Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases

Pham, Hau Van; Hoang, Tuan N. A.; Duong, Hao T.; Phan, Lan Trong; Phan, Uyen Thi Ngoc; Ho, Nguyen X.; Hoang, Cuong

doi:10.1007/s13337-017-0402-8

Cited by 10 publications

(27 citation statements)

References 13 publications

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“…It has been reported that the mortality of severe HFMD was as high as 3.0% from 2008 to 2012 in China mainland [7]. Although the inactivated EV71 vaccine has been widely used to vaccinate infants and young children in several provinces of mainland China and has shown to be effective at protecting them from EV71-associated severe HFMD, the number of severe cases is still large, posing a threat to infants and young children in rural areas of Asia-Pacific region [4–6, 8].…”

Section: Introductionmentioning

confidence: 99%

Identification of immune and metabolic predictors of severe hand-foot-mouth disease

et al. 2019

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Hand, foot and mouth disease (HFMD) is an infectious disease that affects mostly children. The children with HFMD also have other immune and metabolic disorders. However, the association of these disorders with the severity of HFMD has not yet been determined. In this study, we used a case-control study design to examine the correlation of immune and metabolic disorders with HFMD development in children. 406 mild and severe patients were recruited and divided into different subgroups based on the number of days from the initial onset time to hospitalization (1, 2, 3, 4, and ≥5 days). Logistic regression model was used to define the predictors of severe HFMD. We found that the patients from rural area (OR = 1.76, 95% CI [1.19~2.63], P = 0.005) or with body temperature of >39°C (OR = 2.14, 95% CI [1.12~4.12], P = 0.022) exhibited higher risk for severe symptoms. In addition, the risk increased with the rise of body temperature by using a Chis-quare trend test ( P = 0.01). We also found that a decreased number of eosinophils was an predictor of severe HFMD at 1, 2, 3,and 4 days post infection (dpi). Decreased levels of Na + , Cl - , and creatine kinase were also predictors at 1 and ≥5 dpi. On the other hand, elevated level of globulin was a predictor for severe HFMD at 4 dpi and ≥5 dpi, and the increased number of neutrophils or increased level of alkaline phosphatase posed risk for severe HFMD at 3 and ≥5 dpi. Our results suggested that rural living, hyperpyrexia, changes in the immune system that include the numbers of eosinophils and neutrophils and the levels of IgG and globulin, and metabolic alterations, such as the levels of alkaline phosphatase, Na + , Cl - , and creatine kinase in peripheral blood are predictors of severe HFMD.

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Section: Introductionmentioning

confidence: 99%

Identification of immune and metabolic predictors of severe hand-foot-mouth disease

et al. 2019

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“…Так же как и в Хошимине, средний возраст пациентов составил 20 месяцев, 93,4% случаев пришлось на группу детей до 3 лет. Энтеровирус EV-А71 был выявлен у 63% «тяжелых» пациентов с положительным результатом тестирования на ЭВ [35]. Заболеваемость и смертельные случаи, связанные с HFMD, в 2011 г. регистрировались во всех частях Вьетнама, однако наибольшая доля как заболевших, так и умерших пришлась на южные провинции; в 2012 г. эпидемия распространилась на северную часть.…”

Section: заболеваемость энтеровирусной инфекцией в социалистической рunclassified

“…Наибольшее число тяжелых форм ЭВИ и летальных исходов во Вьетнаме было связано с вирусом EV-A71 [15,16,21,35]. В 2011 г. инфекция, обусловленная EV-A71, была лабораторно под-тверждена в 82% случаев ЭВИ, закончившихся летальным исходом [21].…”

Section: этиологические агенты энтеровирусной инфекции во вьетнамеunclassified

Enterovirus infection in the Socialist Republic of Vietnam

Голицына

Нгуен

Romanenkova

et al. 2019

Russian Journal of Infection and Immunity

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Human enterovirus infections comprise a group of infectious diseases caused by viruses of Enterovirus A-D species (genus Enterovirus, family Picornaviridae). Enterovirus infections can vary in clinical manifestations and severity, from asymptomatic infection to serious multisystem diseases. During evolution, enterovirus strains with increased neurovirulence or atypical pathogenicity may emerge exhibiting an epidemic potential. Recently, outbreaks of enterovirus infection with an increased rate of neurological manifestations, a significant percentage of severe cases and lethal outcomes have been observed worldwide, which were associated with enteroviruses EV-A71, EV-D68 etc. The World Health Organization has included EV-A71 and EV-D68 enterovirus infection together with some other dangerous viral diseases considered for inclusion in the List of Blueprint Priority Diseases. In connection with this, global enterovirus surveillance is important for controlling emergence and spread of epidemic enterovirus variants, prediction of establishing epidemic situation, timely conduction of preventive measures and vaccine development. A growing multi-field cooperation between Russia and Vietnam leads to increased two-way population migration, which actualizes scientific and practical collaboration in surveillance and control of infectious disease spread, including enterovirus infection. Currently, epidemiological surveillance of enterovirus infection in Vietnam is based on monitoring hand, foot and mouth disease (HFMD) rate, laboratory diagnostics of enterovirus infection and identification of enterovirus strains, mainly detected in severe patients. In 2001–2016, 34 non-polio virus types were identified in patients with enterovirus infection, largely represented by viruses EV-A71, CVA6, CVA10, and CVA16. Moreover, the peak incidence of enterovirus infection and related mortality rate were associated with the increased activity of EV-A71 virus. In Vietnam, EVA71 enterovirus of genotypes C1, C4, C5 and B5 circulated at different times. Over the last years, a new pandemic genotype virus CVA6 has been dominating as a causative agent of enterovirus infection in Vietnam as well as the majority of other countries. The data on phylogenetic relation between Vietnamese epidemic EV-A71 and CVA6 strains allowed to find that they underwent multiple betweencountry spreads, whereas their subsequent in-country dissemination resulted in 2011–2012 enterovirus outbreak and sustained high-level HFMD morbidity.

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“…Although this viral infection remains largely contagious 4, 5 , it is self-limiting and benign. Severe cases reportedly occurs in lower incidences (3.2% to 8.5%) and fatalities are rare 6– 8 . Starting in the West during the mid-1970’s 1, 2 HFMD emerged in the Asia-Pacific region in mid-1990s 9– 11 heralding as a major public health hazards 2, 10 .…”

Section: Introductionmentioning

confidence: 99%

“…With the complaints of mild-to-moderate fever (≥38.5°C 8 ; 101.3°F) childhood HFMD, characteristically manifest with body rashes 1, 4 , mostly of the knees and buttocks 4, 14 , augmented by painful oral/buccal ulcers and blisters. Papulo-vesicular rash in the extremities consequently forms pustules 6 .…”

Section: Introductionmentioning

confidence: 99%

Emerging Hand Foot Mouth Disease in Bangladeshi Children- First Report of Rapid Appraisal on Pocket Outbreak: Clinico-epidemiological Perspective Implicating Public Health Emergency

et al. 2019

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Background: Hand, foot and mouth disease (HFMD) is a common contagious disease among children under 5 years, particularly in the Asia-Pacific-region. We report a localized outbreak of childhood HFMD for the first time from Bangladesh, diagnosed only based on clinical features due to lack in laboratory-diagnostic facilities. Methods: Following the World Health Organization’s case-definition, we conducted a rapid-appraisal of HFMD among all of the 143 children attending Pabna Medical College and General Hospital with fever, mouth ulcers and extremity rash. Data were collected between September and November 2017 using a preset syndromic approach and stringent differential diagnostic-protocols. Results: The mean age of children was 2.9±2.3 years. There was a significant difference among the age and sex of children (P=0.98), first sibling being more belonging to middle-income families (62%). Younger children (<5 years) were more likely to suffer with moderate-to-high (38.5°C) fever (P<0.04), painful oral ulcers (P<0.03) and painful/itchy rash (P<0.01). Sex did not differ with other symptoms, but boys had less painful oral ulcers than girls (P<0.04). Fever (63%) and chicken-pox-like-rash (62%) was observed more in mid-October to mid-November than September to mid-October (P<0.01 and P<0.03, respectively). No differences in symptoms (fever, oral ulcers and extremity rash) were observed with precipitation, nor with ambient temperature. Children <5 years (85%) had quicker recovery (within 5 days) than those ≥5 years (69%), (P<0.04), with marginal differences in sex (P<0.05). Conclusions: Our findings highlight potential usefulness in diagnosing HFMD based on clinical parameters, although stringent differential diagnosis remains indispensable, which is particularly applicable for resource-constrained countries lacking appropriate virology/essential laboratories. Since no specific treatment or effective vaccination is available for HFMD, supportive therapy and preventive measures remain the primary methods to circumvent disease-transmission augmented by climate-related factors. Standardized virology laboratory warrants appropriate diagnosis and globally representative multivalent-vaccine deem essential towards preventing HFMD.

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Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases

Cited by 10 publications

References 13 publications

Identification of immune and metabolic predictors of severe hand-foot-mouth disease

Identification of immune and metabolic predictors of severe hand-foot-mouth disease

Enterovirus infection in the Socialist Republic of Vietnam

Emerging Hand Foot Mouth Disease in Bangladeshi Children- First Report of Rapid Appraisal on Pocket Outbreak: Clinico-epidemiological Perspective Implicating Public Health Emergency

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