Clinical characteristics of 312 hospitalized older patients with COVID-19 in Wuhan, China

Abstract

Highlights Most of the patients with COVID-19 who need to be admitted to hospital are older. Older patients with COVID-19 had much more co-morbidity, complications and mortality. Age, SOFA score, APACHEⅡ score, platelet count＜125 × 109/L, d-dimer, creatinine＞133 μmol/L, interleukin-6, and lung consolidation on admission were independent risk factors for severe cases among older patients with COVID-19. More attention should be paid to older patients with COVID-19.

Assessing the Elevation of Cardiac Biomarkers and the Severity of COVID-19 Infection: A Meta-analysis

“…Various comorbidities were assessed and compared between two groups, except Medetalibeyoglu et al and Zheng et al studies which did not assess comorbidities of the subjects (12,13). The comorbidities that were more significantly common in the severe groups included cardiovascular diseases (i.e., coronary artery disease, heart failure) in ten studies (14-24), hypertension in nine studies (14, 16-19, 21, 22, 24, 25), chronic respiratory diseases in nine studies (17,19,20,(23)(24)(25)(26)(27)(28), diabetes mellitus in seven studies (11,16,18,21,22,25,29), cerebrovascular diseases in five studies (15,16,18,21,24), chronic kidney disease in four studies (18,(22)(23)(24), cancer in one study (25), and immunosuppression in one study (17). Four studies did not find significant association between the infection severity and the patients' comorbidities (30)(31)(32)(33).…”

“…Only eight studies in our analysis described the active treatments for COVID-19 infection and empiric treatment for bacterial and/or fungal coinfections during hospitalization (21,22,28,29,32,33,38,43). These treatments included antiviral agents (i.e., arbidol, oseltamivir, lopinavir-ritonavir, ribavirin, ganciclovir, interferon-alpha), antibiotics (i.e., fluoroquinolones, cephalosporins, imipenem or meropenem, linezolid, penicillins, azithromycin), antifungal agents, glucocorticoid (i.e., methylprednisone), unspecified corticosteroid, and immunoglobulin.…”

Death risk stratification in elderly patients with covid-19. A comparative cohort study in nursing homes outbreaks

“…The recent pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) around the world has put aged people in front of a devastating horizon. As a matter of fact they make up around 30 % of all cases, 45−50% of all hospitalizations, and 80 % of all deaths ( Anonymous, 2020 ; Instituto de Salud Carlos III, 2020 ; Li, Lu, & Zhang, 2020 ). In these age strata SARS-CoV-2 disease (COVID-19) lethality rate can reach up to 50 % ( Anonymous, 2020 ; Li et al, 2020 ).…”

“…As a matter of fact they make up around 30 % of all cases, 45−50% of all hospitalizations, and 80 % of all deaths ( Anonymous, 2020 ; Instituto de Salud Carlos III, 2020 ; Li, Lu, & Zhang, 2020 ). In these age strata SARS-CoV-2 disease (COVID-19) lethality rate can reach up to 50 % ( Anonymous, 2020 ; Li et al, 2020 ). This increased mortality may be explained in part by already known risk factors (frailty, infection acting as a trigger to decompensate other chronic conditions, immunosenescense, and development of geriatric syndromes' cascade) ( Napoli, Tritto, Mansueto, Coscioni, & Ambrosio, 2020 ); but in the actual world's alarm context, there are other evident or subtle reasons, like health-care systems collapse, lack of material and human resources, and disaster situations involving ethical issues, which are contributing to this poor results ( Grasselli, Pesenti, & Cecconi, 2020 ; Mannelli, 2020 ; Peterson, Largent, & Karlawish, 2020 ; Rosenbaum, 2020 ; Steinberg, Balakrishna, Habboushe, Shawl, & Lee, 2020 ).…”

“…The significance of co-morbidities in the outcome of multiple acute diseases has largely been demonstrated ( Greenfield, Apolone, & McNeil, 1993 ; Kaplan & Feinstein, 1973 ; Lang & Mancini, 2007 ; Perkins et al, 2004 ). Nevertheless, in most initial series of COVID-19, the impact of underlying chronic conditions in morbidity and mortality has been only partially analyzed, whereas most focus had been put in acute symptoms and laboratory parameters ( Li et al, 2020 ). However, in a recent large multicenter cohort of patients with COVID-19, chronic cardiac disease, non-asthmatic chronic pulmonary disease, chronic kidney disease, liver disease and obesity were associated with higher in-hospital mortality ( Docherty, Harrison, & Green, 2020 ).…”