Clinical characteristics of acute lymphoblastic leukemia in male and female patients: A retrospective analysis of 705 patients

Li, Suyi; Ye, Jieyu; Meng, Fan‐Yi; Li, Chunfu; Yang, Mei

doi:10.3892/ol.2015.3202

Cited by 21 publications

(22 citation statements)

References 31 publications

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“…16,18,19 In this study, ALL incidence was observed more in male gender (M: F= 1.3:1) matching the finding of further studies, whereas it reached 1.84:1 in others. 11,15,[20][21][22] The commonest complaint of the study patients was fever, followed by bone pain, weight loss, and fatigability, these were consistent with findings by other studies. 23,24 Bone pain was presented in 22 patients (40%), it was variably reported by many studies (19-67%), Joint pain was present in one (1.8%) patient only (ankle joint), whereas it was presented more (6-9.3%) by other studies.…”

Section: Discussionsupporting

confidence: 81%

“…14 The most common age of initial clinical presentation of ALL in the current study was between 1 and 10 years old (81.8%, p value=.000), these data were comparable to other studies. 10,15 Under one-year old and over 10 years old accounted for 2.6% and 14.6%, respectively. Historically, the age of presentation has a clear relationship to outcome of ALL; the age above one year -10 years, which was the most concerned age group in this study, is the most favorable age group in contrast to other age groups.…”

Section: Discussionmentioning

confidence: 99%

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Clinical, hematological, and laboratory presentation of acute lymphoblastic leukemia of children in Diyala province/Eastern Iraq

Shalal¹,

Mahmood

Alchalabi³

2017

Int J Res Med Sci

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Background: To show the initial presenting features the children of acute lymphoblastic leukemia presented till the diagnosis at oncology Center/ Diyala/ Iraq.Methods: A retrospective study, carried out during 2016-2017. The data include constitutional, hematological, and infiltrative features with laboratory findings registered at patient’s files until the diagnosis. Data were analyzed by Statistical Package of Social Sciences v. 20.Results: The total patients were 55, distributed into: T- cell (10.9%) and B- cell leukemia (89.1%), FAB classification include L1 (11%), L 2 (89%) and L3 (0%). Most of patients presented at 1- 10 years of age (p value= 0.000); M: F= 1.3:1 (p value= 0.345). Fever and pallor were the most common features, 81.8% (p value=0.000) and 67.3% (p value=0.010), respectively. Other features were bone pain (40%), anorexia (36.4%), fatigability (30.9%), muco-cutaneous bleeding (27.3%), hepatosplenomegaly (56.4%), lymphadenopathy (49.1%), and facial palsy (1.8%). Hemoglobin was < 8 gm/ dl in 70.9 %, white cell count was < 50×109 cells/L in 70.9 %; 12.3% has severe leukocytosis, and platelets' count was between 20- 100 × 109 cells/L in 49%. Mediastinal infiltration (7.2%), pleural effusion (1.8%), pericardial effusion (1.8%), and positive cytospin (5.4%).Conclusions: L2 subtype was the dominant subtype; this contrary to all other studies and may be related to the prognosis. Most of the initial features were general and may indicate more common illnesses, but their constellation with complete blood picture should rise the possibility of leukemia. A rare complication, pleural effusion, was detected as initial feature.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Clinical, hematological, and laboratory presentation of acute lymphoblastic leukemia of children in Diyala province/Eastern Iraq

Shalal¹,

Mahmood

Alchalabi³

2017

Int J Res Med Sci

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“…Among Chinese patients, the mean age of presentation was significantly higher in females than males (19.5 years vs 16.4 years, P = .007). Percentage of patients positive for Philadelphia chromosome did not differ in the two groups (17.7% in males and 17.4% in females, P = .93) 13 . However, in our study, age at presentation though marginally higher in females, did not differ significantly among males and females (39.5 years in females and 35 in males, P = .10).…”

Section: Resultscontrasting

confidence: 76%

“…BCR‐ABL positivity is associated with older age and higher white cell counts 12 . Male preponderance in ALL as well as younger age at presentation has been reported by investigators 13 . MLL gene rearrangements have been reported in 20% of ALL, of which 10% are seen in older children and adults 14 .…”

Section: Introductionmentioning

confidence: 86%

Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters

2020

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Background Recurrent genetic abnormalities influence prognosis in B lymphoblastic leukemia. BCR‐ABL rearrangement is associated with higher leukocyte counts and older age at presentation. Among adults, BCR ‐ABL ‐ is the commonest recurrent abnormality whereas, IgH rearrangements are rare. Aim Aim of this study was to identify common recurrent genetic abnormalities in adult B ALL and study their association with hematological findings. Methods Bone marrow and peripheral blood from patients with B acute lymphoblastic leukemia were analyzed for complete blood counts, bone marrow morphology and cytogenetic abnormalities. The study group was divided into smaller groups based on cytogenetic abnormalities. Hematological parameters and presence of recurrent genetic abnormalities was compared across age groups and gender by non parametric tests. Results BCR‐ABL positive group had a higher leukocyte count than BCR‐ABL negative group. Among groups 1 to 5, group 1 with gains of chromosomes was associated with leucopenia and higher age at presentation. BCR‐ABL is commonest recurrent abnormality followed by IgH rearrangements. Conclusion Patients with gains of chromosomes alone have low total leukocyte counts at presentation.

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“…A study conducted in southern India showed a male-to-female ratio of 1.6:1, while a similar study conducted in China reported a 1.84:1 male-to-female ratio. [ 12 13 ] The reason for the observed male preponderance of the ALL cases is unclear. Most of the cases were associated with children, and this finding is consistent with findings in other countries.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of fusion oncogenes in zambian patients with acute lymphoblastic leukemia

Okuku

Kwenda

Samutela

et al. 2020

Int J App Basic Med Res

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Introduction: Chromosomal aberrations play a significant role in the pathogenesis of acute lymphoblastic leukemia (ALL) with prognostic and therapeutic implications. Despite the availability of molecular tools, low-resource settings struggle to diagnose the disease due to limited diagnostic capacity. The objective of this study was to detect common chromosomal aberrations in patients with ALL attending the University Teaching Hospital (UTH) in Lusaka, Zambia. Materials and Methods: In this prospective study, 19 blood samples from patients with ALL were screened for the presence of BCR-ABL, E2A-PBX1, MLL-AF4, and ETV6-RUNX1 fusion oncogenes using reverse transcriptase-polymerase chain reaction assay. Blood counts and clinical characteristics of patients were also assessed. Results: The age of patients ranged from 1½ to 72 years and comprised 57.9% of males and 42.1% of females. The majority of these patients were children (68%), and adults only comprised 32%. Only BCR-ABL and E2A-PBX1 oncogenes were detected in 3/19 of cases. The BCR-ABL gene was detected in a 4-year-old female child and a 15-year-old child. Both cases were associated with hepatomegaly and anemia coupled with low hemoglobin, white blood cell, and platelet counts. E2A-PBX1 was detected in a 12-year-old child with lymphadenopathy and splenomegaly, coupled with low hemoglobin, white blood cell, and platelet counts. All the three patients who harbored these fusion oncogenes died. Conclusion: This is the first study from Zambia to investigate the presence of fusion oncogenes in leukemia patients, which were found only among the older children population. Based on these findings, we recommend that molecular diagnosis be made a priority for the younger leukemia patient population at UTH.

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Clinical characteristics of acute lymphoblastic leukemia in male and female patients: A retrospective analysis of 705 patients

Cited by 21 publications

References 31 publications

Clinical, hematological, and laboratory presentation of acute lymphoblastic leukemia of children in Diyala province/Eastern Iraq

Clinical, hematological, and laboratory presentation of acute lymphoblastic leukemia of children in Diyala province/Eastern Iraq

Recurrent genetic abnormalities detected by FISH in adult B ALL and association with hematological parameters

Molecular detection of fusion oncogenes in zambian patients with acute lymphoblastic leukemia

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