Clinical characteristics of COVID-19 and its comparison with influenza pneumonia

Qu, Jia-Jia; Chang, Lap Kam; Tang, Xiaolin; Du, Yiqun; Yang, Xi; Liu, Xiangjiao; Han, Ping; Xue, Yingwei

doi:10.1080/17843286.2020.1798668

Cited by 37 publications

(37 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The median age of COVID-19 patients in our study was lower than in recent multi-center cohort studies of patients hospitalized with SARS-CoV-2 infection in Germany that observed a mean age of 68-70 years 36,37 and with a recent cohort study analyzing electronic healthcare databases of the US Department of Veterans Affairs that observed a mean age of 69 years 19 . However, our observation that patients with SARS-CoV-2 infection are generally younger than seasonal influenza patients is consistent with previously published data 14,15,18 . Interestingly, among patients that were admitted to the ICU, age did not significantly differ between the two groups.…”

Section: Discussionsupporting

confidence: 93%

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

Brehm

Meirschen

Hennigs

et al. 2021

Sci Rep

View full text Add to dashboard Cite

While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with COVID-19 diagnosed between February 27 and June 14, 2020, and 255 patients with seasonal influenza diagnosed during the 2017–18 season at the same hospital to describe common features and differences in clinical characteristics and course of disease. Patients with COVID-19 were younger (median age [IQR], 59 [45–71] vs 66 [52–77]; P < 0001) and had fewer comorbidities at baseline with a lower mean overall age-adjusted Charlson Comorbidity Index (mean [SD], 3.0 [2.6] vs 4.0 [2.7]; P < 0.001) than patients with seasonal influenza. COVID-19 patients had a longer duration of hospitalization (mean [SD], 25.9 days [26.6 days] vs 17.2 days [21.0 days]; P = 0.002), a more frequent need for oxygen therapy (101 [60.8%] vs 103 [40.4%]; P < 0.001) and invasive ventilation (52 [31.3%] vs 32 [12.5%]; P < 0.001) and were more frequently admitted to the intensive care unit (70 [42.2%] vs 51 [20.0%]; P < 0.001) than seasonal influenza patients. Among immunocompromised patients, those in the COVID-19 group had a higher hospital mortality compared to those in the seasonal influenza group (13 [33.3%] vs 8 [11.6%], P = 0.01). In conclusion, we show that COVID-19 patients were younger and had fewer baseline comorbidities than seasonal influenza patients but were at increased risk for severe illness. The high mortality observed in immunocompromised COVID-19 patients emphasizes the importance of protecting these patient groups from SARS-CoV-2 infection.

show abstract

Section: Discussionsupporting

confidence: 93%

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

Brehm

Meirschen

Hennigs

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Among laboratory findings, leukocytosis and leukopenia were predominant in patients with influenza-associated and COVID-19-associated pneumonia, respectively. This was in line with prior studies that reported frequently ob-served leukopenia and anosmia in patients with COVID-19 infection [22,26]. These findings suggest that a thorough review of the clinical presentations and laboratory findings of each patient could give diagnostic clues for differentiating COVID-19 and influenza among patients with respiratory symptoms.…”

Section: Discussionsupporting

confidence: 90%

Differences in Clinical Characteristics and Chest Images between Coronavirus Disease 2019 and Influenza-Associated Pneumonia

Kim

Lim

et al. 2021

Diagnostics

View full text Add to dashboard Cite

Background: Concerns are arising about the simultaneous occurrence of the coronavirus disease 2019 (COVID-19) pandemic and the influenza epidemic, the so-called “twindemic”. In this study, we compared clinical characteristics and chest images from patients with COVID-19 and influenza. Methods: We conducted a case-control study of COVID-19 and age- and sex-matched influenza patients. Clinical characteristics and chest imaging findings between patients with COVID-19 and matched influenza patient controls were compared. Results: A total of 47 patients were enrolled in each group. Anosmia (14.9%) and ageusia (21.3%) were only observed in COVID-19 patients. There were 31 (66%) and 23 (48.9%) patients with COVID-19 and influenza who had pulmonary lesions confirmed by chest computed tomography (CT), respectively. The interval between symptom onset and pneumonia was significantly longer in patients with COVID-19. Round opacities were more common in images from COVID-19 patients (41.9% vs. 8.7%, p = 0.007), whereas pure consolidation (0% vs. 34.9%, p < 0.001) and pleural effusion (0% vs. 17.4%, p = 0.028) were more common in images from influenza patients. Notably, the difference in the number of involved pulmonary lobes observed on CT and pulmonary fields observed on radiographic images was significantly higher in COVID-19-associated pneumonia than that in influenza-associated pneumonia (2.32 ± 1.14 vs. 1.48 ± 0.99, p = 0.010). Conclusions: Chest images and thorough review of clinical findings could provide value for proper differential diagnoses of COVID-19 patients, but they are not sufficiently sensitive for initial diagnoses. In addition, chest radiography could underestimate COVID-19 lung involvement because of the lesion characteristics of COVID-19-associated pneumonia.

show abstract

“…Reviewing the literature we found few small -scale studies comparing laboratory parameters of adult patients with COVID- 19 and In uenza 32,42,43 and none compared with RSV. Only two studies investigated the NLR levels in COVID-19 compared to In uenza.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Prozan¹,

Shusterman²,

Ablin³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: A high Neutrophil to Lymphocyte Ratio (NLR) is considered an unfavorable prognostic factor in various diseases, including COVID-19. The prognostic value of NLR in other respiratory viral infections, such as Influenza, has not hitherto been extensively studied. We aimed to compare the prognostic value of NLR in COVID-19, Influenza and Respiratory Syncytial Virus infection (RSV).Method: A retrospective cohort of COVID-19, Influenza and RSV patients admitted to the Tel Aviv Medical Center from January 2010 to October 2020 was analyzed. Laboratory, demographic, and clinical parameters were collected. Two way analyses of variance (ANOVA) was used to compare the association between NLR values and poor outcomes among the three groups. ROC curve analyses for each virus was applied to test the discrimination ability of NLR. Results: 722 COVID-19, 2213 influenza and 482 RSV patients were included. Above the age of 50, NLR at admission was significantly lower among COVID-19 patients (P<0.001). NLR was associated with poor clinical outcome only in the COVID-19 group. ROC curve analysis was performed; the area under curve of poor outcomes for COVID-19 was 0.643, compared with 0.497 and 0.537 for Influenza and RSV respectively. In the COVID-19 group, multivariate logistic regression identified a high NLR (defined as a value above 4.7) to be a prognostic factor for poor clinical outcome, after adjusting for age, sex and Charlson comorbidity score (odds ratio of 1.6, P=0.005). Conclusions: NLR at admission is lower and has more prognostic value in COVID-19 patients, when compared to Influenza and RSV.

show abstract

Clinical characteristics of COVID-19 and its comparison with influenza pneumonia

Cited by 37 publications

References 27 publications

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

Differences in Clinical Characteristics and Chest Images between Coronavirus Disease 2019 and Influenza-Associated Pneumonia

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Contact Info

Product

Resources

About