2020
DOI: 10.4143/crt.2019.292
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Clinical Characteristics of Clear Cell Ovarian Cancer: A Retrospective Multicenter Experience of 308 Patients in South Korea

Abstract: The purpose of this study was to evaluate clinical characteristics and treatment pattern of ovarian clear cell carcinoma (OCCC) in Korea and the role of adjuvant chemotherapy in early stage. Materials and Methods Medical records of 308 cases of from 21 institutions were reviewed and data including age, performance status, endometriosis, thromboembolism, stage, cancer antigen 125, treatment, recurrence, and death were collected. Results Regarding stage of OCCC, it was stage I in 194 (63.6%), stage II in 34 (11.… Show more

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Cited by 28 publications
(21 citation statements)
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“…10 Clear cell carcinoma is often associated with endometriosis, 11 12 and the presence of endometriosis has been associated with a good prognosis. 13 Although the molecular mechanisms underlying malignant transformation have not been elucidated fully, endometriosis, particularly ovarian endometriosis, is widely accepted as a direct precursor of endometrioid and clear cell carcinomas of the ovary. 14 15 This is supported by data showing that women with histologically proven endometriosis have a significantly elevated age-adjusted incidence rate ratio of 2.29 (95% CI 1.24 to 4.20) for clear cell carcinoma 16 and by the identification of endometriosis in the final pathology report in 51% of cases of clear cell carcinoma.…”
Section: Epidemiologymentioning
confidence: 99%
“…10 Clear cell carcinoma is often associated with endometriosis, 11 12 and the presence of endometriosis has been associated with a good prognosis. 13 Although the molecular mechanisms underlying malignant transformation have not been elucidated fully, endometriosis, particularly ovarian endometriosis, is widely accepted as a direct precursor of endometrioid and clear cell carcinomas of the ovary. 14 15 This is supported by data showing that women with histologically proven endometriosis have a significantly elevated age-adjusted incidence rate ratio of 2.29 (95% CI 1.24 to 4.20) for clear cell carcinoma 16 and by the identification of endometriosis in the final pathology report in 51% of cases of clear cell carcinoma.…”
Section: Epidemiologymentioning
confidence: 99%
“…OCCC exhibits increased activity in several signaling pathways that may drive cancer: cell cycle regulation, survival, anti-apoptosis, chemoresistance, metabolism, coagulation, and angiogenesis 7 . Based on the genomic alteration characteristics, it is possible to find some potential sources of diagnostic and prognostic biomarkers for OCCC, including hepatocyte nuclear factor 1β (HNF1β), expressed in almost all cases of OCCC without specific correlation with FIGO stage and is now used as a diagnostic marker to predict ovarian histological subtypes 33 , 99 .…”
Section: Tumor Markersmentioning
confidence: 99%
“…Patients usually present with a large, unilateral pelvic mass, and occasionally have thromboembolic vascular complications or hypercalcemia 4 , 5 . The 5-year overall survival (OS) and progression-free survival (PFS) rates are 80%~89% and 56%~88% for International Federation of Gynecology and Obstetrics (FIGO) stages I and II and decrease to 52% and 25% for stages III and IV, respectively 6 , 7 . OCCC patients at late stage tended to have poorer prognosis than those with other histological subtypes of EOC, especially in advanced EOC stages with 1.65-fold higher hazard rate for death 8 .…”
Section: Introductionmentioning
confidence: 99%
“…Patients with early-stage OCCC generally exhibit favorable prognosis, while those in advanced stage present worse survival outcomes than the high-grade serous group [3]. In addition to stage, other factors were proposed to exert in uences on the prognosis of OCCC, such as the present of endometriosis, surgical methods and venous thromboembolism [4,5]. Demographic characteristics, tumor size, lymph node status and treatment strategies are also important when evaluating survival outcomes.…”
Section: Introductionmentioning
confidence: 99%