Clinical Characteristics of COVID-19 Related Deaths in Ethiopia

Sultan, Menbeu; Kene, Desalegn; Waganew, Woldesenbet; Worku, Aschalew; Azazh, Aklilu; Girma, Beza; Seman, Yakob; Tessema, Natinael; Yifru, Sisay; Teklu, Sisay; Argaw, Rahel; Tefera, Molla; Walelegn, Miraf; Redae, Berhane

doi:10.4314/ejhs.v31i2.3

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…On average, 121 new illnesses were recorded each day, that is much lower than the highest daily average ever recorded since the outbreak started. Since the start of the pandemic, there have been 468,345 illnesses and 7,438 deaths attributed to the coronavirus throughout the nation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Magnitude and associated factors of mortality among patients admitted with COVID-19 in Addis Ababa, Ethiopia

Getahun,

Dinku,

Jara

et al. 2023

PLOS Glob Public Health

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The COVID-19 pandemic continues to grow around the world and has caused enormous mortality and morbidity. The severity and mortality of coronavirus disease are associated with various comorbidities. The infection fatality rate was reported to be inconsistent with different studies. Therefore, the aim of this study was to assess the magnitude and factors associated with mortality among patients admitted to Eka Kotebe General Hospital, Addis Ababa, Ethiopia. An institutional-based cross-sectional study was conducted at Eka Kotebe General Hospital among patients who were admitted for COVID-19 from January 15, 2021, to June 30, 2021. A total of 393 records of patients were selected by simple random sampling. Data was extracted from compiled data forms where available information was already tabulated. Data was entered and analyzed using SPSS version 25. The determinant factors associated with mortality among COVID-19 patients were identified using bivariate and multivariable logistic regression analysis. A statistical association was declared with multivariable logistic regression using a 95% confidence interval and a P-value of less than 0.05. The proportion of COVID-19 mortality among patients admitted to Eka Kotebe General Hospital was 8.1% (95% CI (5.4–10.8%)). Age >50 years [AOR = 7.91; 95% CI (2.34–25.70)], being male [AOR = 2.09; 95% CI (1.20–3.65)], having diabetes mellitus [AOR = 2.64; 95% CI (1.30–5.35)], having hypertension [AOR = 2.67; 95% CI (1.22–5.88)] and having chronic kidney disease [AOR = 12.04; 95% CI (4.03–14.22)] were determinant factors of COVID-19 mortality. The current study findings revealed that COVID-19 mortality was high among hospitalized COVID-19 patients. Furthermore, age, gender, diabetes mellitus, hypertension, and chronic kidney disease were discovered to be independent predictors of COVID-19 mortality. Therefore, older COVID-19 patients and those with established comorbidities such as hypertension, diabetes, and end-stage renal disease should receive comprehensive preventative efforts, including vaccination.

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Section: Introductionmentioning

confidence: 99%

Magnitude and associated factors of mortality among patients admitted with COVID-19 in Addis Ababa, Ethiopia

Getahun,

Dinku,

Jara

et al. 2023

PLOS Glob Public Health

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“…Nine further studies reported descriptive statistics on COVID-19 mortality and hypertension or CVD but did not calculate statistics to formally compare groups. 15,24,26,29,35–39…”

Section: Resultsmentioning

confidence: 99%

“…34 Nine further studies reported descriptive statistics on COVID-19 mortality and hypertension or CVD but did not calculate statistics to formally compare groups. 15,24,26,29,[35][36][37][38][39] Influence of COVID-19 Infection on CVD Two small studies examined the impact of the COVID-19 pandemic on incident CVD and CVD mortality. 30,40 In an observational comparison of stroke admissions before (n=401) and after (n=431) the COVID-19 pandemic in a hospital in Ghana, the stroke admission rate was +7.5% higher in the COVID-19 era (95% CI, 5.1%-10.5%), but the stroke mortality rate was similar (aOR, 1.2 [95% CI, 0.9-1.7]).…”

Section: Covid-19 Mortalitymentioning

confidence: 99%

Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review

et al. 2022

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Background: Sub-Saharan Africa (SSA) has the highest age-adjusted burden of hypertension and cardiovascular disease (CVD). SSA also experiences many viral infections due to unique environmental and societal factors. The purpose of this narrative review is to examine evidence around how hypertension, CVD, and emerging viral infections interact in SSA. Methods: In September 2021, we conducted a search in MEDLINE, Embase, and Scopus, limited to English language studies published since 1990, and found a total of 1169 articles. Forty-seven original studies were included, with 32 on COVID-19 and 15 on other emerging viruses. Results: Seven articles, including those with the largest sample size and most robust study design, found an association between preexisting hypertension or CVD and COVID-19 severity or death. Ten smaller studies found no association, and 17 did not calculate statistics to compare groups. Two studies assessed the impact of COVID-19 on incident CVD, with one finding an increase in stroke admissions. For other emerging viruses, 3 studies did not find an association between preexisting hypertension or CVD on West Nile and Lassa fever mortality. Twelve studies examined other emerging viral infections and incident CVD, with 4 finding no association and 8 not calculating statistics. Conclusions: Growing evidence from COVID-19 suggests viruses, hypertension, and CVD interact on multiple levels in SSA, but research gaps remain especially for other emerging viral infections. SSA can and must play a leading role in the study and control of emerging viral infections, with expansion of research and public health infrastructure to address these interactions.

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“…Finally, eleven articles were retrieved and included with a total sample size of 2845 populations. Of these studies, three of them were in China [37][38][39], three in Ethiopia [21,40,41], two in the USA [42,43], One in Pakistan [44], one in South Africa [45], and one in South Sudan [46]. The prevalence of COVID-19-induced ARDS ranges from 9 [40] to 67.3% [39].…”

Section: Study Selection and Characteristics Of The Studiesmentioning

confidence: 99%

Global prevalence of COVID-19-induced acute respiratory distress syndrome: systematic review and meta-analysis

Azagew,

Beko,

Ferede

et al. 2023

Syst Rev

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Background Acute respiratory distress syndrome (ARDS) is potentially a fatal form of respiratory failure among COVID-19 patients. Globally, there are inconsistent findings regarding ARDS among COVID-19 patients. Therefore, this study aimed to estimate the pooled prevalence of COVID-19-induced ARDS among COVID-19 patients worldwide. Methods To retrieve relevant studies, the authors searched Embase, MEDLINE, PubMed, Web of Science, Cochrane Library, Google, and Google Scholar using a combination of search terms. The search was conducted for articles published from December 2019 to September 2022. Articles were searched and screened by title (ti), abstract (ab), and full-text (ft) by two reviewers independently. The quality of each included article was assessed using the Newcastle–Ottawa Assessment Scale. Data were entered into Microsoft Word and exported to Stata version 14 for analysis. Heterogeneity was detected using the Cochrane Q statistics and I-square (I2). Then the sources of variations were identified by subgroup and meta-regression analysis. A random effect meta-analysis model was used. The publication bias was detected using the graphic asymmetry test of the funnel plot and/or Egger’s test (p value < 0.05). To treat the potential publication bias, trim and fill analysis were computed. The protocol has been registered in an international database, the Prospective Register of Systematic Reviews (PROSPERO) with reference number: CRD42023438277. Results A total of 794 studies worldwide were screened for their eligibility. Of these 11 studies with 2845 participants were included in this systematic review and meta-analysis. The overall pooled prevalence of COVID-19-induced ARDS in the world was found to be 32.2% (95%CI = 27.70–41.73%), I2 = 97.3%, and p value < 0.001). Conclusion The pooled prevalence of COVID-19-induced ARDS was found to be high. The virus remains a global burden because its genetic causes are constantly changing or it mutated throughout the pandemic to emerge a new strain of infection. Therefore, interventions such as massive vaccination, early case detection, screening, isolation, and treatment of the cases need to be implemented to tackle its severity.

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Clinical Characteristics of COVID-19 Related Deaths in Ethiopia

Cited by 9 publications

References 14 publications

Magnitude and associated factors of mortality among patients admitted with COVID-19 in Addis Ababa, Ethiopia

Magnitude and associated factors of mortality among patients admitted with COVID-19 in Addis Ababa, Ethiopia

Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review

Global prevalence of COVID-19-induced acute respiratory distress syndrome: systematic review and meta-analysis

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