supplements, toxic hepatitis accounts for much cases of acute hepatitis [3]. It was reported that adults showed a frequency of toxic hepatitis out of all cases of hepatitis in Korea ranging from 2% to 40%, while children showed approximately 15%, and oriental medicine was assumed to be the most common cause of toxic hepatitis [3,4]. Many Korean children face imprudent use of a variety of oriental medicine given by their parents for the purpose of better growth and physical constitution improvement, and for this reason the frequency of toxic hepatitis seems actually higher than the previous report.…”