Clinical characteristics of critically ill patients with COVID-19

Abstract

ObjectiveDescribe the clinical and respiratory characteristics of critical patients with coronavirus disease 2019 (COVID-19).DesignObservational and retrospective study over 6 months.SettingIntensive care unit (ICU) of a high complexity hospital in Buenos Aires, Argentina.PatientsPatients older than 18 years with laboratory-confirmed COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV-2 were included in the study.Variables of interestDemographic characteristics such as sex and age, comorbidities, laboratory results, imaging results, ventilatory mechanics data, complications, and mortality were recorded.ResultsA total of 168 critically ill patients with COVID-19 were included. 66% were men with a median age of 65 years (58-75. 79.7% had at least one comorbidity. The most frequent comorbidity was arterial hypertension, affecting 52.4% of the patients. 67.9 % required invasive mechanical ventilation (MV), and no patient was treated with non-invasive ventilation. Most of the patients in MV (73.7%) required neuromuscular blockade due to severe hypoxemia. 36% of patients were ventilated in the prone position. The length of stay in the ICU was 13 days (6-24) and the mortality in the ICU was 25%.ConclusionsIn this study of critical patients infected by SARS-CoV-2 in a high-complexity hospital, the majority were comorbid elderly men, a large percentage required invasive mechanical ventilation, and ICU mortality was 25%.

The influence of social isolation on the incidence of positivity in covid-19 tests in a metropolitan region of São Paulo, Brazil

“…The average age was 42 years for women and 45 years for men. The average age was similar to the averages observed in India 20 and Peru 21 and lower than the averages observed in China 22 , Europe 23 , Argentina 24 and Australia 25 . The age averages are compatible with the age of the economically active population of the assessed municipalities.…”

The Impact of Neutrophil-Lymphocyte Count Ratio in COVID-19: A Systematic Review and Meta-Analysis

“…A total of 90 studies (82 retrospectives, 5 prospective, 3 cross-sectional) out of 7352 identified publications were included after satisfying the inclusion criteria (Figure 1). While 44 articles 41,42,44,46,47,49,[73][74][75][76][78][79][80]101,[103][104][105][106][108][109][110][111] assessed baseline NLR as a predictor for determining only severity, 32 articles 24,25,[29][30][31][32][33][34][38][39][40]43,45,48,77,[82][83][84][85][86][87][88][89][90][91][92]…”

Características y desenlaces de los pacientes ventilados por neumonía por SARS-CoV-2 en un hospital chileno

“…Aunque los pacientes con neumonía por SARS-CoV-2 asociada a SDRA presentan la mediana de la Cst mayor de 41 [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52] mL/cmH 2 O que en los pacientes con SDRA clásico con 32 [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] mL/cmH 2 O. La extensión del edema pulmonar en los pacientes con COVID-19 medidos por el peso pulmonar total con tomografía computarizada de tórax fue similar a los pacientes con SDRA clásico.…”

“…Otros grupos sudamericanos han reportado valores similares. 31 Los pacientes ventilados en PP constituyen cerca de la mitad de la población estudiada y se caracterizan por presentar puntajes de gravedad similares a los pacientes ventilados en PS; sin embargo, la mortalidad es elevada (32.1%). Esto se correlaciona con altas Pva, PaO 2 /FiO 2 más bajas en SU e IMC y peso mayor que los pacientes ventilados en supino (Tabla 2).…”