Clinical characteristics of children and adolescents with thyroid disorders seen at the University of Port Harcourt Teaching Hospital: A five year review

Jaja, Tamunopriye; Yarhere, IE

doi:10.4314/njp.v41i4.2

Cited by 9 publications

(23 citation statements)

References 9 publications

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“…No child with hypothyroidism has been identified with this programme thus far. However, there are reports of CH in babies born within the study period in one of the included cities [12] but not in the collaborating hospitals. This highlights the need to improve the scale-up in all hospitals and to make the programme national rather than institutional as it is at the present time.…”

Section: Discussionmentioning

confidence: 99%

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Normative Thyroid-Stimulating Hormone Values for Healthy Nigerian Newborns

Yarhere

Jaja²,

Oduwole³

et al. 2015

Horm Res Paediatr

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Background: Congenital hypothyroidism is a common congenital endocrine disorder prevailing all over the world. No nationwide screening exists for any sub-Saharan country. We present normative cord and capillary thyroid-stimulating hormone (TSH) values for healthy Nigerian newborns. Subjects and Methods: A cross-sectional study was carried out in 6 university hospitals in Nigeria between January 1 and December 31, 2013. Cord and heel blood placed on 4 concentric circles on a Whartman filter paper were analysed for TSH within 1 week of collection using AutoDelfia 1235 immunoassay (Perkin Elmer Wallace, Boston, Mass., USA) at Charité - Universitätsmedizin Berlin, Berlin, Germany. The mean TSH levels of the newborns were determined, considering their sex, birthweight, socioeconomic status, and birth city. The association between the mean TSH level and other parameters was determined by analysis of variance. Results: A total of 2,014 subjects were recruited during the study period. The mean TSH value for the subjects was 1.86 μIU/ml, and 98.1% of the newborns were within the 2.5th and 97.5th percentiles (range: 0.09-7.90 μIU/ml) of the TSH levels. We collected 247 cord and 1,767 heel samples, respectively, and the range was slightly higher in samples from cord blood. Conclusion: The study highlights the normal reference values for capillary/cord TSH levels in term Nigerian newborns. TSH was higher in one region, attributable to earlier sampling, but was not influenced by gender, socioeconomic status, or birthweight.

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Section: Discussionmentioning

confidence: 99%

“…There is also no known nationwide study on the problem of CH in Nigeria. However, there are several studies [9,10,11,12] that have reported cases of CH in Nigerian children. For proper and evidence-based advocacy, there is a need to determine the prevalence of CH in the Nigerian population.…”

Section: Introductionmentioning

confidence: 99%

Normative Thyroid-Stimulating Hormone Values for Healthy Nigerian Newborns

Yarhere

Jaja²,

Oduwole³

et al. 2015

Horm Res Paediatr

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“…This rate is, however, higher than the incidence of 0.07% reported in a previous Nigerian study by Laditan and Johnson 4 in Ibadan, South-West Nigeria, done about 40 years ago. The higher incidence rates of the index study and other relatively recent studies 6 7 may be related to more awareness about pediatric endocrine diseases in the country due to the development of the subspecialty in Nigeria and training of more medical personnel. With regard to the extent endocrine diseases contribute to the burden of pediatric consultations, the percentage of 1.03% in the present study is slightly higher than the rates of 0.72% in Benin and 0.2% in Ibadan, both in Nigeria,.…”

Section: Discussionmentioning

confidence: 80%

“…This is comparable to the rates of 0.12% and 0.1% documented in recent reports by Onyiriuka et al . 6 and Jaja and Yarhere 7 from Benin and Port Harcourt, both in South-South Nigeria, respectively. This rate is, however, higher than the incidence of 0.07% reported in a previous Nigerian study by Laditan and Johnson 4 in Ibadan, South-West Nigeria, done about 40 years ago.…”

Section: Discussionmentioning

confidence: 99%

“…In spite of the well-recognized profound effect of thyroid dysfunction in children, there are very few studies that have examined childhood and adolescent thyroid disorders in Nigeria. 4 5 6 7 The incidence of thyroid disorders in children appears to be increasing. 6 The etiology, prevalence, clinical presentation, and clinical course of thyroid disorders in children and adolescents substantially differ from that of adults.…”

Section: Introductionmentioning

confidence: 99%

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Pattern of thyroid disorders in children and adolescents seen at the Lagos University Teaching Hospital, Nigeria, over a 10-year period

Oyenusi

Ajayi²,

Akeredolu

et al. 2017

Niger Med J

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Introduction:Thyroid disorders account for a large proportion of pediatric endocrine disorders. Untreated hypothyroidism in childhood has permanent adverse effects on physical, intellectual, and neurological development. However, few studies have reported the pattern of pediatric thyroid disorders in Nigeria.Objectives:The objective of this study was to document the pattern of thyroid disorders in children and adolescents seen at the Lagos University Teaching Hospital (LUTH) over a 10-year period.Participants and Methods:This is a retrospective descriptive study involving children with thyroid disorders seen from January 1, 2006 to December 31, 2015.Results:Seventy-one patients with thyroid disorders (0.13%) were seen out of 52,800 new cases (incidence of 1/1000 new cases) comprising 13.4% of 546 pediatric endocrine cases with a male:female ratio of 1:1.2. Median (range) age at presentation was 1.6 (0.001–14) years. Congenital hypothyroidism (CH) constituted a major proportion of cases (46.7%), with a median (range) age at presentation of 9 (1.5–24) months. Down syndrome constituted 45% of patients with CH with associated congenital heart defects in eight (53%) patients. Acquired hypothyroidism was seen in ten patients (five goitrous and five nongoitrous). Six patients had hypothyroidism associated with multiple anterior pituitary hormone deficiency. Nine patients (all females) had hyperthyroidism with confirmed Graves' disease in 5 (55.6%), with mean age at presentation being 9.4 ± 2.09 years. Other conditions were euthyroid sick syndrome (2.8%), euthyroid goiter (1.4%), and acute thyroiditis (1.4%). Eight infants of mothers on treatment for hyperthyroidism ( first seen between the 7th h of life to 2 months of age) had transient hypothyroidism while one 8-day-old had transient hyperthyroidism.Conclusion:CH was the most common disorder encountered with late age at presentation. Routine newborn screening and maintaining a high index of suspicion are advocated.

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