Clinical characteristics of children infected with SARS-CoV-2 in Italy

Jacobis, Isabella Tarissi De; Vona, Rosa; Cittadini, Camilla; Marchesi, Alessandra; Cursi, Laura; Gambardella, Lucrezia; Villani, Alberto; Straface, Elisabetta

doi:10.1186/s13052-021-01045-0

Cited by 12 publications

(10 citation statements)

References 13 publications

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“…In relation to hospital admission rates (0.35%), ICU (0%) and mortality (0%), all values were far lower, significantly, than the population averages. These data do not differ too much from other experiences already published [26][27][28][29] and reinforce the initial plan that vaccination is not a priority in these groups [30][31][32].…”

Section: Discussionsupporting

confidence: 81%

One Year of the COVID-19 Pandemic in Galicia: A Global View of Age-Group Statistics during Three Waves

Area

Lorenzo

Marcos

et al. 2021

IJERPH

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In this work we look at the past in order to analyze four key variables after one year of the COVID-19 pandemic in Galicia (NW Spain): new infected, hospital admissions, intensive care unit admissions and deceased. The analysis is presented by age group, comparing at each stage the percentage of the corresponding group with its representation in the society. The time period analyzed covers 1 March 2020 to 1 April 2021, and includes the influence of the B.1.1.7 lineage of COVID-19 which in April 2021 was behind 90% of new cases in Galicia. It is numerically shown how the pandemic affects the age groups 80+, 70+ and 60+, and therefore we give information about how the vaccination process could be scheduled and hints at why the pandemic had different effects in different territories.

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Section: Discussionsupporting

confidence: 81%

One Year of the COVID-19 Pandemic in Galicia: A Global View of Age-Group Statistics during Three Waves

Area

Lorenzo

Marcos

et al. 2021

IJERPH

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“…There are several hypotheses on the mechanisms underlying the lower susceptibility of children to COVID-19 infection than adults [ 178 , 179 ]. First, there is a lower expression of the Angiotensin-Converting Enzyme 2 (ACE2) receptor to which the virus would bind to enter cells [ 180 ].…”

Section: Factors Impacting Lower Susceptibility Of Children To Covid-...mentioning

confidence: 99%

“…Among underlying diseases, chronic lung disease was the most common followed by cardiovascular disorder and immunosuppressive disease [ 32 ]. Malnutrition, cancers and kidney diseases were also implicated [ 178 ]. Respiratory syncytial virus and Enterobacter aerogenes were implicated [ 87 , 194 ].…”

Section: Factors Impacting the Severity Of Covid-19 In Childrenmentioning

confidence: 99%

SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants era

Khemiri

Ayouni

Triki

et al. 2022

Virol J

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Background COVID-19, the coronavirus disease that emerged in December 2019, caused drastic damage worldwide. At the beginning of the pandemic, available data suggested that the infection occurs more frequently in adults than in infants. In this review, we aim to provide an overview of SARS-CoV-2 infection in children before and after B.1.617.2 Delta and B.1.1.529 Omicron variants emergence in terms of prevalence, transmission dynamics, clinical manifestations, complications and risk factors. Methods Our method is based on the literature search on PubMed, Science Direct and Google Scholar. From January 2020 to July 2022, a total of 229 references, relevant for the purpose of this review, were considered. Results The incidence of SARS-CoV-2 infection in infants was underestimated. Up to the first half of May, most of the infected children presented asymptomatic or mild manifestations. The prevalence of COVID-19 varied from country to another: the highest was reported in the United States (22.5%). COVID-19 can progress and become more severe, especially with the presence of underlying health conditions. It can also progress into Kawasaki or Multisystem Inflammatory Syndrome (MIS) manifestations, as a consequence of exacerbating immune response. With the emergence of the B.1.617.2 Delta and B.1.1.529 Omicron variants, it seems that these variants affect a large proportion of the younger population with the appearance of clinical manifestations similar to those presented by adults with important hospitalization rates. Conclusion The pediatric population constitutes a vulnerable group that requires particular attention, especially with the emergence of more virulent variants. The increase of symptomatic SARS-CoV-2 infection and hospitalization rate among children highlights the need to extend vaccination to the pediatric population.

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“…Therefore, following their research developments and trends may help us understand the forefront of pediatric COVID-19 academics. For example, researchers focused on clinically relevant research of COVID-19 in children, such as the diagnosis (25,26), clinical features (27,28), clinical management (29)(30)(31), and treatment of COVID-19 in combination with other diseases (32,33). The articles by Shao are mainly related to the differentiation of COVID-19 and other pulmonary infections in children (34)(35)(36), clinical and computed tomography features (37)(38)(39)(40), and COVID-19-related immunology studies (41)(42)(43).…”

Section: Cluster Analysis Of Abstractmentioning

confidence: 99%

Global Research Trends in Pediatric COVID-19: A Bibliometric Analysis

Wang

et al. 2022

Front. Public Health

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BackgroundCoronavirus disease 2019 (COVID-19) emerged in 2019 and has since caused a global pandemic. Since its emergence, COVID-19 has hugely impacted healthcare, including pediatrics. This study aimed to explore the current status and hotspots of pediatric COVID-19 research using bibliometric analysis.MethodsThe Institute for Scientific Information Web of Science core collection database was searched for articles on pediatric COVID-19 to identify original articles that met the criteria. The retrieval period ranged from the creation of the database to September 20, 2021. A total of 3,561 original articles written in English were selected to obtain data, such as author names, titles, source publications, number of citations, author affiliations, and countries where the studies were conducted. Microsoft Excel (Microsoft, Redmond, WA) was used to create charts related to countries, authors, and institutions. VOSviewer (Center for Science and Technology Studies, Leiden, The Netherlands) was used to create visual network diagrams of keyword, author, and country co-occurrence.ResultsWe screened 3,561 publications with a total citation frequency of 30,528. The United States had the most published articles (1188 articles) and contributed the most with author co-occurrences. The author with the most published articles was Villani from the University of Padua, Italy. He also contributed the most co-authored articles. The most productive institution was Huazhong University of Science and Technology in China. The institution with the most frequently cited published articles was Shanghai Jiao Tong University in China. The United States cooperated most with other countries. Research hotspots were divided into two clusters: social research and clinical research. Besides COVID-19 and children, the most frequent keywords were pandemic (251 times), mental health (187 times), health (172 times), impact (148 times), and multisystem inflammatory syndrome in children (MIS-C) (144 times).ConclusionPediatric COVID-19 has attracted considerable attention worldwide, leading to a considerable number of articles published over the past 2 years. The United States, China, and Italy have leading roles in pediatric COVID-19 research. The new research hotspot is gradually shifting from COVID-19 and its related clinical studies to studies of its psychological and social impacts on children.

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Clinical characteristics of children infected with SARS-CoV-2 in Italy

Cited by 12 publications

References 13 publications

One Year of the COVID-19 Pandemic in Galicia: A Global View of Age-Group Statistics during Three Waves

One Year of the COVID-19 Pandemic in Galicia: A Global View of Age-Group Statistics during Three Waves

SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants era

Global Research Trends in Pediatric COVID-19: A Bibliometric Analysis

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