Clinical characteristics of intraductal papillary mucinous neoplasm manifesting as acute pancreatitis or acute recurrent pancreatitis

Abstract

AP/ARP caused by IPMN was of infrequent occurrence. AP/ARP caused by IPMN occurred more frequently in the main-duct/combined type than in the branch-duct type. Most cases were mild in severity and benign in histopathology. AP/ARP can be an initial manifestation of IPMN, though uncommon, which leads to diagnosis.

Acute pancreatitis in intraductal papillary mucinous neoplasms: A common predictor of malignant intestinal subtype

“…Previous studies have found that AP is associated with main-duct and mixed-type IPMN. 2,6,7 In our study, we found that a history of AP is an independent predictor of histologic main duct involvement in resected IPMN, although this association is weak.…”

“…[1][2][3][4][5][6][7][8][9][10] Although several studies have described the clinical and pathologic characteristics of patients with IPMN presenting with AP, there is limited information as to what AP can tell us about the IPMN epithelial subtype and the likelihood of pancreatitis recurrence after resection. Furthermore, studies in which authors examined the association between AP and high-grade or invasive IPMN have often revealed conflicting results.…”

Parenchyma-Sparing Pancreatectomy for Presumed Noninvasive Intraductal Papillary Mucinous Neoplasms of the Pancreas

“…57,58 The value of PSP to efficiently treat pancreatic symptoms should be highlighted because (i) symptoms per se are not associated with an increased risk of malignancy, particularly in branch-duct disease, 4,38,46 and (ii) acute pancreatitis due to IPMNs is of mild or moderate severity in almost all cases, 59 thus not justifying a standard surgical resection exposing patients to symptoms of surgically induced pancreatic insufficiency.…”

Intraductal Papillary Mucinous Neoplasm of the Pancreas: Current Perspectives

“…These include tumor size, lymph node involvement, tumor grade, percentage of the invasive junction, and vascular and perineural involvement. [46][47][48][49][50][51] It is reported that multifocal IPMNs are more frequently located in the caudal part of the pancreas with higher serum tumor marker (CA 19-9/CEA) levels, and higher risk of malignancy. 52 The risk of malignant transformation is reported to be 58.8% for multifocal IPMN and 49.2% for unilocal IPMN.…”