Clinical characteristics of chemical sensitivity: an illustrative case history of asthma and MCS.

Ross, Gerald H.

doi:10.1289/ehp.97105s2437

Cited by 26 publications

(10 citation statements)

References 24 publications

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“…One of the key features of individuals with CI/MCS is their sensitivity/intolerance to a variety of chemically unrelated compounds, whose mechanisms of action are not known 3. The FSL rat is also more sensitive to a variety of chemically diverse compounds, so it shares a superficial resemblance to individuals with CI/MCS.…”

Section: Chemical Intolerance (Ci)/multiple Chemical Sensitivity (Mcs)mentioning

confidence: 99%

“…Patients suffering from multiple chemical sensitivity (MCS) or chemical intolerance (CI) frequently report symptoms that overlap with those reported by patients suffering from chronic fatigue syndrome and/or asthma 1–4. The overlap in the prevalence of these conditions suggests that there might be some underlying common mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, a patient's hyperresponsiveness to the cholinergic agonist methacholine is commonly used to confirm a diagnosis of asthma. Therefore, the pervasiveness of the cholinergic system makes it a likely candidate to be involved in the multi‐organ complaints frequently reported by individuals with CI, including difficulties in concentration, irritable bowel, and asthma 1,3…”

Section: Introductionmentioning

confidence: 99%

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A Genetic Rat Model of Cholinergic Hypersensitivity: Implications for Chemical Intolerance, Chronic Fatigue, and Asthma

Overstreet

Djuric

2001

Annals of the New York Academy of Sciences

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The fact that only some individuals exposed to environmental chemicals develop chemical intolerance raises the possibility that genetic factors could be contributing factors. The present communication summarizes evidence from a genetic animal model of cholinergic supersensitivity that suggests that an abnormal cholinergic system could be one predisposing genetic factor. The Flinders Sensitive Line (FSL) rats were established by selective breeding for increased responses to an organophosphate. It was subsequently found that these FSL rats were also more sensitive to direct‐acting muscarinic agonists and had elevated muscarinic receptors compared to the selectively bred parallel group, the Flinders Resistant Line (FRL) rats, or randomly bred control rats. Increased sensitivity to cholinergic agents has also been observed in several human populations, including individuals suffering from chemical intolerance. Indeed, the FSL rats exhibit certain behavioral characteristics such as abnormal sleep, activity, and appetite that are similar to those reported in these human populations. In addition, the FSL rats have been reported to exhibit increased sensitivity to a variety of other chemical agents. Peripheral tissues, such as intestinal and airway smooth muscle, appear to be more sensitive to both cholinergic agonists and an antigen, ovalbumin. Hypothermia, a centrally mediated response, is more pronounced in the FSL rats after nicotine and alcohol, as well as agents that are selective for the dopaminergic and serotonergic systems. In some cases, the increased sensitivity has been detected in the absence of any changes in the receptors with which the drugs interact (dopamine receptors), while receptor changes have been seen in other cases (nicotine receptors). Therefore, there may be multiple mechanisms underlying the multiple chemical sensitivity‐chemical intolerance of the FSL rats. An elucidation of these mechanisms may provide useful clues to those involved in chemical intolerance in humans.

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Section: Chemical Intolerance (Ci)/multiple Chemical Sensitivity (Mcs)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Genetic Rat Model of Cholinergic Hypersensitivity: Implications for Chemical Intolerance, Chronic Fatigue, and Asthma

Overstreet

Djuric

2001

Annals of the New York Academy of Sciences

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“…CFS was found in 88.5% and 68.1% of non-occupational and occupational cases of MCS, respectively (Nogué Xarau et al, 2010). Patients with MCS or sometimes CFS may present with headaches; airway symptoms, especially upper airway symptoms; sometimes cutaneous symptoms; and/or adverse drug reactions to multiple medications (Baraniuk & Zheng, 2010;Ferre Ybarz et al, 2005;Nijs et al, 2003;Ross, 1997;Ziem & McTamney, 1997).…”

Section: Mcs Signs and Symptomsmentioning

confidence: 99%

A Comparison of Multiple Chemical Sensitivity with Other Hypersensitivity Illnesses Suggests Evidence and a Path to Answers

Dennison¹

2017

Ecopsychology

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Throughout history, when doctors and scientists have encountered illnesses that were not clearly visible and didn't have an obvious explanation, those illnesses have often been dismissed as either not real or as psychological. Asthma was among the illnesses once thought to be psychological. In order for doctors and researchers to reach similar conclusions about multiple chemical sensitivity, they have had to overlook a great deal of valuable evidence including the signs and symptoms of patients as well as the commonalities this illness shares with other now well-recognized hypersensitivity illnesses. Researching the relationship between multiple chemical sensitivity and other hypersensitivity illnesses may help narrow down the potential mechanisms in this illness and bring answers to patients, which might ease the burden of having an illness that is once again unrecognized by the people patients are most dependent on for help.

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“…Studies have been conducted of suspected triggers of MCS (Figure 2). In one study, surgical procedures performed with anesthetics were found to be MCS triggers by 7% of 200 patients 8 . The literature noted that some MCS patients had experienced bronchospasm with wheezing, stridor, and tracheal infections after undergoing surgery.…”

Section: Literature Reviewmentioning

confidence: 99%

Perioperative Care of Environmentally Sensitive Patients

Koch

Huggins²

1998

AORN Journal

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In today's complex environment, with an increasing number of chemicals and environmental contamination, some individuals have developed sensitivities to their surroundings. Surgical intervention for environmentally sensitive patients provides an opportunity to reach beyond the boundaries of the OR. These patients require highly individualized perioperative nursing assessments and care planning on a multidisciplinary level. Presbyterian Hospital of Dallas has developed a protocol to initiate collaborative planning for these patients and has had the opportunity to successfully care for these patients.

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Clinical characteristics of chemical sensitivity: an illustrative case history of asthma and MCS.

Abstract: 437-441 (1997)

Cited by 26 publications

References 24 publications

A Genetic Rat Model of Cholinergic Hypersensitivity: Implications for Chemical Intolerance, Chronic Fatigue, and Asthma

A Genetic Rat Model of Cholinergic Hypersensitivity: Implications for Chemical Intolerance, Chronic Fatigue, and Asthma

A Comparison of Multiple Chemical Sensitivity with Other Hypersensitivity Illnesses Suggests Evidence and a Path to Answers

Perioperative Care of Environmentally Sensitive Patients

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