Clinical characteristics of acute pancreatitis in children: a single-center experience in Western China

Abstract

Background The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the risk factor for acute recurrent pancreatitis (ARP) in children. Method From June 2013 to June 2019, a total of 130 pediatric patients with AP at the inpatient database were enrolled. Univariate analysis and multivariate Cox regression analysis were performed to identify the risk factors for ARP in children. Result Major etiologic factors in 130 patients were biliary (31.5%), idiopathic (28.5%). The etiology of pancreatitis in children was markedly different from that in adults (p < 0.001). Compared with the adult patients, the pediatric patients had significantly lower severity (p = 0.018) and occurrence rate of pancreatic necrosis (p = 0.041), SIRS (p = 0.021), acute peripancreatic fluid collection (p = 0.014). Univariate and Multivariate Cox regression analysis showed that female (p = 0.020; OR 3.821; 95% CI 1.231–11.861), hypertriglyceridemia (p = 0.045; OR 3.111; 95% CI 1.024–9.447), pancreatic necrosis (p = 0.023; OR 5.768; 95% CI 1.278–26.034) were the independent risk factors of ARP. Hypertriglyceridemia AP had the highest risk of recurrence compared to other etiology (p = 0.035). Conclusion Biliary and idiopathic disease were the major etiologies of AP in children. Children have simpler conditions than adults. Female, hypertriglyceridemia, and pancreatic necrosis were associated with the onset of ARP.

Acute Pancreatitis and Recurrent Acute Pancreatitis in Children: A 10-Year Retrospective Study

“…This study shows that the incidence of SAP in pediatric AP was 10.2%, which is similar to a previous report (12.8%) [4]. The severity of AP in children is lower than that in adults, which may be related to the etiology, complications, and pancreatic necrosis [14]. In this study, the incidence of acute necrotic collection was 2.9%, which was lower than that in a previous study (4.6%) [14].…”

“…The severity of AP in children is lower than that in adults, which may be related to the etiology, complications, and pancreatic necrosis [14]. In this study, the incidence of acute necrotic collection was 2.9%, which was lower than that in a previous study (4.6%) [14]. Raizner et al reported necrotizing pancreatitis developed in less than 1% of pediatric AP and they suggested that necrotizing pancreatitis in children was associated with severe acute and late complications in children [15].…”

“…A previous study from the United States found that idiopathy (31%) and drug-related (23%) were the main causes of AP in 115 children [4]. A study involving 130 children with AP showed that biliary tract infection (31.5%), idiopathy (28.5%), and trauma (16.2%) were the main reasons [14]. In our study, the top three A meta-analysis of 48 studies showed that the top three causes in different continents were gallstones (33%), systemic disease (31%), and infection (29%) in Asia; trauma (32%), idiopathy (25%), systemic disease (16%), and infection (16%) in Oceania; and idiopathy (26%), systemic disease (13%), and infection (13%) in Europe [5].…”

Risk Factors, Clinical Features, and Outcomes of Acute Pancreatitis in Children in Endemic Zone of Ascariasis in Eastern Bihar: A Hospital-Based Study

“…Poddar et al studied 320 children with AP in India in 2017 and found that trauma (21%) and biliary tract diseases (10%) were the most common causes of AP in children [ 15 ]. Zhong et al (2021), from China, studied 130 children with AP and found that biliary tract diseases (31%) and idiopathic (28%) were the most common risk factors [ 16 ]. In another study of 115 children in the United States published in 2019, idiopathic (31%) and drugs (23%) were the most common risk factors.…”

“…The diseases (31%) and idiopathic (28%) were the most common risk factors [16]. In another study of 115 children in the United States published in 2019, idiopathic (31%) and drugs (23%) were the most common risk factors.…”