Clinical Characteristics of Human Adenovirus Plastic Bronchitis in 10 Pediatric Cases: A Retrospective Study of Seven Years

Zeng, Lingsen; Wei, Jianhua; Tang, Yuyi; Liu, Enmei; Li, Qubei; Zang, Na

doi:10.1007/s12250-021-00394-8

Cited by 10 publications

(16 citation statements)

References 8 publications

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“…PB is a rare pulmonary condition that has been associated with asthma, atopy, sickle cell anemia, cystic fibrosis, and viral respiratory infections 1–4 . In rare cases, PB develops in children with no underlying disease 1 .…”

Section: Discussionmentioning

confidence: 99%

“…PB is a rare pulmonary condition that has been associated with asthma, atopy, sickle cell anemia, cystic fibrosis, and viral respiratory infections. [1][2][3][4] In rare cases, PB develops in children with no underlying disease. 1 Due to the heterogeneity of associated conditions understanding of pathophysiology remains challenging.…”

Section: Discussionmentioning

confidence: 99%

“…In a retrospective case series that included nine such children with a follow‐up period, seven children did not have recurrence 1 . Many cases of PB have occurred in influenza 2 or adenovirus 3 infections, but PB has been reported only twice in patients with human bocavirus (HBoV) 2,4 . Here, we present a severe case of PB secondary to HBoV in a previously healthy child with no asthma history, requiring extracorporeal membrane oxygenation (ECMO) and bronchoscopic cast removal.…”

mentioning

confidence: 97%

“…In a retrospective case series that included nine such children with a follow-up period, seven children did not have recurrence. 1 Many cases of PB have occurred in influenza 2 or adenovirus 3 infections, but PB has been reported only twice in patients with human bocavirus (HBoV).…”

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confidence: 99%

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Plastic bronchitis secondary to bocavirus in a previously healthy 4‐year‐old with negative lymphatic evaluation

Leon

Tsukahara²,

Boggs

et al. 2022

Pediatric Pulmonology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 2 more Smart Citations

Plastic bronchitis secondary to bocavirus in a previously healthy 4‐year‐old with negative lymphatic evaluation

Leon

Tsukahara²,

Boggs

et al. 2022

Pediatric Pulmonology

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show abstract

“…Rarely has PB occurred in patients with a chronic pulmonary disease such as asthma, cystic fibrosis, lymphangiomatosis, acute chest syndrome associated with sickle cell disease, and after heart transplantation [ 1 , 4 , 5 , 6 ]. Several infectious agents have been shown to be involved in PB development, including human bocavirus, H1N1 influenza virus, adenovirus, SARS-CoV-2 virus, Mycoplasma pneumoniae , and opportunistic fungi [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Antibiotics recommended for PB caused by infectious bacteria include macrolides, in particular, azithromycin, which has anti-inflammatory and immunomodulatory activity [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Plastic Bronchitis—A Serious Rare Complication Affecting Children Only after Fontan Procedure?

Pałyga-Bysiecka

Polewczyk

Kołodziej

et al. 2021

JCM

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Background: Plastic bronchitis (PB) may occur not only in children following palliative Fontan procedure but also in those without underlying heart disease. We aim to assess the clinical course, therapeutic measures, outcome, and follow-up of PB in children with congenital heart disease (CHD) and children without cardiac problems. Methods: This retrospective case series assessed children with PB admitted to hospital between 2015 and 2019. Parents or guardians of patients were contacted by e-mail or telephone between September 2017 and June 2019 to enquiry about recurrence of PB and strategy of treatment. The diagnosis of PB was based on the expectoration (spontaneous or during bronchoscopy) of endobronchial plugs. Results: This study delineated the clinical, histological, and laboratory features of plastic bronchitis in children following Fontan procedure (Group A) and in those without heart defects (Group B, non-CHD children). The main symptoms were cough accompanied by dyspnea, and hypoxemia with a decrease in oxygen saturation, often leading to acute respiratory failure. In children with CHD, the first episode of PB occurred at a relatively young age. Although chronic, i.e., lasting more than 3 weeks, inhaled therapy was implemented in both groups of patients, the recurrences of PB were observed. The mean time to PB recurrence after the first episode in Group A was longer than that in Group B (1.47 vs. 0.265 years, p = 0.2035). There was no re-episode with recurrence of PB in 3 cases out of 10 in total in Group A (30%) and 1 case out of 4 in total in Group B (25%). While the majority of children in Group A usually developed bronchial casts on the right side, the patients in Group B (without CHD) suffered from bronchial casts located only on the left side. Conclusions: Despite many similarities, clinical, histological, and laboratory studies in the children with plastic bronchitis after Fontan’s surgery and in children without heart defects suggest that there are differences in the course of the disease in patients without CHD, such as a more advanced age of the first episode of PB, the location of plastic casts on the left side, and a stronger role of inflammatory factors and mechanisms. Further research is needed to understand the pathophysiology of PB and choose the most appropriate therapy.

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Severe adenovirus infection: presentation of 3 cases

Galindo García,

Bolsa Ferrer,

Casajús Pelegay

et al. 2024

Anales de Pediatría (English Edition)

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Clinical Characteristics of Human Adenovirus Plastic Bronchitis in 10 Pediatric Cases: A Retrospective Study of Seven Years

Cited by 10 publications

References 8 publications

Plastic bronchitis secondary to bocavirus in a previously healthy 4‐year‐old with negative lymphatic evaluation

Plastic bronchitis secondary to bocavirus in a previously healthy 4‐year‐old with negative lymphatic evaluation

Plastic Bronchitis—A Serious Rare Complication Affecting Children Only after Fontan Procedure?

Severe adenovirus infection: presentation of 3 cases

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