Clinical characteristics of COVID-19 infection in chronic obstructive pulmonary disease: a multicenter, retrospective, observational study

Wu, Fan; Zhou, Yumin; Wang, Zhongfang; Xie, Min; Shi, Zhe; Tang, Zhongbin; Li, Xiaohe; Li, Xiaochen; Lei, Chunliang; Li, Yimin; Ni, Zhengyi; Hu, Yu; Liu, Xiaoqing; Yin, Wenguang; Cheng, Linling; Ye, Feng; Peng, Jieqi; Huang, Lingmei; Tian, Jia; Zhang, Lingjuan; Mo, Xiaoneng; Zhang, Ying; Hu, Ke; Jiang, Yongliang; Guan, Weijun; Xiang, Jie; Liu, Yingxia; Peng, Yuchen; Li, Wei; Hu, Yahua; Peng, Peng; Wang, Jianming; Liu, Jiyang; Huang, Wei; Chen, Ruchong; Zhao, Jianping; Li, Shiyue; Zhang, Nuofu; Zhao, Jincun; Zhong, Nanshan; Ran, Pixin

doi:10.21037/jtd-20-1914

Cited by 64 publications

(73 citation statements)

References 21 publications

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“…Extensive studies have suggested that COVID-19 patients with any comorbidity were more likely to develop severe organ injury related to pre-existing diseases. A retrospective cohort study of 3,069 hospitalized patients with COVID-19 in US demonstrated that patients with cardiovascular disease (CVD) were more likely to have myocardial injury than patients without [23]. In addition, patients with pre-existing renal diseases were more susceptible to develop renal complications induced by COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, compared with COVID-19 patients without chronic obstructive pulmonary disease (COPD), patients with COPD were more likely to develop pulmonary bacterial or fungal coinfection (20.0% vs . 5.9%), ARDS (20.0% vs. 7.3%), and septic shock (14.0% vs. 2.3%) [ 23 ]. In addition, patients with pre-existing renal diseases were more susceptible to develop renal complications induced by COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

et al. 2020

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Background Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40–59 years) patients without comorbidities is scarce. Methods We therefore conducted this multicentre retrospective study and collected data of middle-aged COVID-19 patients without comorbidities at admission from three designated hospitals in China. Results Among 119 middle-aged patients without comorbidities, 18 (15.1%) developed into severe illness and 5 (3.9%) died in hospital. ARDS (26, 21.8%) and elevated D-dimer (36, 31.3%) were the most common complications, while other organ complications were relatively rare. Multivariable regression showed increasing odds of severe illness associated with neutrophil to lymphocyte ratio (NLR, OR, 11.238; 95% CI 1.110–1.382; p < 0.001) and D-dimer greater than 1 µg/ml (OR, 16.079; 95% CI 3.162–81.775; p = 0.001) on admission. The AUCs for the NLR, D-dimer greater than 1 µg/ml and combined NLR and D-dimer index were 0.862 (95% CI, 0.751–0.973), 0.800 (95% CI 0.684–0.915) and 0.916 (95% CI, 0.855–0.977), respectively. SOFA yielded an AUC of 0.750 (95% CI 0.602–0.987). There was significant difference in the AUC between SOFA and combined index (z = 2.574, p = 0.010). Conclusions More attention should be paid to the monitoring and early treatment of respiratory and coagulation abnormalities in middle-aged COVID-19 patients without comorbidities. In addition, the combined NLR and D-dimer higher than 1 μg/ml index might be a potential and reliable predictor for the incidence of severe illness in this specific patient with COVID-19, which could guide clinicians on early classification and management of patients, thereby relieving the shortage of medical resource. However, it is warranted to validate the reliability of the predictor in larger sample COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

et al. 2020

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“…Extracorporeal blood purification with continuous renal replacement therapy (CRRT), as the most common technique in clinical practice, played an important role in the rescue of SARS, MERS and other sepsis-associated AKI 92 . Approximately 0.4-2.3% of COVID-19 patients required CRRT, with AKI as the main reason 6 , 12 , 93 . The proportion increased to 5.6-23.0% in critically ill patients in the ICU 2 , 3 , 7 , 10 , 71 .…”

Section: Treatment Of Covid-19-associated Acute Kidney Injurymentioning

confidence: 99%

Acute Kidney Injury in COVID-19: The Chinese Experience

Zheng

Zhao

2020

Seminars in Nephrology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…COPD up-regulated ACE-2 expression in lower airways, which in part may explain the increased risk of severe COVID-19 or mortality in patients with COVID-19 and COPD 7 . Previously studies showed a worse outcomes in patients with COVID-19 and COPD compared with those without COPD, while did not descript the risk factors for mortality in these population 8,9 . Additionally, a proportion of COPD infected COVID-19 will treat their illness at home probably under the pandemic of COVID-19 10 .…”

Section: Introductionmentioning

confidence: 85%

Clinical characteristics and risk factors for mortality in patients with COVID-19 and chronic obstructive pulmonary disease in Wuhan, China

Zeng

Huang

Liu

et al. 2020

Preprint

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Patients with COVID-19 and COPD are at high risks. However, the risk factors for mortality in COPD patients infected COVID-19 are limited. In this retrospective study, consecutive COPD cases infected COVID-19 in East District of People's Hospital of Wuhan University from Jan 11th 2020 to Mar 28th 2020 were included. Different outcomes were compared between dead and discharged patients. Cox regression analysis was performed to explore the risk factors for death. Totally, 52 cases were included (aged 64.0-79.0 years, 39 [75.0%] males). Common symptoms on admission were cough (43, 82.6%), fever (41, 78.8%) and expectoration (21, 40.3%). Thirty-eight (73.1%) patients were discharged, and 14 (26.9%) cases were dead which mainly caused by multiple organ failure (7, 50.0%) and respiratory failure (6, 42.9%). Multivariate analysis indicated that age > 70 years (HR, 7.859, 95% CI: 1.376, 44.875; P = 0.020) and count of lymphocyte ≤ 0.8×109/L (HR, 27.429, 95% CI: 3.336, 225.530; P = 0.002) were risk factors for death. The study showed that close monitoring of the risk indexes is important for early supportive care during the management of patients with COVID-19 and COPD.

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Clinical characteristics of COVID-19 infection in chronic obstructive pulmonary disease: a multicenter, retrospective, observational study

Cited by 64 publications

References 21 publications

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study

Acute Kidney Injury in COVID-19: The Chinese Experience

Clinical characteristics and risk factors for mortality in patients with COVID-19 and chronic obstructive pulmonary disease in Wuhan, China

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