Clinical characteristics of children with 2009 pandemic H1N1 influenza virus infections

Dubnov-Raz, Gal; Somech, Raz; Warschawski, Yaniv; Eisenberg, Gilad; Bujanover, Yoram

doi:10.1111/j.1442-200x.2010.03271.x

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…This finding is of particular importance when assessing the permissiveness of ocular cells to 2009 pandemic viruses. Documented instances of ocular symptoms following exposure to seasonal or 2009 H1N1 viruses are rare, suggesting that these viruses are poorly suited to use the eye as a portal of entry (19,33,44). In support of this, we demonstrated previously that seasonal and 2009 H1N1 viruses do not readily infect mice when inoculated by the ocular route and do not replicate to high titer in human corneal cells (7,8).…”

Section: Discussionmentioning

confidence: 99%

“…Highly pathogenic avian influenza (HPAI) H7 viruses frequently cause conjunctivitis in infected individuals but also possess the ability to cause severe respiratory disease and even death (21). While rare, sporadic reports of ocular-related symptoms following H5N1, seasonal, and 2009 H1N1 virus infection have also been documented (1,15,19,33,44,45). The properties which govern the ocular tropism of influenza viruses, and of H7 viruses in particular, are poorly understood.…”

mentioning

confidence: 99%

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Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Belser

Zeng

Katz

et al. 2011

J Virol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Belser

Zeng

Katz

et al. 2011

J Virol

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“…While infrequent, ocular complications have been documented following human infection with influenza virus subtypes that are more commonly associated with respiratory illness. Concomitant conjunctivitis and respiratory disease have been reported among individuals infected with or exposed to H5N1 viruses (11,(112)(113)(114), and seasonal and 2009 H1N1 influenza viruses have also sporadically caused ocular complications following human infection (12,104,115,116). The occurrence of rare adverse events following seasonal influenza virus vaccination, including the onset of oculorespiratory syndrome and the rejection of corneal transplants in vaccine recipients, underscores the importance of studying the ocular environment in the framework of influenza virus infection and vaccination (117)(118)(119)(120).…”

Section: Orthomyxovirusesmentioning

confidence: 99%

Ocular Tropism of Respiratory Viruses

Belser

Rota

Tumpey

2013

Microbiol Mol Biol Rev

323

359

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SUMMARY Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus, coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from mild influenza-like symptoms to acute respiratory failure. While species D adenoviruses and subtype H7 influenza viruses are known to possess an ocular tropism, documented human ocular disease has been reported following infection with all principal respiratory viruses. In this review, we describe the anatomical proximity and cellular receptor distribution between ocular and respiratory tissues. All major respiratory viruses and their association with human ocular disease are discussed. Research utilizing in vitro and in vivo models to study the ability of respiratory viruses to use the eye as a portal of entry as well as a primary site of virus replication is highlighted. Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism.

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“…While ocular disease is generally rare following influenza virus infection in humans, viruses within the H7 subtype have demonstrated an apparent ocular tropism, with the majority of human infections with H7 influenza viruses associated with conjunctivitis [6]. Moreover, ocular complications have been sporadically documented following seasonal, 2009 H1N1 pandemic, and avian H5N1 virus infections in humans [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Influenza Virus Respiratory Infection and Transmission Following Ocular Inoculation in Ferrets

et al. 2012

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While influenza viruses are a common respiratory pathogen, sporadic reports of conjunctivitis following human infection demonstrates the ability of this virus to cause disease outside of the respiratory tract. The ocular surface represents both a potential site of virus replication and a portal of entry for establishment of a respiratory infection. However, the properties which govern ocular tropism of influenza viruses, the mechanisms of virus spread from ocular to respiratory tissue, and the potential differences in respiratory disease initiated from different exposure routes are poorly understood. Here, we established a ferret model of ocular inoculation to explore the development of virus pathogenicity and transmissibility following influenza virus exposure by the ocular route. We found that multiple subtypes of human and avian influenza viruses mounted a productive virus infection in the upper respiratory tract of ferrets following ocular inoculation, and were additionally detected in ocular tissue during the acute phase of infection. H5N1 viruses maintained their ability for systemic spread and lethal infection following inoculation by the ocular route. Replication-independent deposition of virus inoculum from ocular to respiratory tissue was limited to the nares and upper trachea, unlike traditional intranasal inoculation which results in virus deposition in both upper and lower respiratory tract tissues. Despite high titers of replicating transmissible seasonal viruses in the upper respiratory tract of ferrets inoculated by the ocular route, virus transmissibility to naïve contacts by respiratory droplets was reduced following ocular inoculation. These data improve our understanding of the mechanisms of virus spread following ocular exposure and highlight differences in the establishment of respiratory disease and virus transmissibility following use of different inoculation volumes and routes.

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Clinical characteristics of children with 2009 pandemic H1N1 influenza virus infections

Cited by 10 publications

References 18 publications

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

Ocular Tropism of Respiratory Viruses

Influenza Virus Respiratory Infection and Transmission Following Ocular Inoculation in Ferrets

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