Clinical Characteristics of Bilateral <scp>M</scp>eniere's Disease in a Single <scp>A</scp>sian Ethnic Group

Suh, Michelle J.; Jeong, Junhui; Kim, Hyun Ji; Jung, Jinsei; Kim, Sung Huhn

doi:10.1002/lary.27423

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…Instead, we performed a comparative study with definite Meniere's disease to show the similarity of inner ear status between vestibular and of definite Meniere's disease. Nonetheless, according to the previous reports using the same inner ear MRI methods as the present study, the positivity rate of EH in healthy groups was 38.1% for c-EH and 7.1% for v-EH (16). Therefore, the positivity rates of c-EH (62.5%) and v-EH (68.8%) in our patients with vestibular Meniere's disease seem sufficiently higher than those in healthy controls.…”

Section: Limitations and Conclusionsupporting

confidence: 73%

“…In general, Meniere's disease affects one side of the ears. Several studies reported that the incidence of bilateral Meniere's disease was 2-47%, depending on the length of follow-up and strictness of adherence to the criteria for diagnosis (15,16). Recently, inner ear MRI scans have demonstrated the existence of EH in the unaffected ear in patients with Meniere's disease.…”

Section: Eh In Meniere's Diseasementioning

confidence: 99%

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Is Vestibular Meniere's Disease Associated With Endolymphatic Hydrops?

et al. 2020

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Background: Vestibular Meniere's disease (American Academy of Ophthalmology and Otolaryngology, 1972) also known as possible Meniere's disease (American Academy of Otolaryngology Head and Neck Surgery, 1995) or vestibular type of atypical Meniere's disease (V-AMD) (Japan Society for Equilibrium Research, 2017) is characterized by an episodic vertigo without hearing loss. Though named as Meniere's disease (MD), this entity may not be caused solely by endolymphatic hydrops (EH).Objective: To estimate the role of EH in vestibular Meniere's disease in comparison with definite Meniere's disease.Methods: Thirty patients with unilateral definite MD and 16 patients with vestibular Meniere's disease were included. Those who met the criteria for definite or probable vestibular migraine were excluded. All patients underwent vestibular assessments including inner ear MRI 4 h after intravenous gadolinium injection, bithermal caloric testing, directional preponderance of vestibulo-ocular reflex in rotatory chair test, cervical- and ocular-vestibular evoked myogenic potential, stepping test, dizziness handicap inventory (DHI), and hospital anxiety and depression scale (HADS). All above tests and frequency/duration of vertigo spells were compared between vestibular Meniere's disease and MD.Results: Even in unilateral MD, cochlear and vestibular endolymphatic hydrops (c-, v-EH) were demonstrated not only in the affected side but also in the healthy side in more than half of patients. Positive rate of v-EH in vestibular Meniere's disease (68.8%) was as high as that of MD (80%). In vestibular Meniere's disease, the number of bilateral EH was higher in the vestibule (56.3%) than that in the cochlea (25.0%). There were no differences in vestibular tests and DHI between vestibular Meniere's disease and MD; however, the frequency of vertigo spells was lower in vestibular Meniere's disease (p = 0.001). The total HADS score in the MD group was significantly higher than that in the vestibular Meniere's disease group.Conclusions: MD is a systemic disease with bilateral involvement of inner ears. V-EH is a major pathophysiology of vestibular Meniere's disease, which would precede c-EH in the development of vestibular Meniere's disease, a milder subtype of MD. MRI is useful for differentiating MD from other vertigo attacks caused by different pathologies in bringing EH into evidence.

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Section: Limitations and Conclusionsupporting

confidence: 73%

Section: Eh In Meniere's Diseasementioning

confidence: 99%

Is Vestibular Meniere's Disease Associated With Endolymphatic Hydrops?

et al. 2020

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“…This agrees with our study. Usually, the second ear would be affected only to a mild tinnitus or fullness [17]. On the other hand, bilateral involvement was observed in about one third of MD cases.…”

Section: Discussionmentioning

confidence: 99%

Value of Vestibular Evoked Myogenic Potentials in IdentifyingDifferent Forms of Endolymphatic Hydrops: A Cross-Sectional Study

Taha¹,

Nada

Rahman³

et al. 2021

The Medical Journal of Cairo University

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Background: Meniere's disease is idiopathic Endolymphatic Hydrops. Vestibular evoked myogenic potential is a neurophysiological assessment technique that is used determine the function of the otolith organs of the inner ear. Using vestibular evoked myogenic potential tests may identify the different forms of the Endolymphatic Hydrops. Aim of Study: The aim of this study is to explore the role of vestibular evoked myogenic potentials (VEMP) in diagnosis of the different kinds of Meniere's disease (MD). Patients and Methods: Three groups of patients that were selected according to the diagnosis, definitive MD (DMD), cochlear MD (CMD) and recurrent vestibulopathy (RV) group. Basic audiological evaluation was carried out. It included Pure tone audiometry, speech audiometry, acoustic immittance testing and electrocochleography. Otolith function assessment was carried out in the form of: Cervical VEMP (c-VEMP) and ocular VEMP (o-VEMP). Vestibular assessment was carried out: The test protocol included spontaneous nystagmus, gaze test, oculomotor tests, positioning test (Dixhallpike), positional nystagmus, and caloric testing. The three groups were compared for all demographic variables as well as clinic-pathologic variables, and tests results. Results: The overall sample was 40 cases; 13 with DMD, 10 with CMD and 17 with RV. The mean age is variable between groups (p-value <0.001) with the highest in the DMD group (38.3±7.4 years) and the lowest in the CMD group (25.2±4.6 years). The male to female ratio is variable between groups of the study (p-value=0.03) with the highest ratio 9:4 in the DMD group. There was a significant difference between groups (p<0.001) regarding dizziness. Asymmetric response of c-VEMP was seen in nine (9/13) (69.2%) of DMD cases, (14/17) (82.4%) of RV cases and only in three (3/10) (30%) of CMD cases, (p-value <0.001). Low amplitude of o-VEMP was seen in (11/13) (84.6%) of DMD cases, (9/10) (90%) of CMD cases, (15/17) (88.2%) of RV cases, and only in two (25%) of normal cases, (p-value=0.002). A significant difference was found between definitive and cochlear Meniere's as

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“…Autoimmune pathologies are considered to be related to MD, including autoimmune arthritis ( 4 ) and thyroid diseases ( 5 ). A familial predisposition to the development of MD has also been described ( 6 ), especially for BMD ( 7 , 8 ), and ethnic differences were shown in epidemiologic and genetic features ( 9 ). In addition, patients with BMD were reported to have a higher frequency of delayed MD ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…A familial predisposition to the development of MD has also been described ( 6 ), especially for BMD ( 7 , 8 ), and ethnic differences were shown in epidemiologic and genetic features ( 9 ). In addition, patients with BMD were reported to have a higher frequency of delayed MD ( 9 ). The concept of delayed MD is not different from delayed endolymphatic hydrops (DEH).…”

Section: Introductionmentioning

confidence: 99%

Characteristics of clinical details and endolymphatic hydrops in unilateral and bilateral Ménière's disease in a single Asian group

Shi

Wang

et al. 2022

Front. Neurol.

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ObjectivesTo elucidate the characteristics of the clinical details and endolymphatic hydrops (EH) in bilateral Ménière's disease (BMD).MethodsA total of 545 patients with definite MD were enrolled. Demographic variables; the age of onset; disease course; inner ear function; the coexistence of related disorders such as migraine, delayed MD, drop attacks, and autoimmune diseases; familial history; and characteristics of EH were analyzed.ResultsIn the study population, the prevalence of BMD was 15.4%. The disease duration of BMD (84.0 ± 89.6 months) was significantly longer than that of unilateral MD (UMD, 60.1 ± 94.0 months) (P = 0.001). As evaluated by hearing thresholds and cervical and ocular vestibular evoked myogenic potentials, inner ear functions were more deteriorated in BMD (P < 0.05) than in UMD. The proportions of delayed MD and a family history of vertigo were significantly larger in BMD (P < 0.05). EH was observed in 100% of cases on the clinically affected side and 6.1% of cases on the unaffected side.ConclusionA low prevalence of BMD, longer disease duration, higher frequencies of delayed MD, and family history of vertigo in patients with BMD were significant findings observed in the present study. All affected ears presented with EH, and a low percentage of unaffected sides presented with EH.

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Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group

Cited by 9 publications

References 32 publications

Is Vestibular Meniere's Disease Associated With Endolymphatic Hydrops?

Is Vestibular Meniere's Disease Associated With Endolymphatic Hydrops?

Value of Vestibular Evoked Myogenic Potentials in IdentifyingDifferent Forms of Endolymphatic Hydrops: A Cross-Sectional Study

Characteristics of clinical details and endolymphatic hydrops in unilateral and bilateral Ménière's disease in a single Asian group

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