Clinical Characteristics of Confirmed Cases of COVID-19 Admitted at Al Nahdha Hospital, Oman: A Cross-Sectional Descriptive Study

Harthi, Saud Al; Osali, Magdi Al; Ismaili, Ruwaida Al; Lawati, Sultan Al; Kamble, Bina; Shaaibi, Mustafa Al; Kindi, Nasser Al; Qasabi, Salim Al; Alhinai, Mohammed; Harthi, Hamad Al; Ghafri, Thamra S Al

doi:10.7759/cureus.17343

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Other uncommon symptoms were myalgia, difficulty in breathing, and sore throat. These findings agree with previous national [ 13 , 15 , 22 , 25 ] and an international study [ 2 ].…”

Section: Discussionsupporting

confidence: 93%

“…The mortality rate was the highest among patients over 50 years old, which is similar to studies conducted in China [ 19 ] and in Oman [ 13 , 22 ]. A British study [ 18 ] and Spanish studies [ 6 , 16 , 17 ] showed the highest mortality in older age groups ranging from 66 to 73 years.…”

Section: Discussionsupporting

confidence: 85%

“…Blood biomarkers of COVID-19 and the link with in-hospital mortality have not yet been investigated amongst patients in the northern regions of Oman. Al Harthi et al carried out a study at the central of Oman (Al Nahdha Hospital) to understand the sociodemographic, clinical, radiological, and laboratory features of the confirmed cases of COVID-19 comparing patients who required critical care and those who did not [ 13 ]. In order to further improve our understanding of the disease, this research has been conducted at Sohar Hospital, Sohar, Oman, with the aim to identify significant laboratory investigations that could play a role in early severity prediction of COVID-19 and the possibility to correlate with mortality.…”

Section: Introductionmentioning

confidence: 99%

“…Other less common symptoms were sputum production (28% of patients), headache (8% of patients), hemoptysis (5% of patients), and diarrhea (3% of patients) [2]. [13].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological, Clinical, and Laboratory Findings of 235 Hospitalized COVID-19 Adult Patients (Survivors and Non-Survivors) at Sohar Hospital in Oman

Al Khan,

Al Balushi,

Al Maqbali

et al. 2023

Cureus

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Objectives: The aim of this study was to describe the epidemiological and clinical characteristics and laboratory findings of coronavirus disease 2019 (COVID-19) patients at the Sohar Hospital, Sohar, Oman. Methods: This retrospective study of admitted COVID-19 patients at Sohar Hospital in Oman was carried out from March to October 2020. Demographics and laboratory data of 19 tests for 235 COVID-19 patients, of which 202 were survivors and 33 were non-survivors, were collected from the hospital information system after ethics approval. Results: Thirteen factors were significantly correlated with in-hospital mortality, including older age, having chronic disease, high neutrophil count, high troponin T, high creatinine, low albumin (p < 0.0001), high white blood cell (WBC) count, low hemoglobin, high D-dimer (p < 0.001), high C-reactive protein (CRP) (p < 0.002), low lymphocyte count (p < 0.003), high alkaline phosphatase (ALP) enzyme (p < 0.007) and high ferritin (p < 0.045). The most common laboratory blood test abnormalities that were highly correlated with mortality were increased values of CRP (100% of non-survivors), D-dimer (94.1% of non-survivors), ferritin (88.2% of non-survivors), and troponin T (85% of non-survivors) and reduced lymphocyte count (73.9% of non-survivors). Conclusion: These findings could help in categorizing COVID-19 patients for risk-based assessment and early identification of patients with poor prognosis.

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“…Other uncommon symptoms were myalgia, difficulty in breathing, and sore throat. These findings agree with previous national [ 13 , 15 , 22 , 25 ] and an international study [ 2 ].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

“…Other less common symptoms were sputum production (28% of patients), headache (8% of patients), hemoptysis (5% of patients), and diarrhea (3% of patients) [2]. [13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological, Clinical, and Laboratory Findings of 235 Hospitalized COVID-19 Adult Patients (Survivors and Non-Survivors) at Sohar Hospital in Oman

Al Khan,

Al Balushi,

Al Maqbali

et al. 2023

Cureus

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“…These 40 studies (reporting on 43 cohorts) were subjected to a meta-analysis (Table ). Fifteen studies reported anosmia prevalence in 18 cohorts with a total of 7247 COVID-19 patients from regions where the D614 virus was dominant: three studies from Kuwait or Singapore − and 12 from India or Pakistan. − We compared such data with the results obtained in 25 studies reporting on 25 cohorts with a total of 9626 South Asian patients from the Indian subcontinent (India and Bangladesh) and Oman, when the G614 virus had become dominant (Table , illustrated in Figure A and B). ,− The differences in results between the two types of cohorts are shown in the forest plots (Figure A). The pooled prevalence of olfactory dysfunction in the same ethnicity (South Asians) in regions with D614 predominance was 5.33% (95% confidence interval, CI = 3.52–8.00%), while in regions with G614 predominance, it was 31.79% (95% CI = 23.26–41.76%) (Figure A, C).…”

Section: Resultsmentioning

confidence: 99%

The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia

Bartheld

Hagen

Butowt

2021

ACS Chem. Neurosci.

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The prevalence of chemosensory dysfunction in patients with COVID-19 varies greatly between populations. It is unclear whether such differences are due to factors at the level of the human host, or at the level of the coronavirus, or both. At the host level, the entry proteins which allow virus binding and entry have variants with distinct properties, and the frequency of such variants differs between ethnicities. At the level of the virus, the D614G mutation enhances virus entry to the host cell. Since the two virus strains (D614 and G614) coexisted in the first six months of the pandemic in most populations, it has been difficult to distinguish between contributions of the virus and contributions of the host for anosmia. To answer this question, we conducted a systematic review and meta-analysis of studies in South Asian populations when either the D614 or the G614 virus was dominant. We show that populations infected predominantly with the G614 virus had a much higher prevalence of anosmia (pooled prevalence of 31.8%) compared with the same ethnic populations infected mostly with the D614 virus strain (pooled anosmia prevalence of 5.3%). We conclude that the D614G mutation is a major contributing factor that increases the prevalence of anosmia in COVID-19, and that this enhanced effect on olfaction constitutes a previously unrecognized phenotype of the D614G mutation. The new virus strains that have additional mutations on the background of the D614G mutation can be expected to cause a similarly increased prevalence of chemosensory dysfunctions.

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Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis

et al. 2021

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Clinical Characteristics of Confirmed Cases of COVID-19 Admitted at Al Nahdha Hospital, Oman: A Cross-Sectional Descriptive Study

Cited by 4 publications

References 23 publications

Epidemiological, Clinical, and Laboratory Findings of 235 Hospitalized COVID-19 Adult Patients (Survivors and Non-Survivors) at Sohar Hospital in Oman

Epidemiological, Clinical, and Laboratory Findings of 235 Hospitalized COVID-19 Adult Patients (Survivors and Non-Survivors) at Sohar Hospital in Oman

The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia

Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis

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