Clinical Characteristics of COVID-19 Patients with Gastrointestinal Symptoms

Montazeri, Mahnaz; Maghbouli, Nastaran; Jamali, Raika; Sharifi, Amirsina; Pazoki, Marzieh; Salimzadeh, Ahmad; Barzegari, Behnaz; Rafiei, Najme; Mansouri, Ensieh Sadat; Hadadi, Azar

doi:10.34172/aim.2021.21

Cited by 13 publications

(12 citation statements)

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“…In addition, there was not a relationship between respiratory symptoms and GI manifestations in the study. 30 In line with these studies, Zhang et al 31 investigated the clinical characteristics of COVID-19 patients with GI symptoms from Wuhan in early 2020. They reported that 164 patients (32.5%) experienced GI symptoms, including appetence, diarrhea, nausea, abdominal pain, and vomiting.…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Post-infectious Irritable Bowel Syndrome, Anxiety, and Depression in Iranian Patients with Coronavirus Disease 2019 Pandemic: A Cross-Sectional Study

Farsi¹,

Zonooz²,

Ebrahimi³

et al. 2022

Turk J Gastroenterol

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Background: Irritable bowel syndrome refers to a subgroup of disorders of gut–brain interaction associated with stress-related symptoms, but gastrointestinal infection can also be considered the leading risk factor. It is well reported that coronavirus disease 2019 can also result in gastroenteritis. Therefore, this study aimed to evaluate the incidence of post-infectious irritable bowel syndrome and stressful status among coronavirus disease 2019 patients. Methods: This cross-sectional study was conducted on adults with coronavirus disease 2019 referred to the Infectious Disease Clinic in Iran from November 2020 to February 2021. Patients who met all eligibility criteria were included in the study. The data were collected using a demographic questionnaire, Rome IV criteria questionnaire, and Hospital Anxiety and Depression Scale. Results: Totally, the data obtained from 233 eligible patients (136 women, 97 men; mean age 38.41) 11.52 (years) were collected and analyzed, and 53.2% of the cases had a moderate coronavirus disease 2019. The analysis showed that 27 (11.6%) patients suffered from irritable bowel syndrome symptoms based on Rome IV criteria after the recovery from the infection. Also, Hospital Anxiety and Depression Scale-based symptoms of depression and anxiety that occurred with coronavirus disease 2019 were reported in 27.4% and 36.9%, respectively. Conclusion: Our finding illustrated that irritable bowel syndrome symptoms based on Rome IV could occur in post-infected coronavirus disease 2019 patients. Also, Hospital Anxiety and Depression Scale-based symptoms of depression and anxiety were more common in females and coronavirus disease 2019 infected patients with clinical symptoms including cough, shortness of breath, and sore throat.

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Section: Discussionmentioning

confidence: 99%

The Incidence of Post-infectious Irritable Bowel Syndrome, Anxiety, and Depression in Iranian Patients with Coronavirus Disease 2019 Pandemic: A Cross-Sectional Study

Farsi¹,

Zonooz²,

Ebrahimi³

et al. 2022

Turk J Gastroenterol

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“…Our study showed that patients with isolated GI symptoms who test positive for PCR were less likely to be admitted to the ICU (95% CI: 0.174-0.987, P: 0.047). While studies by Montazeri et al (20) and Buscarini et al (21) did not find any relationship between the GI symptoms and ICU admission possibility. It might be due to the differences in the grouping of patients as these studies have categorized patients into GI and non-GI groups.…”

Section: Resultsmentioning

confidence: 76%

Untitled

2022

J. Med. Chem. Sci.

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Background: While classic symptoms of coronavirus disease 2019 (COVID-19) are well known, monitoring symptoms with less frequency is critical for controlling COVID-19 transmission. Objectives: This study aimed to evaluate the association of gastrointestinal (GI) symptoms with nasal swab Polymerase Chain Reaction (PCR) test positivity and high-resolution CT (HRCT) findings in favor of COVID-19 in patients suspected of COVID-19 in Jahrom city. Methods: This cross-sectional study was performed on 2519 COVID-19 suspected patients in Peymaniyeh Hospital, Jahrom city, from January 2020 to July 2020. In addition to nasal swab PCR test, diagnostic data, various clinical symptoms, and demographic data were gathered. Patients were categorized as having GI symptoms alone or with other COVID-19 symptoms or not having GI symptoms. Data were analyzed using logistic regression and Mantel-Cox log-rank analysis.Results: There were 59 patients with isolated GI symptoms, 1694 without any GI symptoms, and 766 patients with GI symptoms along with other symptoms. The average hospitalization length of patients without GI symptoms was significantly higher than the other two groups (P< 0.001). The abnormal HRCT results were significantly higher among patients with Isolated GI symptoms (P<0.001). Patients without GI symptoms were 1.7 (95% CI: 1.003-2.908, P: 0.049) times more likely to test positive for COVID-19 than those with isolated GI symptoms. Patients with isolated GI symptoms were less likely to be admitted to the ICU (95% CI: 0.174-0.987, P: 0.047). Conclusions: Our study demonstrated distinct clinical outcomes in COVID-19 patients based on the presence of GI symptoms. While patients who had isolated GI symptoms had more probability of lung involvement in CT scan results, the probability of being admitted to ICU is less likely in them.

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“…And OR values were < 1 in 7 [ 15 , 19 , 33 , 34 , 37 , 46 , 49 ] of these 8 literatures. On the other hand, 7 [ 12 , 16 , 18 , 25 , 29 , 36 , 57 ] of 13 Asian studies [ 12 , 16 , 18 , 25 , 29 , 30 , 36 , 38 , 40 , 43 , 50 , 52 , 57 ] reported that patients with GI symptoms were older, and OR values were > 1 in 6[ 12 , 16 , 25 , 29 , 36 , 57 ] of these 7 studies. It turns out that the studies carried out in different locations vary in the characteristics of included patients, especially in the age of patients with/without GI symptoms.…”

Section: Resultsmentioning

confidence: 99%

Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis

Wang

Zhang

et al. 2022

BMC Gastroenterol

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Background Gastrointestinal symptoms have been reported in patients with COVID-19. Several clinical investigations suggested that gastrointestinal symptoms were associated with disease severity of COVID-19. However, the relevance of gastrointestinal symptoms and mortality of COVID-19 remains largely unknown. We aim to investigate the relationship between gastrointestinal symptoms and COVID-19 mortality. Methods We searched the PubMed, Embase, Web of science and Cochrane for studies published between Dec 1, 2019 and May 1, 2021, that had data on gastrointestinal symptoms in COVID-19 patients. Additional literatures were obtained by screening the citations of included studies and recent reviews. Only studies that reported the mortality of COVID-19 patients with/without gastrointestinal symptoms were included. Raw data were pooled to calculate OR (Odds Ratio). The mortality was compared between patients with and without gastrointestinal symptoms, as well as between patients with and without individual symptoms (diarrhea, nausea/vomiting, abdominal pain). Results Fifty-three literatures with 55,245 COVID-19 patients (4955 non-survivors and 50,290 survivors) were included. The presence of GI symptoms was not associated with the mortality of COVID-19 patients (OR=0.88; 95% CI 0.71–1.09; P=0.23). As for individual symptoms, diarrhea (OR=1.01; 95% CI 0.72–1.41; P=0.96), nausea/vomiting (OR=1.16; 95% CI 0.78–1.71; P=0.46) and abdominal pain (OR=1.55; 95% CI 0.68–3.54; P=0.3) also showed non-relevance with the death of COVID-19 patients. Conclusions Gastrointestinal symptoms are not associated with higher mortality of COVID-19 patients. The prognostic value of gastrointestinal symptoms in COVID-19 requires further investigation.

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Clinical Characteristics of COVID-19 Patients with Gastrointestinal Symptoms

Cited by 13 publications

References 0 publications

The Incidence of Post-infectious Irritable Bowel Syndrome, Anxiety, and Depression in Iranian Patients with Coronavirus Disease 2019 Pandemic: A Cross-Sectional Study

The Incidence of Post-infectious Irritable Bowel Syndrome, Anxiety, and Depression in Iranian Patients with Coronavirus Disease 2019 Pandemic: A Cross-Sectional Study

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Are gastrointestinal symptoms associated with higher risk of Mortality in COVID-19 patients? A systematic review and meta-analysis

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